Platelet-Related Variants Identified by Exomechip Meta-analysis in 157,293 Individuals

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Platelet-Related Variants Identified by Exomechip Meta-analysis in 157,293 Individuals

Eicher, John D. (författare): NHLBI, Populat Sci Branch, Framingham Heart Study, Framingham, MA 01702 USA.;Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Seattle, WA 98109 USA.

Chami, Nathalie (författare): Univ Montreal, Dept Med, Montreal, PQ H3T 1J4, Canada.;Montreal Heart Inst, Montreal, PQ H1T 1C8, Canada.;Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Seattle, WA 98109 USA.

Kacprowski, Tim (författare): Univ Med Greifswald, Interfac Inst Genet & Funct Genom, Dept Funct Genom, D-17475 Greifswald, Germany.;Ernst Mortiz Arndt Univ Greifswald, D-17475 Greifswald, Germany.;DZHK German Ctr Cardiovasc Res, Partner Site Greifswald, Greifswald, Germany.;Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Seattle, WA 98109 USA.

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Nomura, Akihiro (författare): Massachusetts Gen Hosp, Ctr Human Genet Res, Boston, MA 02114 USA.;Broad Inst, Program Med & Populat Genet, Cambridge, MA 02142 USA.;Massachusetts Gen Hosp, Cardiovasc Res Ctr, Boston, MA 02114 USA.;Harvard Med Sch, Dept Med, Boston, MA 02115 USA.;Kanazawa Univ, Div Cardiovasc Med, Grad Sch Med Sci, Kanazawa, Ishikawa 9200942, Japan.;Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Seattle, WA 98109 USA.

Chen, Ming-Huei (författare): NHLBI, Populat Sci Branch, Framingham Heart Study, Framingham, MA 01702 USA.

Yanek, Lisa R. (författare): Johns Hopkins Univ, Div Gen Internal Med, Dept Med, Sch Med, Baltimore, MD 21205 USA.

Tajuddin, Salman M. (författare): NIA, Lab Epidemiol & Populat Sci, NIH, Baltimore, MD 21224 USA.

Schick, Ursula M. (författare): Icahn Sch Med Mt Sinai, Charles Bronfman Inst Personalized Med, New York, NY 10029 USA.;Icahn Sch Med Mt Sinai, Genet Obes & Related Metab Traits Program, New York, NY 10029 USA.

Slater, Andrew J. (författare): GlaxoSmithKline, Genet, Target Sci, Res Triangle Pk, NC 27709 USA.;OmicSoft Corp, Cary, NC 27513 USA.

Pankratz, Nathan (författare): Univ Minnesota, Dept Lab Med & Pathol, Minneapolis, MN 55454 USA.

Polfus, Linda (författare): Univ Texas Hlth Sci Ctr Houston, Sch Publ Hlth, Ctr Human Genet, Houston, TX 77030 USA.

Schurmann, Claudia (författare): Icahn Sch Med Mt Sinai, Charles Bronfman Inst Personalized Med, New York, NY 10029 USA.;Icahn Sch Med Mt Sinai, Genet Obes & Related Metab Traits Program, New York, NY 10029 USA.

Giri, Ayush (författare): Vanderbilt Univ, Inst Med & Publ Hlth, Div Epidemiol, Nashville, TN 37235 USA.

Brody, Jennifer A. (författare): Univ Washington, Dept Med, Seattle, WA 98101 USA.

Lange, Leslie A. (författare): Univ N Carolina, Dept Genet, Chapel Hill, NC 27514 USA.

Manichaikul, Ani (författare): Univ Virginia, Ctr Publ Hlth Gen, Charlottesville, VA 22908 USA.

Hill, W. David (författare): Univ Edinburgh, Ctr Cognit Ageing & Cognit Epidemiol, Edinburgh EH8 9JZ, Midlothian, Scotland.;Univ Edinburgh, Dept Psychol, Edinburgh EH8 9JZ, Midlothian, Scotland.

Pazoki, Raha (författare): Erasmus MC, Dept Epidemiol, NL-3000 Rotterdam, Netherlands.

Elliot, Paul (författare): Univ London Imperial Coll Sci Technol & Med, MRC PHE Ctr Environm & Hlth, Dept Epidemiol & Biostat, Sch Publ Hlth, London W2 1PG, England.

