Mem Sloan Kettering Canc Ctr, Dept Med, 1275 York Ave, New York, NY 10021 USA.
Yeager, Meredith (författare)
NCI, Div Canc Epidemiol & Genet, Canc Genom Res Lab, Gaithersburg, MD USA.
Wang, Zhaoming (författare)
NCI, Div Canc Epidemiol & Genet, Canc Genom Res Lab, Gaithersburg, MD USA.
Ghesquieres, Herve (författare)
Ctr Leon Berard, Canc Res Ctr Lyon, Dept Hematol, F-69373 Lyon, France.;CNRS, UMR5239, Lab Biol Mol Cellule, Pierre Benite, France.
Mckay, James (författare)
Int Agcy Res Canc, 150 Cours Albert Thomas, F-69372 Lyon, France.
Conde, Lucia (författare)
Univ Alabama Birmingham, Sch Publ Hlth, Dept Epidemiol, Birmingham, AL 35294 USA.;Univ Alabama Birmingham, Ctr Comprehens Canc, Birmingham, AL 35294 USA.;Univ Calif Berkeley, Sch Publ Hlth, Div Environm Hlth Sci, Berkeley, CA 94720 USA.
de Bakker, Paul I. W. (författare)
Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands.;Univ Med Ctr Utrecht, Dept Med Genet & Epidemiol, Utrecht, Netherlands.
Cox, David G. (författare)
Ctr Leon Berard, Canc Res Ctr Lyon, INSERM U1052, F-69373 Lyon, France.
Burdett, Laurie (författare)
NCI, Div Canc Epidemiol & Genet, Canc Genom Res Lab, Gaithersburg, MD USA.
Monnereau, Alain (författare)
Sorbonne Paris Cite, INSERM, Ctr Res Epidemiol & Stat, Epidemiol Childhood & Adolescent Canc Grp, Paris, France.;Univ Paris 05, Paris, France.;Inst Bergonie, Registre Hemopathies Malignes Gironde, Bordeaux, France.
Flowers, Christopher R. (författare)
Emory Univ, Sch Med, Winship Canc Inst, Atlanta, GA USA.
De Roos, Anneclaire J. (författare)
Drexel Univ, Sch Publ Hlth, Dept Environm & Occupat Hlth, Philadelphia, PA 19104 USA.;Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA.
Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA.;Brigham & Womens Hosp, Dept Med, Channing Div Network Med, 75 Francis St, Boston, MA USA.;Harvard Univ, Sch Med, Boston, MA USA.
Zeleniuch-Jacquotte, Anne (författare)
NYU, Sch Med, Dept Populat Hlth, New York, NY USA.;NYU, Sch Med, Dept Environm Med, New York, NY USA.;NYU, Langone Med Ctr, Perlmutter Canc Ctr, New York, NY USA.
Lawrence, Charles (författare)
WESTAT Corp, Rockville, MD 20850 USA.
Hutchinson, Amy (författare)
NCI, Div Canc Epidemiol & Genet, Canc Genom Res Lab, Gaithersburg, MD USA.
Zhi, Degui (författare)
Univ Alabama Birmingham, Dept Biostat, Birmingham, AL 35294 USA.
Habermann, Thomas M. (författare)
Mayo Clin, Dept Med, Rochester, MN USA.
Link, Brian K. (författare)
Univ Iowa, Dept Internal Med, Carver Coll Med, Iowa City, IA 52242 USA.
Novak, Anne J. (författare)
Mayo Clin, Dept Med, Rochester, MN USA.
Dogan, Ahmet (författare)
Mem Sloan Kettering Canc Ctr, Dept Lab Med, 1275 York Ave, New York, NY 10021 USA.;Mem Sloan Kettering Canc Ctr, Dept Pathol, 1275 York Ave, New York, NY 10021 USA.
Asmann, Yan W. (författare)
Mayo Clin, Dept Hlth Sci Res, Div Biomed Stat & Informat, Rochester, MN USA.
Liebow, Mark (författare)
Mayo Clin, Dept Med, Rochester, MN USA.
Thompson, Carrie A. (författare)
Mayo Clin, Dept Med, Rochester, MN USA.
