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Sökning: onr:"swepub:oai:DiVA.org:uu-298082" > Blood-Pressure Lowe...

Blood-Pressure Lowering in Intermediate-Risk Persons without Cardiovascular Disease

Lonn, Eva M. (författare)
McMaster Univ, Hamilton Hlth Sci, Populat Hlth Res Inst, Hamilton, ON, Canada.;McMaster Univ, Dept Med, Hamilton, ON, Canada.
Bosch, Jackie (författare)
McMaster Univ, Hamilton Hlth Sci, Populat Hlth Res Inst, Hamilton, ON, Canada.;McMaster Univ, Sch Rehabil Sci, Hamilton, ON, Canada.
Lopez-Jaramillo, Patricio (författare)
Univ Santander, Fdn Oftalmol Santander, Bucaramanga, Colombia.;Univ Santander, Sch Med, Inst Masira, Bucaramanga, Colombia.
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Zhu, Jun (författare)
Chinese Acad Med Sci, Fu Wai Hosp, Beijing 100730, Peoples R China.;Peking Union Med Coll, Beijing 100021, Peoples R China.
Liu, Lisheng (författare)
Chinese Acad Med Sci, Fu Wai Hosp, Beijing 100730, Peoples R China.;Peking Union Med Coll, Beijing 100021, Peoples R China.
Pais, Prem (författare)
St Johns Res Inst, Bangalore, Karnataka, India.
Diaz, Rafael (författare)
Inst Cardiovasc Rosario, Rosario, Santa Fe, Argentina.
Xavier, Denis (författare)
St Johns Res Inst, Bangalore, Karnataka, India.;St Johns Med Coll, Bangalore, Karnataka, India.
Sliwa, Karen (författare)
Univ Cape Town, Soweto Cardiovasc Res Grp, Dept Med, Hatter Inst Cardiovasc Res Africa, ZA-7925 Cape Town, South Africa.
Dans, Antonio (författare)
Univ Philippines, Coll Med, Manila, Philippines.
Avezum, Alvaro (författare)
Dante Pazzanese Inst Cardiol, Sao Paulo, Brazil.
Piegas, Leopoldo S. (författare)
HCor Heart Hosp, Sao Paulo, Brazil.
Keltai, Katalin (författare)
Semmelweis Univ, Hungarian Inst Cardiol, H-1085 Budapest, Hungary.
Keltai, Matyas (författare)
Semmelweis Univ, Hungarian Inst Cardiol, H-1085 Budapest, Hungary.
Chazova, Irina (författare)
Inst Clin Cardiol, Russian Cardiol Res Complex, Moscow, Russia.
Peters, Ron J. G. (författare)
Univ Amsterdam, Acad Med Ctr, Dept Cardiol, Meibergdreef 9, NL-1105 AZ Amsterdam, Netherlands.
Held, Claes (författare)
Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR)
Yusoff, Khalid (författare)
Univ Teknol Majlis Amansh Rakyat, Selayang, Malaysia.;Univ Coll Sedaya Int Univ, Kuala Lumpur, Malaysia.
Lewis, Basil S. (författare)
Technion Israel Inst Technol, Lady Davis Carmel Med Ctr, Ruth & Bruce Rappaport Sch Med, Haifa, Israel.
Jansky, Petr (författare)
Univ Hosp Motol, Prague, Czech Republic.
Parkhomenko, Alexander (författare)
Inst Cardiol, Kiev, Ukraine.
Khunti, Kamlesh (författare)
Univ Leicester, Diabet Res Ctr, Leicester, Leics, England.
Toff, William D. (författare)
Univ Leicester, Dept Cardiovasc Sci, Leicester, Leics, England.;Glenfield Hosp, Leicester Cardiovasc Biomed Res Unit, Natl Inst Hlth Res, Leicester, Leics, England.
Reid, Christopher M. (författare)
Monash Univ, Monash Ctr Cardiovasc Res & Educ Therapeut, Primary Care Diabet & Vasc Med, Melbourne, Vic 3004, Australia.;Curtin Univ, Sch Publ Hlth, Perth, WA 6845, Australia.
Varigos, John (författare)
Monash Univ, Dept Epidemiol & Prevent Med, Melbourne, Vic 3004, Australia.
Leiter, Lawrence A. (författare)
Univ Toronto, St Michaels Hosp, Li Ka Shing Knowledge Inst, Toronto, ON, Canada.;Univ Toronto, St Michaels Hosp, Keenan Res Ctr Biomed Sci, Toronto, ON, Canada.
Molina, Dora I. (författare)
Univ Caldas, Manizales, Colombia.;Inst Prestadora Salud Internistas Caldas, Manizales, Colombia.
McKelvie, Robert (författare)
