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Folate and B12 serum levels in association with depression in the aged : a systematic review and meta-analysis

Petridou, Eleni Th. (författare)
Univ Athens, Sch Med, Dept Hyg Epidemiol & Med Stat, Athens, Greece
Kousoulis, Antonis A. (författare)
Univ Athens, Sch Med, Dept Hyg Epidemiol & Med Stat, Athens, Greece
Michelakos, Theodoros (författare)
Univ Athens, Sch Med, Dept Hyg Epidemiol & Med Stat, Athens, Greece
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Papathoma, Paraskevi (författare)
Univ Athens, Sch Med, Dept Hyg Epidemiol & Med Stat, Athens, Greece
Dessypris, Nick (författare)
Univ Athens, Sch Med, Dept Hyg Epidemiol & Med Stat, Athens, Greece
Papadopoulos, Fotios C. (författare)
Uppsala universitet,Psykiatri, Akademiska sjukhuset
Stefanadis, Christodoulos (författare)
Univ Athens, Sch Med, Hippokrat Hosp, Dept Cardiol 1, Athens, Greece
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 (creator_code:org_t)
2016
2016
Engelska.
Ingår i: Aging & Mental Health. - 1360-7863 .- 1364-6915. ; 20:9, s. 965-973
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • OBJECTIVES: To systematically review and meta-analyse existing evidence on the association between folate/B12, and depression among the aged people.METHODS: Following PRISMA/STROBE guidelines, the Medline abstracts were retrieved using an algorithm comprising relevant MeSH terms. Publications on the association of folate/B12 serum measurements with depression were abstracted independently by two reviewers and included in both gender and gender-specific meta-analyses, following recarculations of published data as appropriate. The Newcastle-Ottawa scale was used to evaluate the quality of included studies.RESULTS: Both gender data were contributed by 11 folate-related (7949 individuals) and 9 B12-related studies (6308 individuals), whereas gender-specific data by 4 folate-related (3409 individuals) and 3 B12-related studies (1934 individuals). A statistically significant overall association between both exposures of interest (low folate and B12 levels) and depression was observed (ORfolate:1.23, 95%CI:1.07-1.43, ORB12:1.20, 95%CI:1.02-1.42). Gender-specific estimates pointed to a statistically significant positive association between low B12 levels and depression only among women (OR:1.33, 95%CI:1.02-1.74); the gender specific associations of low folate levels with depression were, however, non-significant and of counter-direction (ORfemales:1.37, 95%CI:0.90-2.07; ORmales:0.84, 95%CI:0.57-1.25).CONCLUSION: Low folate and B12 serum levels seem to be associated with depression in the aged. The gender-specific analyses are confined to a positive association of low B12 with depression among older women and call for further research in this direction.

Ämnesord

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Psychiatry (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Psykiatri (hsv//swe)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine (hsv//eng)

Nyckelord

folate; vitamin B12; depression; meta-analysis; gender; geriatric

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