Evangelou, Evangelos (författare): Univ London Imperial Coll Sci Technol & Med, MRC PHE Ctr Environm & Hlth, Dept Epidemiol & Biostat, Sch Publ Hlth, London W2 1PG, England.;Univ Ioannina, Dept Hyg & Epidemiol, Sch Med, Ioannina 45110, Greece.

Tzoulaki, Ioanna (författare): Univ London Imperial Coll Sci Technol & Med, MRC PHE Ctr Environm & Hlth, Dept Epidemiol & Biostat, Sch Publ Hlth, London W2 1PG, England.;Univ Ioannina, Dept Hyg & Epidemiol, Sch Med, Ioannina 45110, Greece.

Gao, He (författare): Univ London Imperial Coll Sci Technol & Med, MRC PHE Ctr Environm & Hlth, Dept Epidemiol & Biostat, Sch Publ Hlth, London W2 1PG, England.

Vergnaud, Anne-Claire (författare): Univ London Imperial Coll Sci Technol & Med, MRC PHE Ctr Environm & Hlth, Dept Epidemiol & Biostat, Sch Publ Hlth, London W2 1PG, England.

Mathias, Rasika A. (författare): Johns Hopkins Univ, Div Gen Internal Med, Dept Med, Sch Med, Baltimore, MD 21205 USA.;Johns Hopkins Univ, Sch Med, Dept Med, Div Allergy, Baltimore, MD 21205 USA.;Johns Hopkins Univ, Sch Med, Dept Med, Div Immunol, Baltimore, MD 21205 USA.

Becker, Diane M. (författare): Johns Hopkins Univ, Div Gen Internal Med, Dept Med, Sch Med, Baltimore, MD 21205 USA.

Becker, Lewis C. (författare): Johns Hopkins Univ, Div Gen Internal Med, Dept Med, Sch Med, Baltimore, MD 21205 USA.;Johns Hopkins Univ, Div Cardiol, Dept Med, Sch Med, Baltimore, MD 21205 USA.

Burt, Amber (författare): Univ Washington, Div Med Genet, Dept Med, Seattle, WA 98195 USA.

Crosslin, David R. (författare): Univ Washington, Dept Biomed Informat & Med Educ, Seattle, WA 98105 USA.

Lyytikainen, Leo-Pekka (författare): Fimlab Labs, Dept Clin Chem, Tampere 33520, Finland.;Univ Tampere, Dept Clin Chem, Sch Med, Tampere 33514, Finland.

Nikus, Kjell (författare): Tampere Univ Hosp, Dept Cardiol, Ctr Heart, Tampere 33521, Finland.;Univ Tampere, Sch Med, Tampere 33514, Finland.

Hernesniemi, Jussi (författare): Fimlab Labs, Dept Clin Chem, Tampere 33520, Finland.;Univ Tampere, Dept Clin Chem, Sch Med, Tampere 33514, Finland.;Tampere Univ Hosp, Dept Cardiol, Ctr Heart, Tampere 33521, Finland.

Kahonen, Mika (författare): Tampere Univ Hosp, Dept Clin Physiol, Tampere 33521, Finland.;Univ Tampere, Dept Clin Physiol, Tampere 33514, Finland.

Raitoharju, Emma (författare): Fimlab Labs, Dept Clin Chem, Tampere 33520, Finland.;Univ Tampere, Dept Clin Chem, Sch Med, Tampere 33514, Finland.

Mononen, Nina (författare): Fimlab Labs, Dept Clin Chem, Tampere 33520, Finland.;Univ Tampere, Dept Clin Chem, Sch Med, Tampere 33514, Finland.

Raitakari, Olli T. (författare): Turku Univ Hosp, Dept Clin Physiol & Nucl Med, Turku 20521, Finland.;Univ Turku, Res Ctr Appl & Prevent Cardiovasc Med, FIN-20520 Turku, Finland.

Lehtimaki, Terho (författare): Fimlab Labs, Dept Clin Chem, Tampere 33520, Finland.;Univ Tampere, Dept Clin Chem, Sch Med, Tampere 33514, Finland.

Cushman, Mary (författare): Univ Vermont, Coll Med, Dept Med, Burlington, VT 05405 USA.;Univ Vermont, Coll Med, Dept Pathol, Burlington, VT 05405 USA.

