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Sökning: onr:"swepub:oai:DiVA.org:uu-203545" > Serum Folate and B1...

Serum Folate and B12 Levels in Association With Cognitive Impairment Among Seniors : Results From the VELESTINO Study in Greece and Meta-Analysis

Michelakos, Theodoros (författare)
Kousoulis, Antonis A. (författare)
Katsiardanis, Konstantinos (författare)
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Dessypris, Nick (författare)
Anastasiou, Anastasia (författare)
Katsiardani, Kalliopi-Penelopi (författare)
Kanavidis, Prodromos (författare)
Stefanadis, Christodoulos (författare)
Papadopoulos, Fotios C., (författare)
Uppsala universitet, Psykiatri, Akademiska sjukhuset
Petridou, Eleni Th (författare)
visa färre...
2013
Engelska.
Ingår i: Journal of Aging and Health. - 0898-2643 .- 1552-6887. ; 25:4, s. 589-616
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • <p>Objective: To summarize existing evidence on the effect of serum folate and vitamin B12 levels on cognitive impairment among elders via a meta-analysis, also including unpublished data from a cross-sectional study of seniors ( &gt; 65 years) residing in Velestino, Greece. Method: Serum measurements and Mini-Mental State Examination (MMSE) assessments were available for 593 Velestinians. In addition, 12 studies availing data on folate blood levels (N = 9,747) and 9 on B12 (N = 8,122) were identified following a search algorithm; pooled effect estimates were derived. Results: Cognitive impairment (MMSE &lt; 24) among Velestenians was associated with lower education level in both genders; decreased social activity, depressive symptoms and low folate levels in males; older age in females. Meta-analyses showed an adverse effect of low-folate levels on cognition (OR: 1.66, 95% CI: 1.40-1.96); B12 was nonsignificantly associated (OR: 1.11, 95% CI: 0.88-1.40). Discussion: Low folate levels are associated with cognitive impairment of seniors; underlying pathophysiological mechanisms should be further explored.</p>

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  (hsv//swe)
MEDICAL AND HEALTH SCIENCES  (hsv//eng)

Nyckelord

folate
B12
cognitive impairment
meta-analysis
aged

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