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Salt-Gradient Appro...
Salt-Gradient Approach for Regulating Capture-to-Translocation Dynamics of DNA with Nanochannel Sensors
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- He, Yuhui (författare)
- Huazhong Univ Sci & Technol, Sch Opt & Elect Informat, LuoYu Rd, Wuhan 430074, Peoples R China.
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- Tsutsui, Makusu (författare)
- Osaka Univ, Inst Sci & Ind Res, 8-1 Mihogaoka, Ibaraki, Osaka 5670047, Japan.
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- Scheicher, Ralph H. (författare)
- Uppsala universitet,Materialteori
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- Miao, Xiang Shui (författare)
- Huazhong Univ Sci & Technol, Sch Opt & Elect Informat, LuoYu Rd, Wuhan 430074, Peoples R China.
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- Taniguchi, Masateru (författare)
- Osaka Univ, Inst Sci & Ind Res, 8-1 Mihogaoka, Ibaraki, Osaka 5670047, Japan.
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Huazhong Univ Sci & Technol, Sch Opt & Elect Informat, LuoYu Rd, Wuhan 430074, Peoples R China Osaka Univ, Inst Sci & Ind Res, 8-1 Mihogaoka, Ibaraki, Osaka 5670047, Japan. (creator_code:org_t)
- 2016-05-24
- 2016
- Engelska.
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Ingår i: ACS Sensors. - : American Chemical Society (ACS). - 2379-3694. ; 1:6, s. 807-816
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Understanding the physical mechanisms that govern the ion and fluidic transport in salt-concentration-based nanochannel/nanopore systems is essential for the potential applications in bioanalysis. One central challenge is to interpret the observed four-stage change from osmosis to the reverse one with increasing salt gradient. Here we provide a unified model that outlines the intriguing role of two competing factors, the exclusion- and diffusion-induced electrical potentials. We demonstrate theoretically a direction control of a hydrodynamic flow via the salt gradient. Based on this, we also propose a salt-gradient approach for regulating DNA motion in nanochannels that enables voltage-free single-molecule capture with a significantly low translocation speed. The present method would be used as a useful protocol to overcome the key hurdle of tailoring the capture-to-translocation dynamics of polynucleotides for nanopore sequencing.
Nyckelord
- salt gradient
- DNA manipulating
- DNA capture
- nanochannel
- electrokinetic modeling
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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