McMaster Univ, Hamilton Hlth Sci, Populat Hlth Res Inst, Hamilton, ON, Canada.;McMaster Univ, Dept Med, Hamilton, ON, Canada.
Pogue, Janice (författare)
McMaster Univ, Hamilton Hlth Sci, Populat Hlth Res Inst, Hamilton, ON, Canada.;McMaster Univ, Dept Clin Epidemiol & Biostat, Hamilton, ON, Canada.
Wilkinson, Joanne (författare)
McMaster Univ, Hamilton Hlth Sci, Populat Hlth Res Inst, Hamilton, ON, Canada.
Jung, Hyejung (författare)
McMaster Univ, Hamilton Hlth Sci, Populat Hlth Res Inst, Hamilton, ON, Canada.
Dagenais, Gilles (författare)
Univ Laval, Inst Univ Cardiol & Pneumol Quebec, Quebec City, PQ, Canada.
Yusuf, Salim (författare)
McMaster Univ, Hamilton Hlth Sci, Populat Hlth Res Inst, Hamilton, ON, Canada.;McMaster Univ, Dept Med, Hamilton, ON, Canada.
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McMaster Univ, Hamilton Hlth Sci, Populat Hlth Res Inst, Hamilton, ON, Canada;McMaster Univ, Dept Med, Hamilton, ON, Canada. McMaster Univ, Hamilton Hlth Sci, Populat Hlth Res Inst, Hamilton, ON, Canada.;McMaster Univ, Sch Rehabil Sci, Hamilton, ON, Canada. (creator_code:org_t)
2016
2016
Engelska.
Ingår i: New England Journal of Medicine. - 0028-4793 .- 1533-4406. ; 374:21, s. 2009-2020
Relaterad länk:
https://urn.kb.se/re...
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https://doi.org/10.1...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • BACKGROUND Antihypertensive therapy reduces the risk of cardiovascular events among high-risk persons and among those with a systolic blood pressure of 160 mm Hg or higher, but its role in persons at intermediate risk and with lower blood pressure is unclear.METHODS In one comparison from a 2-by-2 factorial trial, we randomly assigned 12,705 participants at intermediate risk who did not have cardiovascular disease to receive either candesartan at a dose of 16 mg per day plus hydrochlorothiazide at a dose of 12.5 mg per day or placebo. The first coprimary outcome was the composite of death from cardiovascular causes, nonfatal myocardial infarction, or nonfatal stroke; the second coprimary outcome additionally included resuscitated cardiac arrest, heart failure, and revascularization. The median follow-up was 5.6 years.RESULTS The mean blood pressure of the participants at baseline was 138.1/81.9 mm Hg; the decrease in blood pressure was 6.0/3.0 mm Hg greater in the active-treatment group than in the placebo group. The first coprimary outcome occurred in 260 participants (4.1%) in the active-treatment group and in 279 (4.4%) in the placebo group (hazard ratio, 0.93; 95% confidence interval [CI], 0.79 to 1.10; P = 0.40); the second coprimary outcome occurred in 312 participants (4.9%) and 328 participants (5.2%), respectively (hazard ratio, 0.95; 95% CI, 0.81 to 1.11; P = 0.51). In one of the three prespecified hypothesis-based subgroups, participants in the subgroup for the upper third of systolic blood pressure (>143.5 mm Hg) who were in the active-treatment group had significantly lower rates of the first and second coprimary outcomes than those in the placebo group; effects were neutral in the middle and lower thirds (P = 0.02 and P = 0.009, respectively, for trend in the two outcomes).CONCLUSIONS Therapy with candesartan at a dose of 16 mg per day plus hydrochlorothiazide at a dose of 12.5 mg per day was not associated with a lower rate of major cardiovascular events than placebo among persons at intermediate risk who did not have cardiovascular disease. ( ClinicalTrials. gov number, NCT00468923.)

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