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The combination of Ki67, histological grade and estrogen receptor status identifies a low-risk group among 1,854 chemo-naive women with N0/N1 primary breast cancer

Strand, Carina, (författare)
Lund Univ, Skane Univ Hosp, Dept Clin Sci Lund, Div Oncol, SE-22185 Lund, Sweden.
Bak, Martin, (författare)
Odense Univ Hosp, Dept Pathol, DK-5000 Odense, Denmark.
Borgquist, Signe, (författare)
Lund Univ, Skane Univ Hosp, Dept Clin Sci Lund, Div Oncol, SE-22185 Lund, Sweden.
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Chebil, Gunilla, (författare)
Unilabs, Mammog, SE-25223 Helsingborg, Sweden.
Falck, Anna-Karin, (författare)
Helsingborg Hosp, Dept Surg, SE-28185 Helsingborg, Sweden.
Fjällskog, Marie-Louise, (författare)
Uppsala universitet, Institutionen för onkologi, radiologi och klinisk immunologi, Uppsala universitet, Onkologisk endokrinologi
Grabau, Dorthe, (författare)
Lund Univ, Skane Univ Hosp, Dept Pathol, SE-22185 Lund, Sweden.
Hedenfalk, Ingrid, (författare)
Lund Univ, Skane Univ Hosp, Dept Clin Sci Lund, Div Oncol, SE-22185 Lund, Sweden.
Jirström, Karin, (författare)
Lund Univ, Dept Clin Sci Lund, Div Pathol, SE-22185 Lund, Sweden.
Klintman, Marie, (författare)
Lund Univ, Skane Univ Hosp, Dept Clin Sci Lund, Div Oncol, SE-22185 Lund, Sweden.
Malmström, Per, (författare)
Lund Univ, Skane Univ Hosp, Dept Clin Sci Lund, Div Oncol, SE-22185 Lund, Sweden.;Skane Univ Hosp, Skane Dept Oncol, SE-22185 Lund, Sweden.
Olsson, Hans, (författare)
Linkoping Univ, Fac Hlth Sci, Cty Council Ostergotland,Mol & Immunol Pathol, Dept Clin Pathol & Clin Genet,Dept Clin & Expt Me, SE-58191 Linkoping, Sweden.
Rydén, Lisa, (författare)
Lund Univ, Skane Univ Hosp, Dept Clin Sci Lund, Div Surg, SE-22185 Lund, Sweden.
Stål, Olle, (författare)
Linkoping Univ, Fac Hlth Sci, Cty Council Ostergotland, Dept Clin & Expt Med,Div Oncol, SE-58185 Linkoping, Sweden.
Bendahl, Pär-Ola, (författare)
Lund Univ, Skane Univ Hosp, Dept Clin Sci Lund, Div Oncol, SE-22185 Lund, Sweden.
Fernö, Mårten, (författare)
Lund Univ, Skane Univ Hosp, Dept Clin Sci Lund, Div Oncol, SE-22185 Lund, Sweden.
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2013
Engelska.
Ingår i: SpringerPlus. - 2193-1801. ; 2
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • <p>Background: The aim was to confirm a previously defined prognostic index, combining a proliferation marker, histological grade, and estrogen receptor (ER) in different subsets of primary N0/N1 chemo-naive breast cancer patients. Methods/design: In the present study, including 1,854 patients, Ki67 was used in the index (KiGE), since it is the generally accepted proliferation marker in clinical routine. The low KiGE-group was defined as histological grade 1 patients and grade 2 patients which were ER-positive and had low Ki67 expression. All other patients made up the high KiGE-group. The KiGE-index separated patients into two groups with different prognosis. In multivariate analysis, KiGE was significantly associated with disease-free survival, when adjusted for age at diagnosis, tumor size and adjuvant endocrine treatment (hazard ratio: 3.5, 95% confidence interval: 2.6-4.7, P&lt;0.0001). Discussion: We have confirmed a prognostic index based on a proliferation marker (Ki67), histological grade, and ER for identification of a low-risk group of patients with N0/N1 primary breast cancer. For this low-risk group constituting 57% of the patients, with a five-year distant disease-free survival of 92%, adjuvant chemotherapy will have limited effect and may be avoided.</p>

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

Nyckelord

Breast cancer
Chemo-naive
Ki67
Prognostic index
Proliferation

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