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A Meta-analysis of Individual Participant Data Reveals an Association between Circulating Levels of IGF-I and Prostate Cancer Risk

Travis, Ruth C., (författare)
Univ Oxford, Nuffield Dept Populat Hlth, Canc Epidemiol Unit, Oxford, England.
Appleby, Paul N., (författare)
Univ Oxford, Nuffield Dept Populat Hlth, Canc Epidemiol Unit, Oxford, England.
Martin, Richard M., (författare)
Univ Bristol, Sch Social & Community Med, Bristol, Avon, England.;Univ Bristol, MRC, Univ Bristol Integrat Epidemiol Unit, Bristol, Avon, England.;Natl Inst Hlth Res Bristol, Biomed Res Unit Nutr, Bristol, Avon, England.
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Holly, Jeff M. P., (författare)
Univ Bristol, Fac Med, Sch Clin Sci, Bristol, Avon, England.
Albanes, Demetrius, (författare)
NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA.
Black, Amanda, (författare)
NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA.
Bueno-de-Mesquita, H. Bas, (författare)
Natl Inst Publ Hlth & Environm RIVM, Dept Determinants Chron Dis, Bilthoven, Netherlands.;Univ Med Ctr, Dept Gastroenterol & Hepatol, Utrecht, Netherlands.;Univ Malaya, Fac Med, Dept Social & Prevent Med, Kuala Lumpur, Malaysia.;Univ London Imperial Coll Sci Technol & Med, Sch Publ Hlth, Dept Epidemiol & Biostat, London, England.
Chan, June M., (författare)
Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA 94143 USA.;Univ Calif San Francisco, Dept Urol, San Francisco, CA USA.
Chen, Chu, (författare)
Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA.
Chirlaque, Maria-Dolores, (författare)
IMIB Arrixaca, Murcia Reg Hlth Council, Dept Epidemiol, Murcia, Spain.;CIBER Epidemiol & Salud Publ, Madrid, Spain.
Cook, Michael B., (författare)
NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA.
Deschasaux, Melanie, (författare)
Univ Paris 07, Univ Paris 05, Univ Paris 13,Inserm,U1153,INRA,U1125,Cnam, Sorbonne Paris Cite,Epidemiol & Biostat Res Ctr,N, F-93017 Bobigny, France.
Donovan, Jenny L., (författare)
Univ Bristol, Sch Social & Community Med, Bristol, Avon, England.
Ferrucci, Luigi, (författare)
NIA, Intramural Res Program, Baltimore, MD 21224 USA.
Galan, Pilar, (författare)
Univ Paris 07, Univ Paris 05, Univ Paris 13,Inserm,U1153,INRA,U1125,Cnam, Sorbonne Paris Cite,Epidemiol & Biostat Res Ctr,N, F-93017 Bobigny, France.
Giles, Graham G., (författare)
Canc Council Victoria, Canc Epidemiol Ctr, Melbourne, Vic, Australia.;Univ Melbourne, Melbourne Sch Populat & Global Hlth, Ctr Biostat & Epidemiol, Melbourne, Vic, Australia.
Giovannucci, Edward L., (författare)
Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA.;Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA.;Harvard Univ, Sch Publ Hlth, Dept Med, 665 Huntington Ave, Boston, MA 02115 USA.
Gunter, Marc J., (författare)
Univ London Imperial Coll Sci Technol & Med, Sch Publ Hlth, Dept Epidemiol & Biostat, London, England.
Habel, Laurel A., (författare)
Kaiser Permanente No Calif, Div Res, Oakland, CA USA.
Hamdy, Freddie C., (författare)
Univ Oxford, Nuffield Dept Surg, Oxford, England.
Helzlsouer, Kathy J., (författare)
St Johns Mercy Med Ctr, Prevent & Res Ctr, Baltimore, MD USA.
Hercberg, Serge, (författare)
Univ Paris 07, Univ Paris 05, Univ Paris 13,Inserm,U1153,INRA,U1125,Cnam, Sorbonne Paris Cite,Epidemiol & Biostat Res Ctr,N, F-93017 Bobigny, France.
Hoover, Robert N., (författare)
NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA.
Janssen, Joseph A. M. J. L., (författare)
Erasmus MC, Dept Internal Med, Rotterdam, Netherlands.
Kaaks, Rudolf, (författare)
German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Germany.
Kubo, Tatsuhiko, (författare)
Univ Occupat & Environm Hlth, Kitakyushu, Fukuoka 807, Japan.
Le Marchand, Loic, (författare)
Univ Hawaii, Ctr Canc, Honolulu, HI 96822 USA.
Metter, E. Jeffrey, (författare)
NIA, Intramural Res Program, Baltimore, MD 21224 USA.;Univ Tennessee, Ctr Hlth Sci, Dept Neurol, Memphis, TN 38163 USA.
Mikami, Kazuya, (författare)
Kyoto Prefectural Univ Med, Kyoto, Japan.
Morris, Joan K., (författare)
Queen Mary Univ London, Wolfson Inst Prevent Med, Charterhouse Sq, London, England.
Neal, David E., (författare)
Univ Cambridge, Dept Oncol, Cambridge, England.
Neuhouser, Marian L., (författare)
Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA.
Ozasa, Kotaro, (författare)
