Data Descriptor : Sequence data and association statistics from 12,940 type 2 diabetes cases and controls
Flannick, Jason (författare)
Massachusetts Gen Hosp, Dept Mol Biol, Boston, MA USA.;Broad Inst, Program Med & Populat Genet, Cambridge, MA USA.,Massachusetts General Hospital,Broad Institute
Fuchsberger, Christian (författare)
Univ Michigan, Dept Biostat, Ctr Stat Genet, Ann Arbor, MI USA.,University of Michigan
Mahajan, Anubha (författare)
Univ Oxford, Nuffield Dept Med, Wellcome Trust Ctr Human Genet, Oxford, England.,University of Oxford
Broad Inst, Program Med & Populat Genet, Cambridge, MA USA.
Kwan, Phoenix (författare)
Univ Michigan, Dept Biostat, Ctr Stat Genet, Ann Arbor, MI USA.
Grant, George (författare)
Broad Inst, Program Med & Populat Genet, Cambridge, MA USA.
Smith, Joshua D. (författare)
Univ Washington Sch Med, Dept Genome Sci, Seattle, WA USA.
Neale, Benjamin M. (författare)
Broad Inst, Program Med & Populat Genet, Cambridge, MA USA.;Massachusetts Gen Hosp, Dept Med, Analyt & Translat Genet Unit, Boston, MA USA.
Purcell, Shaun (författare)
Broad Inst, Program Med & Populat Genet, Cambridge, MA USA.;Massachusetts Gen Hosp, Dept Med, Ctr Genom Med, Boston, MA USA.;Icahn Inst Genom & Multiscale Biol, Icahn Sch Med Mt Sinai, Dept Psychiat, New York, NY USA.
Butterworth, Adam S. (författare)
Univ Cambridge, Dept Publ Hlth & Primary Care, Cambridge, England.
Howson, Joanna M. M. (författare)
Univ Cambridge, Dept Publ Hlth & Primary Care, Cambridge, England.
Lee, Heung Man (författare)
Chinese Univ Hong Kong, Dept Med & Therapeut, Hong Kong, Peoples R China.
Lu, Yingchang (författare)
Charles Bronfman Inst Personalized Med, Icahn Sch Med, Mt Sinai, New York, NY USA.
Kwak, Soo-Heon (författare)
Seoul Natl Univ Coll Med, Dept Internal Med, Seoul, South Korea.
Zhao, Wei (författare)
Univ Pennsylvania, Dept Med, Philadelphia, PA USA.
Danesh, John (författare)
Wellcome Trust Sanger Inst, Dept Human Genet, Hinxton, Cambridgeshire, England.;Univ Cambridge, Dept Publ Hlth & Primary Care, Cambridge, England.;Univ Cambridge, Dept Publ Hlth & Primary Care, NIHR Blood & Transplant Res Unit Donor Hlth & Gen, Cambridge, England.
Lam, Vincent K. L. (författare)
Chinese Univ Hong Kong, Dept Med & Therapeut, Hong Kong, Peoples R China.
Park, Kyong Soo (författare)
Seoul Natl Univ, Dept Mol Med & Biopharmaceut Sci, Grad Sch Convergence Sci & Technol, Seoul, South Korea.;Seoul Natl Univ, Coll Med, Seoul, South Korea.
Saleheen, Danish (författare)
Univ Pennsylvania, Dept Biostatist & Epidemiol, Philadelphia, PA USA.;Ctr Non Communicable Dis, Karachi, Pakistan.
So, Wing Yee (författare)
Chinese Univ Hong Kong, Dept Med & Therapeut, Hong Kong, Peoples R China.
Tam, Claudia H. T. (författare)
Chinese Univ Hong Kong, Dept Med & Therapeut, Hong Kong, Peoples R China.
Kings Coll London, Dept Twin Res & Genet Epidemiol, London, England.;Guys & St Thomas Fdn Trust, NIHR Biomed Res Ctr, London, England.
Bonnycastle, Lori L. (författare)
NIH, Natl Human Genome Res Inst, Med Genom & Metab Genet Branch, Bethesda, MD USA.