Zakai, Neil A. (författare): Univ Vermont, Coll Med, Dept Med, Burlington, VT 05405 USA.;Univ Vermont, Coll Med, Dept Pathol, Burlington, VT 05405 USA.

Nickerson, Deborah A. (författare): Univ Washington, Dept Genome Sci, Seattle, WA 98105 USA.

Raffield, Laura M. (författare): Univ N Carolina, Dept Genet, Chapel Hill, NC 27514 USA.

Quarells, Rakale (författare): Morehouse Sch Med, Social Epidemiol Res Ctr, Cardiovasc Res Inst, Atlanta, GA 30310 USA.

Willer, Cristen J. (författare): Univ Michigan, Dept Internal Med, Div Cardiovasc Med, Ann Arbor, MI 48108 USA.;Univ Michigan, Dept Computat Med & Bioinformat, Dept Human Genet, Ann Arbor, MI 48108 USA.;Univ Michigan, Dept Biostat, Ann Arbor, MI 48108 USA.

Peloso, Gina M. (författare): Massachusetts Gen Hosp, Ctr Human Genet Res, Boston, MA 02114 USA.;Broad Inst, Program Med & Populat Genet, Cambridge, MA 02142 USA.;Boston Univ, Dept Biostat, Sch Publ Hlth, Boston, MA 02118 USA.

Abecasis, Goncalo R. (författare): Univ Michigan, Dept Biostat, Ctr Stat Genet, Ann Arbor, MI 48108 USA.

Liu, Dajiang J. (författare): Penn State Univ Hosp, Dept Publ Hlth Sci, Coll Med, Hershey, PA 17033 USA.

Deloukas, Panos (författare): Queen Mary Univ London, William Harvey Res Inst, London E1 4NS, England.;King Abdulaziz Univ, Princess Al Jawhara Al Brahim Ctr Excellence Res, Jeddah 21589, Saudi Arabia.

Samani, Nilesh J. (författare): Univ Leicester, Dept Cardiovasc Sci, Leicester LE1 7RH, Leics, England.;Glenfield Hosp, NIHR Leicester Cardiovasc Biomed Res Unit, Leicester LE3 9QP, Leics, England.

Schunkert, Heribert (författare): DZHK German Ctr Cardiovasc Res, Partner Site Munich Heart Alliance, D-80333 Munich, Germany.;Tech Univ Munich, Deutsch Herzzentrum Munchen, D-80333 Munich, Germany.

Erdmann, Jeanette (författare): Univ Lubeck, Inst Integrat & Expt Genom, D-23562 Lubeck, Germany.;DZHK German Res Ctr Cardiovasc Res, Partner Site Hamburg Lubeck Kiel, D-23562 Lubeck, Germany.

Fornage, Myriam (författare): Univ Texas Hlth Sci Ctr Houston, Inst Mol Med, Houston, TX 77030 USA.

Richard, Melissa (författare): Univ Texas Hlth Sci Ctr Houston, Inst Mol Med, Houston, TX 77030 USA.

Tardif, Jean-Claude (författare): Univ Montreal, Dept Med, Montreal, PQ H3T 1J4, Canada.;Montreal Heart Inst, Montreal, PQ H1T 1C8, Canada.

Rioux, John D. (författare): Univ Montreal, Dept Med, Montreal, PQ H3T 1J4, Canada.;Montreal Heart Inst, Montreal, PQ H1T 1C8, Canada.

Dube, Marie-Pierre (författare): Univ Montreal, Dept Med, Montreal, PQ H3T 1J4, Canada.;Montreal Heart Inst, Montreal, PQ H1T 1C8, Canada.

de Denus, Simon (författare): Montreal Heart Inst, Montreal, PQ H1T 1C8, Canada.;Univ Montreal, Fac Pharm, Montreal H3T 1J4, PQ, Canada.

Lu, Yingchang (författare): Icahn Sch Med Mt Sinai, Charles Bronfman Inst Personalized Med, New York, NY 10029 USA.

Bottinger, Erwin P. (författare): Icahn Sch Med Mt Sinai, Charles Bronfman Inst Personalized Med, New York, NY 10029 USA.

Loos, Ruth J. F. (författare): Icahn Sch Med Mt Sinai, Charles Bronfman Inst Personalized Med, New York, NY 10029 USA.