Radiat Effects Res Fdn, Hiroshima, Japan.
Palli, Domenico, (författare)
Canc Res & Prevent Inst ISPO, Mol & Nutr Epidemiol Unit, Florence, Italy.
Platz, Elizabeth A., (författare)
Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA.
Pollak, Michael N., (författare)
McGill Univ, Dept Med, Montreal, PQ, Canada.;McGill Univ, Dept Oncol, Montreal, PQ, Canada.
Price, Alison J., (författare)
Univ Oxford, Nuffield Dept Populat Hlth, Canc Epidemiol Unit, Oxford, England.
Roobol, Monique J., (författare)
Erasmus MC, Dept Urol, Rotterdam, Netherlands.
Schaefer, Catherine, (författare)
Kaiser Permanente No Calif, Div Res, Oakland, CA USA.
Schenk, Jeannette M., (författare)
Fred Hutchinson Canc Res Ctr, Canc Prevent Program, 1124 Columbia St, Seattle, WA 98104 USA.;Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA.
Severi, Gianluca, (författare)
Canc Council Victoria, Canc Epidemiol Ctr, Melbourne, Vic, Australia.;Univ Melbourne, Melbourne Sch Populat & Global Hlth, Ctr Biostat & Epidemiol, Melbourne, Vic, Australia.;Human Genet Fdn, Turin, Italy.
Stampfer, Meir J., (författare)
Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA.;Harvard Univ, Brigham & Womens Hosp, Sch Med, Channing Div Network Med, Boston, MA 02115 USA.
Stattin, Pär, (författare)
Uppsala universitet, Urologkirurgi, Umea Univ, Dept Surg & Perioperat Sci Urol & Androl, Umea, Sweden.
Tamakoshi, Akiko, (författare)
Hokkaido Univ, Grad Sch Med, Sapporo, Hokkaido, Japan.
Tangen, Catherine M., (författare)
Univ Washington, Fred Hutchinson Canc Res Ctr, SWOG Stat Ctr, Seattle, WA 98195 USA.;Univ Washington, Dept Biostat, Seattle, WA 98195 USA.
Touvier, Mathilde, (författare)
Univ Paris 07, Univ Paris 05, Univ Paris 13,Inserm,U1153,INRA,U1125,Cnam, Sorbonne Paris Cite,Epidemiol & Biostat Res Ctr,N, F-93017 Bobigny, France.
Wald, Nicholas J., (författare)
Queen Mary Univ London, Wolfson Inst Prevent Med, Charterhouse Sq, London, England.
Weiss, Noel S., (författare)
Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA.
Ziegler, Regina G., (författare)
NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA.
Key, Timothy J., (författare)
Univ Oxford, Nuffield Dept Populat Hlth, Canc Epidemiol Unit, Oxford, England.
Allen, Naomi E., (författare)
Univ Oxford, Nuffield Dept Populat Hlth, Clin Trial Serv Unit, Oxford, England.;Univ Oxford, Nuffield Dept Populat Hlth, Epidemiol Studies Unit, Oxford, England.
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2016
Engelska.
Ingår i: Cancer Research. - 0008-5472 .- 1538-7445. ; 76:8, s. 2288-2300
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • <p>The role of insulin-like growth factors (IGF) in prostate cancer development is not fully understood. To investigate the association between circulating concentrations of IGFs (IGF-I, IGF-II, IGFBP-1, IGFBP-2, and IGFBP-3) and prostate cancer risk, we pooled individual participant data from 17 prospective and two cross-sectional studies, including up to 10,554 prostate cancer cases and 13,618 control participants. Conditional logistic regression was used to estimate the ORs for prostate cancer based on the study-specific fifth of each analyte. Overall, IGF-I, IGF-II, IGFBP-2, and IGFBP-3 concentrations were positively associated with prostate cancer risk (P-trend all &lt;= 0.005), and IGFBP-1 was inversely associated weakly with risk (P-trend = 0.05). However, heterogeneity between the prospective and cross-sectional studies was evident (P-heterogeneity = 0.03), unless the analyses were restricted to prospective studies (with the exception of IGF-II, P-heterogeneity = 0.02). For prospective studies, the OR for men in the highest versus the lowest fifth of each analyte was 1.29 (95% confidence interval, 1.16-1.43) for IGF-I, 0.81 (0.68-0.96) for IGFBP-1, and 1.25 (1.12-1.40) for IGFBP-3. These associations did not differ significantly by time-to-diagnosis or tumor stage or grade. After mutual adjustment for each of the other analytes, only IGF-I remained associated with risk. Our collaborative study represents the largest pooled analysis of the relationship between prostate cancer risk and circulating concentrations of IGF-I, providing strong evidence that IGF-I is highly likely to be involved in prostate cancer development.</p>

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

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