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Protein folding :
Protein folding : Vexing debates on a fundamental problem
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- Gianni, Stefano (författare)
- Univ Rome, Ist Pasteur, Fdn Cenci Bolognetti, I-00185 Rome, Italy.;Univ Rome, Dipartimento Sci Biochim A Rossi Fanelli Sapienza, Ist Biol & Patol Mol, CNR, I-00185 Rome, Italy.;Univ Cambridge, Dept Chem, Lensfield Rd, Cambridge CB2 1EW, England.
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- Jemth, Per (författare)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi
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Univ Rome, Ist Pasteur, Fdn Cenci Bolognetti, I-00185 Rome, Italy;Univ Rome, Dipartimento Sci Biochim A Rossi Fanelli Sapienza, Ist Biol & Patol Mol, CNR, I-00185 Rome, Italy.;Univ Cambridge, Dept Chem, Lensfield Rd, Cambridge CB2 1EW, England. Institutionen för medicinsk biokemi och mikrobiologi (creator_code:org_t)
- Elsevier BV, 2016
- 2016
- Engelska.
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Ingår i: Biophysical Chemistry. - : Elsevier BV. - 0301-4622 .- 1873-4200. ; 212, s. 17-21
- Relaterad länk:
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https://urn.kb.se/re...
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visa fler...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- The folding of proteins has been at the heart of protein chemistry and biophysics ever since the pioneering experiments by the labs of Fred Richards and Christian Anfinsen. But, despite nearly 60 years of intense research, there are unresolved issues and a lively debate regarding some aspects of this fundamental problem. In this review we give a personal account on some key topics in the field: (i) the nature of the denatured state of a protein, (ii) nucleation sites in the folding reaction, and (iii) the time it takes for individual molecules to traverse the transition state.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Medicinsk bioteknologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Medical Biotechnology (hsv//eng)
Nyckelord
- Protein folding
- Kinetics
- Mutagenesis
- Denatured state
- Transition state
- Transition path time
Publikations- och innehållstyp
- ref (ämneskategori)
- for (ämneskategori)
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