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Cognitive function in very old men does not correlate to biomarkers of Alzheimer's disease

Velickaite, Vilma, (författare)
Uppsala universitet, Radiologi
Giedraitis, Vilmantas, (författare)
Uppsala universitet, Geriatrik, Molekylär geriatrik/ Rudbecklaboratoriet
Ström, K, (författare)
Uppsala universitet, Geriatrik
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Alafuzoff, Irina, (författare)
Uppsala universitet, Klinisk och experimentell patologi, Department of Pathology Uppsala University Hospital, Uppsala, Sweden., Irina Alufuzoff
Zetterberg, H, (författare)
Univ Gothenburg, Sahlgrenska Acad, Dept Psychiat & Neurochem, Molndal, Sweden.;Sahlgrens Univ Hosp, Clin Neurochem Lab, Molndal, Sweden.; UCL Inst Neurol, Dept Mol Neurosci, Queen Sq, London, England
Lannfelt, Lars, (författare)
Uppsala universitet, Geriatrik, Molekylär geriatrik/ Rudbecklaboratoriet
Kilander, Lena, (författare)
Uppsala universitet, Geriatrik
Larsson, Elna-Marie, (författare)
Uppsala universitet, Radiologi
Ingelsson, Martin, (författare)
Uppsala universitet, Geriatrik
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2017
Engelska.
Ingår i: BMC Geriatrics. - 1471-2318 .- 1471-2318. ; 17:1
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • <p><strong>BACKGROUND:</strong> The Alzheimer's disease (AD) brain displays atrophy with amyloid-β (Aβ) and tau deposition, whereas decreased Aβ42 and increased tau are measured in cerebrospinal fluid (CSF). The aim of this study was to relate cognitive performance to the degree of brain atrophy, CSF biomarker levels and neuropathology in a cohort of aged men.</p><p><strong>METHODS:</strong> Fifty-eight 86-92-year-old men from the Uppsala Longitudinal Study of Adult Men (ULSAM) cohort underwent cognitive testing, brain computed tomography and lumbar puncture. Atrophy was graded with established scales. Concentrations of CSF Aβ42, t-tau and p-tau were measured by ELISA. Thirteen brains were examined post mortem.</p><p><strong>RESULTS:</strong> Forty-six of the individuals were considered non-demented, whereas twelve were diagnosed with dementia, either at baseline (n = 4) or during follow-up (n = 8). When comparing subjects with and without dementia, there were no differences in the degree of atrophy, although the mini mental state examination (MMSE) scoring correlated weakly with the degree of medial temporal atrophy (MTA) (p = 0.04). Moreover, the CSF biomarker levels did not differ significantly between healthy (n = 27) and demented (n = 8) subjects (median values 715 vs 472 pg/ml for Aβ42, 414 vs 427 pg/ml for t-tau and 63 vs 60 pg/ml for p-tau). Similarly, there were no differences in the biomarker levels between individuals with mild (n = 24) and severe (n = 11) MTA (median values 643 vs 715 pg/ml for Aβ42, 441 vs 401 pg/ml for t-tau and 64 vs 53 pg/ml for p-tau). Finally, the neuropathological changes did not correlate with any of the other measures.</p><p><strong>CONCLUSION:</strong> In this cohort of aged men only a weak correlation could be seen between cognitive performance and MTA, whereas the various neuroradiological, biochemical and neuropathological measures did not correlate with each other. Thus, AD biomarkers seem to be less informative in subjects of an advanced age.</p>

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Neurologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Neurology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Geriatrik (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Geriatrics (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Klinisk laboratoriemedicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Clinical Laboratory Medicine (hsv//eng)

Nyckelord

AD biomarkers
Advanced age
Brain atrophy
CSF biomarkers
Cognitive performance
Neuropathology
Patologi
Pathology

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