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Sökning: onr:"swepub:oai:DiVA.org:uu-273745" > Pleiotropic Analysi...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004043naa a2200793 4500
001oai:DiVA.org:uu-273745
003SwePub
008160118s2015 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:132494862
024a urn:nbn:se:uu:diva-2737452 urn
024a https://doi.org/10.1158/1055-9965.EPI-15-05962 DOI
024a http://kipublications.ki.se/Default.aspx?queryparsed=id:1324948622 URI
040 a (SwePub)uud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
100a Lee, Eunjung4 aut
2451 0a Pleiotropic Analysis of Cancer Risk Loci on Esophageal Adenocarcinoma Risk.
264 1c 2015
338 a print2 rdacarrier
506 a gratis
520 a BACKGROUND: Several cancer-associated loci identified from genome-wide association studies (GWAS) have been associated with risks of multiple cancer sites, suggesting pleiotropic effects. We investigated whether GWAS-identified risk variants for other common cancers are associated with risk of esophageal adenocarcinoma (EA) or its precursor, Barrett's esophagus.METHODS: We examined the associations between risks of EA and Barrett's esophagus and 387 SNPs that have been associated with risks of other cancers, by using genotype imputation data on 2,163 control participants and 3,885 (1,501 EA and 2,384 Barrett's esophagus) case patients from the Barrett's and Esophageal Adenocarcinoma Genetic Susceptibility Study, and investigated effect modification by smoking history, body mass index (BMI), and reflux/heartburn.RESULTS: After correcting for multiple testing, none of the tested 387 SNPs were statistically significantly associated with risk of EA or Barrett's esophagus. No evidence of effect modification by smoking, BMI, or reflux/heartburn was observed.CONCLUSIONS: Genetic risk variants for common cancers identified from GWAS appear not to be associated with risks of EA or Barrett's esophagus.IMPACT: To our knowledge, this is the first investigation of pleiotropic genetic associations with risks of EA and Barrett's esophagus. Cancer Epidemiol Biomarkers Prev; 24(11); 1801-3. ©2015 AACR.
700a Stram, Daniel O4 aut
700a Ek, Weronica E4 aut
700a Onstad, Lynn E4 aut
700a MacGregor, Stuart4 aut
700a Gharahkhani, Puya4 aut
700a Ye, Weimin4 aut
700a Lagergren, Jesper4 aut
700a Shaheen, Nicholas J4 aut
700a Murray, Liam J4 aut
700a Hardie, Laura J4 aut
700a Gammon, Marilie D4 aut
700a Chow, Wong-Ho4 aut
700a Risch, Harvey A4 aut
700a Corley, Douglas A4 aut
700a Levine, David M4 aut
700a Whiteman, David C4 aut
700a Bernstein, Leslie4 aut
700a Bird, Nigel C4 aut
700a Vaughan, Thomas L4 aut
700a Wu, Anna H4 aut
700a MacGregor, S4 aut
700a Gammon, MD4 aut
700a Levine, DM4 aut
700a Hardie, LJ4 aut
700a Lagergren, Ju Karolinska Institutet4 aut
700a Bird, NC4 aut
700a Ye, WMu Karolinska Institutet4 aut
700a Gharahkhani, P4 aut
700a Vaughan, TL4 aut
700a Chow, WH4 aut
700a Lee, E4 aut
700a Stram, DO4 aut
700a Onstad, LE4 aut
700a Shaheen, NJ4 aut
700a Murray, LJ4 aut
700a Wu, AH4 aut
700a Bernstein, L4 aut
700a Risch, HA4 aut
700a Whiteman, DC4 aut
700a Ek, WE4 aut
700a Corley, DA4 aut
710a Karolinska Institutet4 org
773t Cancer Epidemiology, Biomarkers and Preventiong 24:11q 24:11x 1055-9965x 1538-7755
8564 8u http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-273745x lärosäteslänky Till lärosätets (uu) databas
8564 8u https://doi.org/10.1158/1055-9965.EPI-15-0596
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:132494862

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