Smith, Albert Vernon (författare): Icelandic Heart Assoc, IS-201 Kopavogur, Iceland.;Univ Iceland, Fac Med, IS-101 Reykjavik, Iceland.

Harris, Tamara B. (författare): NIA, Lab Epidemiol Demog & Biometry, Intramural Res Program, NIH, Baltimore, MD 21224 USA.

Launer, Lenore J. (författare): NIA, Lab Epidemiol Demog & Biometry, Intramural Res Program, NIH, Baltimore, MD 21224 USA.

Gudnason, Vilmundur (författare): Icelandic Heart Assoc, IS-201 Kopavogur, Iceland.;Univ Iceland, Fac Med, IS-101 Reykjavik, Iceland.

Edwards, Digna R. Velez (författare): Vanderbilt Univ, Vanderbilt Epidemiol Ctr, Dept Obstet & Gynecol, Inst Med & Publ Hlth,Vanderbilt Genet Inst, Nashville, TN 37203 USA.

Torstenson, Eric S. (författare): Vanderbilt Univ, Inst Med & Publ Hlth, Div Epidemiol, Nashville, TN 37235 USA.

Liu, Yongmei (författare): Wake Forest Sch Med, Div Publ Hlth Sci, Ctr Human Genet, Winston Salem, NC 27157 USA.

Tracy, Russell P. (författare): Univ Vermont, Coll Med, Dept Pathol & Lab Med, Colchester, VT 05446 USA.;Univ Vermont, Coll Med, Dept Biochem, Colchester, VT 05446 USA.

Rotter, Jerome I. (författare): Los Angeles Biomed Res Inst, Inst Translat Genom & Populat Sci, Torrance, CA 90502 USA.;Harbor UCLA Med Ctr, Dept Pediat, Torrance, CA 90502 USA.

Rich, Stephen S. (författare): Univ Virginia, Ctr Publ Hlth Gen, Charlottesville, VA 22908 USA.

Highland, Heather M. (författare): Univ Texas Hlth Sci Ctr Houston, Univ Texas Grad Sch Biomed Sci Houston, Univ Texas Sch Publ Hlth, Houston, TX 77030 USA.;Univ N Carolina, Dept Epidemiol, Chapel Hill, NC 27514 USA.

Boerwinkle, Eric (författare): Univ Texas Hlth Sci Ctr Houston, Sch Publ Hlth, Ctr Human Genet, Houston, TX 77030 USA.;Baylor Coll Med, Human Genome Sequencing Ctr, Houston, TX 77030 USA.

Li, Jin (författare): Stanford Univ, Sch Med, Dept Med, Div Cardiovasc Med, Palo Alto, CA 94305 USA.

Lange, Ethan (författare): Univ N Carolina, Dept Genet, Chapel Hill, NC 27514 USA.;Univ N Carolina, Dept Biostat, Chapel Hill, NC 27514 USA.

Wilson, James G. (författare): Univ Mississippi, Dept Physiol & Biophys, Med Ctr, Jackson, MS 39216 USA.

Mihailov, Evelin (författare): Univ Tartu, Estonian Genome Ctr, EE-51010 Tartu, Estonia.

Magi, Reedik (författare): Univ Tartu, Estonian Genome Ctr, EE-51010 Tartu, Estonia.

Hirschhorn, Joel (författare): Broad Inst, Program Med & Populat Genet, Cambridge, MA 02142 USA.;Boston Childrens Hosp, Dept Endocrinol, Boston, MA 02115 USA.

Metspalu, Andres (författare): Univ Tartu, Estonian Genome Ctr, EE-51010 Tartu, Estonia.

Esko, Tonu (författare): Broad Inst, Program Med & Populat Genet, Cambridge, MA 02142 USA.;Univ Tartu, Estonian Genome Ctr, EE-51010 Tartu, Estonia.

Vacchi-Suzzi, Caterina (författare): SUNY Stony Brook, Dept Family Populat & Prevent Med, Stony Brook, NY 11794 USA.

Nalls, Mike A. (författare): NIA, Neurogenet Lab, NIH, Bethesda, MD 21224 USA.

Zonderman, Alan B. (författare): NIA, Lab Epidemiol & Populat Sci, NIH, Baltimore, MD 21224 USA.

