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Sökning: onr:"swepub:oai:DiVA.org:uu-279109" > Comorbidity of Cogn...

Comorbidity of Cognitive Impairment and Late-Life Depression Increase Mortality : Results From a Cohort of Community-Dwelling Elderly Individuals in Rural Greece

Georgakis, Marios K (författare)
Papadopoulos, Fotios C, (författare)
Uppsala universitet, Psykiatri, Akademiska sjukhuset
Protogerou, Athanasios D (författare)
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Pagonari, Ioanna (författare)
Sarigianni, Fani (författare)
Biniaris-Georgallis, Stylianos-Iason (författare)
Kalogirou, Eleni I (författare)
Thomopoulos, Thomas P (författare)
Kapaki, Elisabeth (författare)
Papageorgiou, Charalampos (författare)
Papageorgiou, Socratis G (författare)
Tousoulis, Dimitrios (författare)
Petridou, Eleni Th (författare)
visa färre...
2016
Engelska.
Ingår i: Journal of Geriatric Psychiatry and Neurology. - 0891-9887 .- 1552-5708. ; 29:4, s. 195-204
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • <p><strong>OBJECTIVE:</strong> To investigate the association of cognitive impairment (COGI) and depression with all-cause mortality and cardiovascular-specific mortality among community-dwelling elderly individuals in rural Greece.</p><p><strong>METHODS:</strong> Cognition and depressive symptomatology of 676 Velestino town residents aged ≥60 years were assessed using Mini-Mental State Examination (MMSE) and Geriatric Depression Scale (GDS), respectively. Eight-year all-cause mortality and cardiovascular mortality were explored by multivariate Cox regression models controlling for major confounders.</p><p><strong>RESULTS:</strong> Two hundred and one patients died during follow-up. Cognitive impairment (MMSE ≤ 23) was independently associated with all-cause mortality (hazard ratio [HR]: 1.57, 95% confidence interval [CI]: 1.13-2.18) and cardiovascular mortality (HR: 1.57, 95%CI: 1.03-2.41). Moderate to severe depression (GDS &gt; 10) was significantly associated only with a 51% increase in all-cause mortality. A male-specific association was noted for moderate to severe depression, whereas the effect of COGI was limited to females. Noteworthy, COGI and depression comorbidity, rather than their sole presence, increased all-cause mortality and cardiovascular mortality by 66% and 72%, respectively. The mortality effect of COGI was augmented among patients with depression and of depression among patients with COGI.</p><p><strong>CONCLUSION:</strong> COGI and depression, 2 entities often coexisting among elderly individuals, appear to increase all-cause mortality and cardiovascular mortality. Gender-specific modes may prevail but their comorbidity should be carefully assessed, as it seems to represent an independent index of increased frailty, which eventually shortens life expectancy.</p>

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Psykiatri (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Psychiatry (hsv//eng)

Nyckelord

cognitive impairment; dementia; depression; elderly; survival; mortality

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