Schwarzmayr, Thomas (författare)
Helmholtz Zentrum Munchen, Inst Human Genet, German Res Ctr Environm Hlth, Neuherberg, Germany.
Fadista, Joao (författare)
Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups
Broad Inst, Program Med & Populat Genet, Cambridge, MA USA.;Univ Tartu, Estonian Genome Ctr, Tartu, Estonia.;Harvard Med Sch, Dept Genet, Boston, MA USA.;Boston Childrens Hosp, Divis Endocrinol, Boston, MA USA.
Farmer, Andrew J. (författare)
Univ Oxford, Nuffield Dept Primary Care Hlth Sci, Oxford, England.
Hakaste, Liisa (författare)
Univ Helsinki, Abdominal Ctr Endocrinol, Helsinki, Finland.;Helsinki Univ Cent Hosp, Abdominal Ctr Endocrinol, Helsinki, Finland.;Folkhalsan Res Ctr, Helsinki, Finland.;Univ Helsinki, Res Programs Unit, Diabet & Obes, Helsinki, Finland.
Lund University,Lunds universitet,Diabetiska komplikationer,Forskargrupper vid Lunds universitet,Diabetic Complications,Lund University Research Groups
Lyssenko, Valeriya (författare)
Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups
Hollensted, Mette (författare)
Univ Copenhagen, Fac Hlth & Med Sci, Novo Nordisk Fdn Ctr Basic Metab Res, Copenhagen, Denmark.
Jorgensen, Marit E. (författare)
Steno Diabet Ctr, Gentofte, Denmark.
Jorgensen, Torben (författare)
Capital Region Denmark, Res Ctr Prevent & Hlth, Glostrup, Denmark.;Univ Copenhagen, Inst Hlth Sci, Dept Publ Hlth, Copenhagen, Denmark.;Aalborg Univ, Fac Med, Aalborg, Denmark.
Ladenvall, Claes (författare)
Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups
Justesen, Johanne Marie (författare)
Univ Copenhagen, Fac Hlth & Med Sci, Novo Nordisk Fdn Ctr Basic Metab Res, Copenhagen, Denmark.
Karajamaki, Annemari (författare)
Vaasa Cent Hosp, Dept Primary Hlth Care, Vaasa, Finland.;Vaasa Hlth Care Ctr, Ctr Diabet, Vaasa, Finland.
Kriebel, Jennifer (författare)
German Ctr Diabet Res DZD, Munich, Germany.;Helmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Inst Epidemiol II, Neuherberg, Germany.;Helmholtz Zentrum Munchen, Res Unit Mol Epidemiol, German Res Ctr Environm Hlth, Neuherberg, Germany.
Rathmann, Wolfgang (författare)
German Ctr Diabet Res DZD, Munich, Germany.;Heinrich Heine Univ, German Diabet Ctr, Leibniz Ctr Diabet Res, Inst Biometr & Epidemiol, Dusseldorf, Germany.
Lannfelt, Lars (författare)
Uppsala universitet,Geriatrik
Lauritzen, Torsten (författare)
Aarhus Univ, Sect Gen Practice, Dept Publ Hlth, Aarhus, Denmark.
Narisu, Narisu (författare)
NIH, Natl Human Genome Res Inst, Med Genom & Metab Genet Branch, Bethesda, MD USA.
Linneberg, Allan (författare)
Capital Region Denmark, Res Ctr Prevent & Hlth, Glostrup, Denmark.;Dept Clin Expt Res, Rigshospitalet, Glostrup, Denmark.;Univ Copenhagen, Fac Hlth & Med Sci, Dept Clin Med, Copenhagen, Denmark.
Melander, Olle (författare)
Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Department of Clinical Sciences, Malmö,Faculty of Medicine,Cardiovascular Research - Hypertension,Lund University Research Groups
Lund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups
Qi, Lu (författare)
Harvard Sch Publ Hlth, Dept Nutr, Boston, MA USA.;Brigham & Womens Hosp & Harvard Med Sch, Channing Div Network Med, Dept Med, Boston, MA USA.