Ansell, Stephen M. (författare)
Mayo Clin, Dept Med, Rochester, MN USA.
Witzig, Thomas E. (författare)
Mayo Clin, Dept Med, Rochester, MN USA.
Tilly, Herve (författare)
Univ Rouen, Ctr Henri Becquerel, Rouen, France.
Haioun, Corinne (författare)
Henri Mondor Hosp, Lymphoid Malignancies Unit, Creteil, France.;Univ Paris Est, Creteil, France.
Molina, Thierry J. (författare)
Sorbonne Paris Cite, Univ Paris Descartes, AP HP, Dept Pathol,Necker Enfants Malad, Paris, France.
Uppsala universitet,Experimentell och klinisk onkologi
Adami, Hans-Olov (författare)
Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA.;Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden.
Roos, Goran (författare)
Umea Univ, Dept Med Biosci, Umea, Sweden.
Bracci, Paige M. (författare)
Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA 94143 USA.
Riby, Jacques (författare)
Univ Alabama Birmingham, Sch Publ Hlth, Dept Epidemiol, Birmingham, AL 35294 USA.;Univ Alabama Birmingham, Ctr Comprehens Canc, Birmingham, AL 35294 USA.;Univ Calif Berkeley, Sch Publ Hlth, Div Environm Hlth Sci, Berkeley, CA 94720 USA.
Smith, Martyn T. (författare)
Univ Calif Berkeley, Sch Publ Hlth, Div Environm Hlth Sci, Berkeley, CA 94720 USA.
Holly, Elizabeth A. (författare)
Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA 94143 USA.
Cozen, Wendy (författare)
Univ So Calif, Keck Sch Med, Dept Prevent Med, Los Angeles, CA 90033 USA.;Univ So Calif, Keck Sch Med, Kenneth Norris Jr Comprehens Canc Ctr, Los Angeles, CA 90033 USA.
Hartge, Patricia (författare)
NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA.
Morton, Lindsay M. (författare)
NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA.
Severson, Richard K. (författare)
Wayne State Univ, Dept Family Med & Publ Hlth Sci, Detroit, MI USA.
Tinker, Lesley F. (författare)
Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA.
North, Kari E. (författare)
Univ N Carolina, Dept Epidemiol, Chapel Hill, NC USA.;Univ N Carolina, Carolina Ctr Genome Sci, Chapel Hill, NC USA.
Becker, Nikolaus (författare)
German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Baden Wurttembe, Germany.
Evidence from a small number of studies suggests that longer telomere length measured in peripheral leukocytes is associated with an increased risk of non-Hodgkin lymphoma (NHL). However, these studies may be biased by reverse causation, confounded by unmeasured environmental exposures and might miss time points for which prospective telomere measurement would best reveal a relationship between telomere length and NHL risk. We performed an analysis of genetically inferred telomere length and NHL risk in a study of 10 102 NHL cases of the four most common B-cell histologic types and 9562 controls using a genetic risk score (GRS) comprising nine telomere length-associated single-nucleotide polymorphisms. This approach uses existing genotype data and estimates telomere length by weighing the number of telomere length-associated variant alleles an individual carries with the published change in kb of telomere length. The analysis of the telomere length GRS resulted in an association between longer telomere length and increased NHL risk [four B-cell histologic types combined; odds ratio (OR) = 1.49, 95% CI 1.22-1.82, P-value = 8.5 x 10(-5)]. Subtype-specific analyses indicated that chronic lymphocytic leukemia or small lymphocytic lymphoma (CLL/SLL) was the principal NHL subtype contributing to this association (OR = 2.60, 95% CI 1.93-3.51, P-value = 4.0 x 10(-10)). Significant interactions were observed across strata of sex for CLL/SLL and marginal zone lymphoma subtypes as well as age for the follicular lymphoma subtype. Our results indicate that a genetic background that favors longer telomere length may increase NHL risk, particularly risk of CLL/SLL, and are consistent with earlier studies relating longer telomere length with increased NHL risk.
Ämnesord
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper (hsv//swe)
MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Basic Medicine (hsv//eng)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)