Evans, Michele K. (författare): NIA, Lab Epidemiol & Populat Sci, NIH, Baltimore, MD 21224 USA.

Engstrom, Gunnar (författare): Lund Univ, Dept Clin Sci Malmo, S-22100 Malmo, Sweden.;Skane Univ Hosp, S-22241 Malmo, Sweden.

Orho-Melander, Marju (författare): Lund Univ, Dept Clin Sci Malmo, S-22100 Malmo, Sweden.;Skane Univ Hosp, S-22241 Malmo, Sweden.

Melander, Olle (författare): Lund Univ, Dept Clin Sci Malmo, S-22100 Malmo, Sweden.;Skane Univ Hosp, S-22241 Malmo, Sweden.

O'Donoghue, Michelle L. (författare): Brigham & Womens Hosp, TIMI Study Grp, Div Cardiovasc, Boston, MA 02115 USA.

Waterworth, Dawn M. (författare): GlaxoSmithKline, Target Sci, Genet, King Of Prussia, PA 19406 USA.

Wallentin, Lars (författare): Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR)

White, Harvey D. (författare): Auckland City Hosp, Green Lane Cardiovasc Serv, Auckland 1142, New Zealand.;Univ Auckland, Auckland 1142, New Zealand.

Floyd, James S. (författare): Univ Washington, Dept Med, Seattle, WA 98101 USA.

Bartz, Traci M. (författare): Univ Washington, Dept Biostat, Seattle, WA 98195 USA.

Rice, Kenneth M. (författare): Univ Washington, Dept Biostat, Seattle, WA 98195 USA.

Psaty, Bruce M. (författare): Univ Washington, Dept Med, Cardiovasc Hlth Res Unit, Seattle, WA 98101 USA.;Univ Washington, Dept Epidemiol, Seattle, WA 98101 USA.;Univ Washington, Dept Hlth Serv, Seattle, WA 98101 USA.;Grp Hlth Res Inst, Grp Hlth Cooperat, Seattle, WA 98101 USA.

Starr, J. M. (författare): Univ Edinburgh, Ctr Cognit Ageing & Cognit Epidemiol, Edinburgh EH8 9JZ, Midlothian, Scotland.;Alzheimer Scotland Res Ctr, Edinburgh EH8 9JZ, Midlothian, Scotland.

Liewald, David C. M. (författare): Univ Edinburgh, Ctr Cognit Ageing & Cognit Epidemiol, Edinburgh EH8 9JZ, Midlothian, Scotland.;Univ Edinburgh, Dept Psychol, Edinburgh EH8 9JZ, Midlothian, Scotland.

Hayward, Caroline (författare): Univ Edinburgh, MRC Human Genet Unit, Inst Genet & Mol Med, Edinburgh EH4 2XU, Midlothian, Scotland.

Deary, Ian J. (författare): Univ Edinburgh, Ctr Cognit Ageing & Cognit Epidemiol, Edinburgh EH8 9JZ, Midlothian, Scotland.;Univ Edinburgh, Dept Psychol, Edinburgh EH8 9JZ, Midlothian, Scotland.

Greinacher, Andreas (författare): Univ Med Greifswald, Inst Immunol & Transfus Med, D-17475 Greifswald, Germany.

Volker, Uwe (författare): Univ Med Greifswald, Interfac Inst Genet & Funct Genom, Dept Funct Genom, D-17475 Greifswald, Germany.;Ernst Mortiz Arndt Univ Greifswald, D-17475 Greifswald, Germany.;DZHK German Ctr Cardiovasc Res, Partner Site Greifswald, Greifswald, Germany.

Thiele, Thomas (författare): Univ Med Greifswald, Inst Immunol & Transfus Med, D-17475 Greifswald, Germany.

Volzke, Henry (författare): DZHK German Ctr Cardiovasc Res, Partner Site Greifswald, Greifswald, Germany.;Univ Med Greifswald, Inst Community Med, D-13347 Greifswald, Germany.

van Rooij, Frank J. A. (författare): Erasmus MC, Dept Epidemiol, NL-3000 Rotterdam, Netherlands.

Uitterlinden, Andre G. (författare): Erasmus MC, Dept Epidemiol, NL-3000 Rotterdam, Netherlands.;Erasmus MC, Dept Internal Med, NL-3000 Rotterdam, Netherlands.;Netherlands Consortium Hlth Ageing, NL-3015 Rotterdam, Netherlands.