Qi, Qibin (författare)
Harvard Sch Publ Hlth, Dept Nutr, Boston, MA USA.;Albert Einstein Coll Med, Dept Epidemiol & Populat Hlth, New York, NY USA.
Roden, Michael (författare)
Heinrich Heine Univ, German Diabet Ctr, Leibniz Ctr Diabet Res, Inst Clin Diabetol, Dusseldorf, Germany.;German Ctr Diabet Res DZD, Munich, Germany.;Heinrich Heine Univ, Fac Med, Divis Endocrinol & Diabetol, Dusseldorf, Germany.
Univ Oxford, Nuffield Dept Med, Oxford Genom Ctr, Wellcome Trust Ctr Human Genet, Oxford, England.
Carneiro, Mauricio O. (författare)
Broad Inst, Program Med & Populat Genet, Cambridge, MA USA.
Maguire, Jared (författare)
Broad Inst, Program Med & Populat Genet, Cambridge, MA USA.
Poplin, Ryan (författare)
Broad Inst, Program Med & Populat Genet, Cambridge, MA USA.
Shakir, Khalid (författare)
Broad Inst, Program Med & Populat Genet, Cambridge, MA USA.
Fennell, Timothy (författare)
Broad Inst, Program Med & Populat Genet, Cambridge, MA USA.
DePristo, Mark (författare)
Broad Inst, Program Med & Populat Genet, Cambridge, MA USA.
De Angelis, Martin Hrabe (författare)
German Ctr Diabet Res DZD, Munich, Germany.;Helmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Inst Expt Genet, Neuherberg, Germany.;Tech Univ Munich, Ctr Life & Food Sci Weihenstephan, Freising Weihenstephan, Germany.
Deloukas, Panos (författare)
Wellcome Trust Sanger Inst, Dept Human Genet, Hinxton, Cambridgeshire, England.;Queen Mary Univ London, William Harvey Res Inst, London, England.;Queen Mary Univ London, London Sch Med & Dent, London, England.;King Abdulaziz Univ, Princess Jawhara Brahim Ctr Excellence Res Heredi, Jeddah, Saudi Arabia.
Gjesing, Anette P. (författare)
Univ Copenhagen, Fac Hlth & Med Sci, Novo Nordisk Fdn Ctr Basic Metab Res, Copenhagen, Denmark.
Jun, Goo (författare)
Univ Michigan, Dept Biostat, Ctr Stat Genet, Ann Arbor, MI USA.;Univ Texas Hlth Sci Ctr, Sch Publ Hlth, Ctr Human Genet, Houston, TX USA.
Harvard Sch Publ Hlth, Dept Biostatist, Boston, MA USA.;Harvard Sch Publ Hlth, Dept Epidemiol, Boston, MA USA.
Peters, Annette (författare)
DZHK German Ctr Cardiovascular Res, Munich Heart Alliance, Munich, Germany.;German Ctr Diabet Res DZD, Munich, Germany.;Helmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Inst Epidemiol II, Neuherberg, Germany.
Huth, Cornelia (författare)
German Ctr Diabet Res DZD, Munich, Germany.;Helmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Inst Epidemiol II, Neuherberg, Germany.
O'Rahilly, Stephen P. (författare)
Univ Cambridge, Inst Metab Sci, Metabol Res Labs, Cambridge, England.
Palmer, Colin N. A. (författare)
Ninewells Hosp & Med Sch, Pat Macpherson Ctr Pharmacogenet & Pharmacogenet, Dundee, Scotland.;Ninewells Hosp & Med Sch, Med Res Inst, Dundee, Scotland.
Pedersen, Oluf (författare)
Univ Copenhagen, Fac Hlth & Med Sci, Novo Nordisk Fdn Ctr Basic Metab Res, Copenhagen, Denmark.
Rauramaa, Rainer (författare)
Kuopio Res Inst Exercise Med, Foundat Res Hlth Exercise & Nutr, Kuopio, Finland.
Univ Southern Calif, Keck Sch Med, Dept Prevent Med, Los Angeles, CA USA.;Univ Southern Calif, Keck Sch Med, Dept Physiol Biophys, Los Angeles, CA USA.;Univ Southern Calif, Diabet & Obes Res Inst, Keck Sch Med, Los Angeles, CA USA.
