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LIBRIS Formathandbok  (Information om MARC21)
00004473naa a2200541 4500
008150420s2015 | |||||||||||000 ||eng|
024a urn:nbn:se:uu:diva-2515152 urn
024a https://doi.org/10.2478/raon-2014-00152 DOI
024a http://kipublications.ki.se/Default.aspx?queryparsed=id:1308803832 URI
040 a (SwePub)uud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
100a Carlsson, Jörgenu Uppsala universitet,Medicinsk strålningsvetenskap4 aut0 (Swepub:uu)jorgcarl
2451 0a EGFR-expression in primary urinary bladder cancer and corresponding metastases and the relation to HER2-expression. On the possibility to target these receptors with radionuclides
264 1c 2015
338 a print2 rdacarrier
506 a gratis
520 a Background. There is limited effect of tyrosine kinase inhibitors or "naked" antibodies binding EGFR or HER2 for therapy of metastasized urinary bladder canter and these methods are therefore not routinely used. Targeting radionuclides to the extracellular domain of the receptors is potentially a better possibility. Methods. EGFR- and HER2-expression was analyzed for primary tumors and corresponding metastases from 72 patients using immunohistochemistry and the internationally recommended HercepTest. Intracellular mutations were not analyzed since only the receptors were considered as targets and intracellular abnormalities should have minor effect on radiation dose. Results. EGFR was positive in 71% of the primary tumors and 69% of corresponding metastases. Local and distant metastases were EGFR-positive in 75% and 66% of the cases, respectively. The expression frequency of HER2 in related lesions was slightly higher (data from previous study). The EGFR-positive tumors expressed EGFR in metastases in 86% of the cases. The co-expression of EGFR and HER2 was 57% for tumors and 53% for metastases. Only 3% and 10% of the lesions were negative for both receptors in tumors and metastases, respectively. Thus, targeting these receptors with radionuclides might be applied for most patients. Conclusions. At least one of the EGFR- or HER2-receptors was present in most cases and co-expressed in more than half the cases. It is therefore interesting to deliver radionuclides for whole-body receptor-analysis, dosimetry and therapy. This can hopefully compensate for resistance to other therapies and more patients can hopefully be treated with curative instead of palliative intention.
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Radiology, Nuclear Medicine and Medical Imaging0 (SwePub)302082 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Radiologi och bildbehandling0 (SwePub)302082 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicin0 (SwePub)3022 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicine0 (SwePub)3022 hsv//eng
653 a EGFR
653 a HER2
653 a radionuclides
653 a resistance
653 a urinary bladder cancer metastases
700a Wester, Kennethu Uppsala universitet,Institutionen för immunologi, genetik och patologi4 aut0 (Swepub:uu)kennwest
700a De La Torre, Manuelu Uppsala universitet,Molekylär och morfologisk patologi4 aut0 (Swepub:uu)manutorr
700a Malmström, Per-Unou Uppsala universitet,Urologkirurgi4 aut0 (Swepub:uu)perunoms
700a Gardmark, Truls4 aut
700a Malmstrom, PU4 aut
700a De La Torre, M4 aut
700a Wester, K4 aut
700a Carlsson, J4 aut
700a Gardmark, Tu Karolinska Institutet4 aut0 (Swepub:ki)d7f28d2561f6f221cba6f4db9b7336ce
710a Uppsala universitetb Medicinsk strålningsvetenskap4 org
773t Radiology and Oncologyg 49:1, s. 50-58q 49:1<50-58x 1318-2099x 1581-3207
8564 8u http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-251515x lärosäteslänky Till lärosätets (uu) databas
8564 8u https://doi.org/10.2478/raon-2014-0015
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:130880383

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