Franco, Oscar H. (författare): Erasmus MC, Dept Epidemiol, NL-3000 Rotterdam, Netherlands.

Dehghan, Abbas (författare): Erasmus MC, Dept Epidemiol, NL-3000 Rotterdam, Netherlands.

Edwards, Todd L. (författare): Vanderbilt Univ, Inst Med & Publ Hlth, Div Epidemiol, Nashville, TN 37235 USA.

Ganesh, Santhi K. (författare): Univ Michigan, Dept Internal & Human Genet, Ann Arbor, MI 48108 USA.

Kathiresan, Sekar (författare): Massachusetts Gen Hosp, Ctr Human Genet Res, Boston, MA 02114 USA.;Broad Inst, Program Med & Populat Genet, Cambridge, MA 02142 USA.;Massachusetts Gen Hosp, Cardiovasc Res Ctr, Boston, MA 02114 USA.;Harvard Med Sch, Dept Med, Boston, MA 02115 USA.

Faraday, Nauder (författare): Johns Hopkins Univ, Sch Med, Dept Anesthesiol & Crit Care Med, Baltimore, MD 21205 USA.;Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Seattle, WA 98109 USA.

Auer, Paul L. (författare): Univ Wisconsin, Zilber Sch Publ Hlth, Milwaukee, WI 53205 USA.;Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Seattle, WA 98109 USA.

Reiner, Alex P. (författare): Univ Washington, Dept Epidemiol, Seattle, WA 98105 USA.;Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Seattle, WA 98109 USA.

Lettre, Guillaume (författare): Univ Montreal, Dept Med, Montreal, PQ H3T 1J4, Canada.;Montreal Heart Inst, Montreal, PQ H1T 1C8, Canada.;Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Seattle, WA 98109 USA.

Johnson, Andrew D. (författare): NHLBI, Populat Sci Branch, Framingham Heart Study, Framingham, MA 01702 USA.;Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Seattle, WA 98109 USA.

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NHLBI, Populat Sci Branch, Framingham Heart Study, Framingham, MA 01702 USA;Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Seattle, WA 98109 USA. Univ Montreal, Dept Med, Montreal, PQ H3T 1J4, Canada.;Montreal Heart Inst, Montreal, PQ H1T 1C8, Canada.;Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Seattle, WA 98109 USA. (creator_code:org_t)

2016
2016
Engelska.
Ingår i: American Journal of Human Genetics. - 0002-9297 .- 1537-6605. ; 99:1, s. 40-55

Relaterad länk:: https://doi.org/10.1...

Tidskriftsartikel (refereegranskat)

Abstract Ämnesord

Stäng

Platelet production, maintenance, and clearance are tightly controlled processes indicative of platelets' important roles in hemostasis and thrombosis. Platelets are common targets for primary and secondary prevention of several conditions. They are monitored clinically by complete blood counts, specifically with measurements of platelet count (PLT) and mean platelet volume (MPV). Identifying genetic effects on PLT and MPV can provide mechanistic insights into platelet biology and their role in disease. Therefore, we formed the Blood Cell Consortium (BCX) to perform a large-scale meta-analysis of Exomechip association results for PLT and MPV in 157,293 and 57,617 individuals, respectively. Using the low-frequency/rare coding variant-enriched Exomechip genotyping array, we sought to identify genetic variants associated with PLT and MPV. In addition to confirming 47 known PLT and 20 known MPV associations, we identified 32 PLT and 18 MPV associations not previously observed in the literature across the allele frequency spectrum, including rare large effect (FCER1A), low-frequency (IQGAP2, MAP1A, LY75), and common(ZMIZ2, SMG6, PEAR1, ARFGAP3/PACSIN2) variants. Several variants associated with PLT/MPV(PEAR1, MRVI1, PTGES3) were also associated with platelet reactivity. In concurrent BCX analyses, there was overlap of platelet-associated variants with red (MAP1A, TMPRSS6, ZMIZ2) and white (PEAR1, ZMIZ2, LY75) blood cell traits, suggesting common regulatory pathways with shared genetic architecture among these hematopoietic lineages. Our large-scale Exomechip analyses identified previously undocumented associations with platelet traits and further indicate that several complex quantitative hematological, lipid, and cardiovascular traits share genetic factors.