Syvänen, Ann-Christine, 1950- (författare)
Uppsala universitet,Molekylär medicin,Science for Life Laboratory, SciLifeLab
Bergman, Richard N. (författare)
Cedars Sinai Diabet & Obes Res Inst, Los Angeles, CA USA.
Bharadwaj, Dwaipayan (författare)
CSIR Inst Genom Integrat Biol CSIR IGIB, Funct Genom Unit, New Delhi, India.
Bottinger, Erwin P. (författare)
Charles Bronfman Inst Personalized Med, Icahn Sch Med, Mt Sinai, New York, NY USA.
Cho, Yoon Shin (författare)
Hallym Univ, Dept Biomed Sci, Chunchon, South Korea.
Chandak, Giriraj R. (författare)
CSIR, Ctr Cellular & Mol Biol, Hyderabad, Andhra Pradesh, India.
Chan, Juliana Cn (författare)
Chinese Univ Hong Kong, Dept Med & Therapeut, Hong Kong, Peoples R China.;Chinese Univ Hong Kong, Li Ka Shing Inst Hlth Sci, Hong Kong, Peoples R China.;Chinese Univ Hong Kong, Hong Kong Inst Diabet & Obes, Hong Kong, Peoples R China.
Boston Univ Sch Publ Hlth, Dept Biostatist, Boston, MA USA.;Chinese Univ Hong Kong, Dept Med & Therapeut, Hong Kong, Peoples R China.;Chinese Univ Hong Kong, Li Ka Shing Inst Hlth Sci, Hong Kong, Peoples R China.;Chinese Univ Hong Kong, Hong Kong Inst Diabet & Obes, Hong Kong, Peoples R China.
Pollin, Toni I. (författare)
Univ Maryland Sch Med, Div Endocrinol Diabet & Nutr, Dept Med, Baltimore, MD USA.;Univ Maryland Sch Med, Program Personalized Genom Med, Baltimore, MD USA.
Sandhu, Manjinder (författare)
Wellcome Trust Sanger Inst, Dept Human Genet, Hinxton, Cambridgeshire, England.;Univ Cambridge, Dept Publ Hlth & Primary Care, Cambridge, England.
Tandon, Nikhil (författare)
All India Inst Med Sci, Dept Endocrinol & Metab, New Delhi, India.
Froguel, Philippe (författare)
Univ Lille, Lille Pasteur Inst, CNRS UMR8199, Lille, France.;Imperial Coll London, Sch Publ Hlth, Dept Genom Common Dis, London, England.
Barroso, Ines (författare)
Wellcome Trust Sanger Inst, Dept Human Genet, Hinxton, Cambridgeshire, England.;Univ Cambridge, Inst Metab Sci, Metabol Res Labs, Cambridge, England.
German Res Ctr Environm Hlth, Inst Genet Epidemiol, Helmholtz Zentrum Munchen, Neuherberg, Germany.
DeFronzo, Ralph A. (författare)
Univ Texas Hlth Sci Ctr, Dept Med, San Antonio, TX USA.
Grallert, Harald (författare)
German Ctr Diabet Res DZD, Munich, Germany.;Helmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Inst Epidemiol II, Neuherberg, Germany.;Helmholtz Zentrum Munchen, Res Unit Mol Epidemiol, German Res Ctr Environm Hlth, Neuherberg, Germany.
Broad Inst, Program Med & Populat Genet, Cambridge, MA USA.
Gieger, Christian (författare)
German Res Ctr Environm Hlth, Inst Genet Epidemiol, Helmholtz Zentrum Munchen, Neuherberg, Germany.;Helmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Inst Epidemiol II, Neuherberg, Germany.;Helmholtz Zentrum Munchen, Res Unit Mol Epidemiol, German Res Ctr Environm Hlth, Neuherberg, Germany.
Ingelsson, Erik, 1975- (författare)
Uppsala universitet,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab,Univ Oxford, Nuffield Dept Med, Wellcome Trust Ctr Human Genet, Oxford, England
Im, Hae Kyung (författare)
Univ Chicago, Med Genet Sect, Dept Med, Chicago, IL USA.
