Ctr Res Epidemiol & Stat Sorbonne Paris Cite CRES, INSERM, Epidemiol Childhood & Adolescent Canc Grp, F-94807 Paris, France.;Univ Paris 05, F-75270 Paris, France.
Topka, Sabine (författare)
Mem Sloan Kettering Canc Ctr, Dept Med, New York, NY 10065 USA.
Spinelli, John J. (författare)
BC Canc Agcy, Canc Control Res, Vancouver, BC V5Z 1L3, Canada.;Univ British Columbia, Sch Populat & Publ Hlth, Vancouver, BC V6T 1Z3, Canada.
Kraft, Peter (författare)
Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA.;Harvard TH Chan Sch Publ Hlth, Dept Biostat, Boston, MA 02115 USA.
Univ North Carolina Chapel Hill, Dept Epidemiol, Chapel Hill, NC 27599 USA.;Univ North Carolina Chapel Hill, Carolina Ctr Genome Sci, Chapel Hill, NC 27599 USA.
Allsup, David J. (författare)
Hull & East Yorkshire NHS Trust, Castle Hill Hosp, Queens Ctr Haematol & Oncol, Cottingham HU16 5JQ, England.
Fraumeni, Joseph F., Jr. (författare)
NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA.
Bailey, James R. (författare)
Hull & East Yorkshire NHS Trust, Castle Hill Hosp, Queens Ctr Haematol & Oncol, Cottingham HU16 5JQ, England.
Offit, Kenneth (författare)
Mem Sloan Kettering Canc Ctr, Dept Med, New York, NY 10065 USA.
Uppsala universitet,Experimentell och klinisk onkologi,Science for Life Laboratory, SciLifeLab
de Sanjose, Silvia (författare)
Icahn Sch Med Mt Sinai, Tisch Canc Inst, New York, NY 10029 USA.;Int Agcy Res Canc, F-69372 Lyon, France.
Carracedo, Angel (författare)
Univ Santiago de Compostela, Grp Med Xenom, Ctr Nacl Genotipado CeGen ISCIII PRB2, CIBERER, Santiago De Compostela 15782, Spain.;King Abdulaziz Univ, CEGMR, Jeddah 21589, Saudi Arabia.
Dyer, Martin J. S. (författare)
Univ Leicester, Ernest & Helen Scott Haematol Res Inst, Leicester LE2 7LX, Leics, England.
Catovsky, Daniel (författare)
Inst Canc Res, Div Mol Pathol, London SW7 3RP, England.
Campo, Elias (författare)
Hosp Clin Barcelona, Inst Invest Biomed August Pi ISunyer IDIBAPS, Barcelona 08036, Spain.;Univ Barcelona, Unitat Hematol, Hosp Clin, IDIBAPS, E-08036 Barcelona, Spain.
Cerhan, James R. (författare)
Mayo Clin, Dept Hlth Sci Res, Rochester, MN 55905 USA.
Several chronic lymphocytic leukaemia (CLL) susceptibility loci have been reported; however, much of the heritable risk remains unidentified. Here we perform a meta-analysis of six genome-wide association studies, imputed using a merged reference panel of 1,000 Genomes and UK10K data, totalling 6,200 cases and 17,598 controls after replication. We identify nine risk loci at 1p36.11 (rs34676223, P = 5.04 X 10 (-) (13)), 1q42.13 (rs41271473, P = 1.06 X 10 (-) (10)), 4q24 (rs71597109, P = 1.37 X 10 (-) (10)), 4q35.1 (rs57214277, P = 3.69 X 10 (-) (8)), 6p21.31 (rs3800461, P = 1.97 X 10 (-) (8)), 11q23.2 (rs61904987, P = 2.64 X 10 (-) (11)), 18q21.1 (rs1036935, P = 3.27 X 10 (-) (8)), 19p13.3 (rs7254272, P = 4.67 X 10 (-) (8)) and 22q13.33 (rs140522, P = 2.70 X 10 (-) (9)). These new and established risk loci map to areas of active chromatin and show an over-representation of transcription factor binding for the key determinants of B-cell development and immune response.
Ämnesord
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)