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Sökning: onr:"swepub:oai:DiVA.org:uu-264676" > Epigenome-wide asso...

Epigenome-wide association study (EWAS) of BMI, BMI change and waist circumference in African American adults identifies multiple replicated loci

Demerath, Ellen W., (författare)
Univ Minnesota, Sch Publ Hlth, Div Epidemiol & Community Hlth, Minneapolis, MN 55454 USA.
Guan, Weihua, (författare)
Univ Minnesota, Sch Publ Hlth, Div Biostat, Minneapolis, MN 55454 USA.
Grove, Megan L., (författare)
Univ Texas Hlth Sci Ctr Houston, Sch Publ Hlth, Ctr Human Genet, Houston, TX 77030 USA.
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Aslibekyan, Stella, (författare)
Univ Alabama Birmingham, Sch Publ Hlth, Dept Epidemiol, Birmingham, AL 35294 USA.
Mendelson, Michael, (författare)
NHLBI, Populat Sci Branch, NIH, Bethesda, MD 20824 USA.;Framingham Heart Dis Epidemiol Study, Framingham, MA 01702 USA.;Boston Childrens Hosp, Dept Cardiol, Boston, MA 02215 USA.
Zhou, Yi-Hui, (författare)
N Carolina State Univ, Dept Stat, Raleigh, NC 27695 USA.
Hedman, Åsa K., (författare)
Uppsala universitet, Molekylär epidemiologi, Uppsala universitet, Science for Life Laboratory, SciLifeLab, Univ Oxford, Wellcome Trust Ctr Human Genet, Oxford, England.
Sandling, Johanna K., (författare)
Uppsala universitet, Molekylär epidemiologi, Uppsala universitet, Science for Life Laboratory, SciLifeLab, Wellcome Trust Sanger Inst, Hinxton, England.
Li, Li-An (författare)
Irvin, Marguerite R. (författare)
Zhi, Degui, (författare)
Univ Alabama Birmingham, Sch Publ Hlth, Dept Biostat, Birmingham, AL 35294 USA.
Deloukas, Panos, (författare)
Wellcome Trust Sanger Inst, Hinxton, England.;Queen Mary Univ London, Barts & London Sch Med & Dent, William Harvey Res Inst, London, England.;King Abdulaziz Univ, Princess Al Jawhara Al Brahim Ctr Excellence Res, Jeddah 21589, Saudi Arabia.
Liang, Liming, (författare)
NHLBI, Populat Sci Branch, NIH, Bethesda, MD 20824 USA.;Framingham Heart Dis Epidemiol Study, Framingham, MA 01702 USA.;Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA.;Harvard Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02115 USA.
Liu, Chunyu, (författare)
Framingham Heart Dis Epidemiol Study, Framingham, MA 01702 USA.;Boston Univ, Dept Biostat, Boston, MA 02118 USA.
Bressler, Jan, (författare)
Univ Texas Hlth Sci Ctr Houston, Sch Publ Hlth, Ctr Human Genet, Houston, TX 77030 USA.
Spector, Tim D., (författare)
Kings Coll London, Dept Twin Res & Genet Epidemiol, London SE1 7EH, England.
North, Kari, (författare)
Univ N Carolina, Dept Epidemiol, Chapel Hill, NC 27514 USA.
Li, Yun, (författare)
Univ N Carolina, Dept Genet, Chapel Hill, NC 27599 USA.;Univ N Carolina, Dept Biostat, Chapel Hill, NC 27599 USA.;Univ N Carolina, Dept Comp Sci, Chapel Hill, NC 27599 USA.
Absher, Devin M., (författare)
Hudson Alpha Inst Biotechnol, Huntsville, AL 35806 USA.
Levy, Daniel (författare)
Arnett, Donna K., (författare)
Univ Alabama Birmingham, Sch Publ Hlth, Dept Epidemiol, Birmingham, AL 35294 USA.
Fornage, Myriam, (författare)
Univ Texas Hlth Sci Ctr Houston, Sch Publ Hlth, Ctr Human Genet, Houston, TX 77030 USA.;Baylor Coll Med, Human Genome Sequencing Ctr, Houston, TX 77030 USA.
Pankow, James S., (författare)
Univ Minnesota, Sch Publ Hlth, Div Epidemiol & Community Hlth, Minneapolis, MN 55454 USA.
Boerwinkle, Eric, (författare)
Univ Texas Hlth Sci Ctr Houston, Sch Publ Hlth, Ctr Human Genet, Houston, TX 77030 USA.;Baylor Coll Med, Human Genome Sequencing Ctr, Houston, TX 77030 USA.
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Uppsala universitet Medicinska och farmaceutiska vetenskapsområdet. Medicinska fakulteten. Institutionen för medicinska vetenskaper. Molekylär epidemiologi. (creator_code:org_t)
Uppsala universitet Science for Life Laboratory, SciLifeLab. (creator_code:org_t)
2015
Engelska.
Ingår i: Human Molecular Genetics. - 0964-6906 .- 1460-2083. ; 24:15, s. 4464-4479
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • Obesity is an important component of the pathophysiology of chronic diseases. Identifying epigenetic modifications associated with elevated adiposity, including DNA methylation variation, may point to genomic pathways that are dysregulated in numerous conditions. The Illumina 450K Bead Chip array was used to assay DNA methylation in leukocyte DNA obtained from 2097 African American adults in the Atherosclerosis Risk in Communities (ARIC) study. Mixed-effects regression models were used to test the association of methylation beta value with concurrent body mass index (BMI) and waist circumference (WC), and BMI change, adjusting for batch effects and potential confounders. Replication using whole-blood DNA from 2377 White adults in the Framingham Heart Study and CD4+ T cell DNA from 991 Whites in the Genetics of Lipid Lowering Drugs and Diet Network Study was followed by testing using adipose tissue DNA from 648 women in the Multiple Tissue Human Expression Resource cohort. Seventy-six BMI-related probes, 164 WC-related probes and 8 BMI change-related probes passed the threshold for significance in ARIC (P < 1 x 10(-7); Bonferroni), including probes in the recently reported HIF3A, CPT1A and ABCG1 regions. Replication using blood DNA was achieved for 37 BMI probes and 1 additional WC probe. Sixteen of these also replicated in adipose tissue, including 15 novel methylation findings near genes involved in lipid metabolism, immune response/cytokine signaling and other diverse pathways, including LGALS3BP, KDM2B, PBX1 and BBS2, among others. Adiposity traits are associated with DNA methylation at numerous CpG sites that replicate across studies despite variation in tissue type, ethnicity and analytic approaches.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska grundvetenskaper -- Medicinsk genetik (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Medical Genetics (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Medicinsk bioteknologi -- Medicinsk bioteknologi (med inriktning mot cellbiologi (inklusive stamcellsbiologi), molekylärbiologi, mikrobiologi, biokemi eller biofarmaci) (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Medical Biotechnology -- Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy) (hsv//eng)

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