Illig, Thomas (författare)
Helmholtz Zentrum Munchen, Res Unit Mol Epidemiol, German Res Ctr Environm Hlth, Neuherberg, Germany.;Hannover Med Sch, Hannover Unified Biobank, Hannover, NH, Germany.;Hannover Med Sch, Dept Human Genet, Hannover, NH, Germany.
Broad Inst, Program Med & Populat Genet, Cambridge, MA USA.
Mohlke, Karen L. (författare)
Univ N Carolina, Dept Genet, Chapel Hill, NC USA.
Meitinger, Thomas (författare)
Helmholtz Zentrum Munchen, Inst Human Genet, German Res Ctr Environm Hlth, Neuherberg, Germany.;Tech Univ Munich, Inst Human Genet, Munich, Germany.
Groop, Leif (författare)
Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups,University of Helsinki
Abecasis, Goncalo (författare)
Univ Michigan, Dept Biostat, Ctr Stat Genet, Ann Arbor, MI USA.
Scott, Laura J. (författare)
Univ Michigan, Dept Biostat, Ctr Stat Genet, Ann Arbor, MI USA.
Massachusetts Gen Hosp, Dept Mol Biol, Boston, MA USA.
Altshuler, David (författare)
Massachusetts Gen Hosp, Dept Mol Biol, Boston, MA USA.;Broad Inst, Program Med & Populat Genet, Cambridge, MA USA.;Harvard Med Sch, Dept Genet, Boston, MA USA.;Harvard Med Sch, Dept Med, Boston, MA USA.;Massachusetts Gen Hosp, Dept Med, Diabet Res Ctr Diabet Unit, Boston, MA USA.;MIT, Dept Biol, Cambridge, MA 02139 USA.
Burtt, Noel P. (författare)
Broad Inst, Program Med & Populat Genet, Cambridge, MA USA.
Florez, Jose C. (författare)
Broad Inst, Program Med & Populat Genet, Cambridge, MA USA.;Massachusetts Gen Hosp, Dept Med, Ctr Genom Med, Boston, MA USA.;Harvard Med Sch, Dept Med, Boston, MA USA.;Massachusetts Gen Hosp, Dept Med, Diabet Res Ctr Diabet Unit, Boston, MA USA.
Boehnke, Michael (författare)
Univ Michigan, Dept Biostat, Ctr Stat Genet, Ann Arbor, MI USA.
Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups
Franks, Paul (författare)
Umeå University,Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups,Harvard University
V Varga, Tibor (författare)
Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups
Rosengren, Anders (författare)
Lund University,Lunds universitet,Diabetes - öpatofysiologi,Forskargrupper vid Lunds universitet,Diabetes - Islet Patophysiology,Lund University Research Groups
Massachusetts Gen Hosp, Dept Mol Biol, Boston, MA USA;Broad Inst, Program Med & Populat Genet, Cambridge, MA USA. Massachusetts General Hospital (creator_code:org_t)
To investigate the genetic basis of type 2 diabetes (T2D) to high resolution, the GoT2D and T2D-GENES consortia catalogued variation from whole-genome sequencing of 2,657 European individuals and exome sequencing of 12,940 individuals of multiple ancestries. Over 27M SNPs, indels, and structural variants were identified, including 99% of low-frequency (minor allele frequency [MAF] 0.1-5%) non-coding variants in the whole-genome sequenced individuals and 99.7% of low-frequency coding variants in the whole-exome sequenced individuals. Each variant was tested for association with T2D in the sequenced individuals, and, to increase power, most were tested in larger numbers of individuals (> 80% of low-frequency coding variants in similar to ~82 K Europeans via the exome chip, and similar to ~90% of low-frequency non-coding variants in similar to ~44 K Europeans via genotype imputation). The variants, genotypes, and association statistics from these analyses provide the largest reference to date of human genetic information relevant to T2D, for use in activities such as T2D-focused genotype imputation, functional characterization of variants or genes, and other novel analyses to detect associations between sequence variation and T2D.
Ämnesord
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper (hsv//swe)
MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Basic Medicine (hsv//eng)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)