Univ Hosp Munich, Inst & Outpatient Clin Occupat Social & En, Munich, Germany.;Helmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Inst Epidemiol 1, Neuherberg, Germany.
Heliovaara, Markku (författare)
Natl Inst Hlth & Welf THL, Helsinki, Finland.
Henderson, John (författare)
Univ Bristol, Bristol Med Sch, Populat Hlth Sci, Bristol, Avon, England.;Univ Bristol, MRC Integrat Epidemiol Unit, Bristol, Avon, England.
Himes, Blanca E. (författare)
Univ Penn, Dept Biostat Epidemiol & Informat, Philadelphia, PA 19104 USA.
Hirose, Hiroshi (författare)
Keio Univ, Dept Internal Med, Hlth Ctr, Tokyo, Japan.
Hirschhorn, Joel N. (författare)
Broad Inst, Cambridge, MA USA.;Boston Childrens Hosp, Div Endocrinol, Boston, MA USA.;Boston Childrens Hosp, Ctr Basic & Translat Obes Res, Boston, MA USA.;Harvard Med Sch, Dept Pediat, Boston, MA USA.;Harvard Med Sch, Dept Genet, Boston, MA USA.
Hofman, Albert (författare)
Univ Med Ctr Rotterdam, Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands.;Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA.
Ontario Inst Canc Res, Toronto, ON, Canada.;AbbVie Inc, Redwood City, CA USA.
Hui, Jennie (författare)
Queen Elizabeth II Med Ctr, Dept Diagnost Genom Lab, PathWest Lab Med, Nedlands, WA, Australia.;Busselton Populat Med Res Inst, Perth, WA, Australia.;Univ Western Australia, Sch Populat & Global Hlth, Nedlands, WA, Australia.
Kursk State Med Univ, Dept Biol Med Genet & Ecol, Kursk, Russia.
Jaddoe, Vincent W. V. (författare)
Univ Med Ctr Rotterdam, Erasmus MC, Generat R Study Grp, Dept Pediat, Rotterdam, Netherlands.;Univ Med Ctr Rotterdam, Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands.
James, Alan (författare)
Sir Charles Gairdner Hosp, Dept Pulm Physiol & Sleep Med, Busselton Populat Med Res Inst, Nedlands, WA, Australia.;Univ Western Australia, Sch Med & Pharmacol, Crawley, WA, Australia.
Janson, Christer (författare)
Uppsala universitet,Lung- allergi- och sömnforskning
Jarvelin, Marjo-Riitta (författare)
Imperial Coll London, Dept Epidemiol & Biostat, MRC PHE Ctr Environm & Hlth, Sch Publ Hlth, London, England.;Univ Oulu, Fac Med, Ctr Life Course Hlth Res, Oulu, Finland.;Univ Oulu, Bioctr Oulu, Oulu, Finland.;Oulu Univ Hosp, Unit Primary Care, Oulu, Finland.
RIKEN Ctr Integrat Med Sci, Yokohama, Kanagawa, Japan.
Kumar, Rajesh (författare)
Ann & Robert H Lurie Childrens Hosp Chicago, Chicago, IL 60611 USA.;Northwestern Univ, Dept Pediat, Div Allergy & Clin Immunol, Feinberg Sch Med, Chicago, IL 60611 USA.
INSERM, UMR 946, Genet Variat & Human Dis Unit, Paris, France.;Univ Paris Diderot, Univ Sorbonne Paris Cite, Inst Univ Hematol, Paris, France.
Musk, Arthur W. (författare)
Sir Charles Gairdner Hosp, Dept Resp Med, Nedlands, WA, Australia.;Univ Western Australia, Sch Populat Hlth, Perth, WA, Australia.;Univ Western Australia, Sch Med & Pharmacol, Perth, WA, Australia.
Myers, Rachel A. (författare)
Duke Univ, Sch Med, Ctr Appl Genom & Precis Med, Durham, NC USA.
Nieuwenhuis, Maartje A. E. (författare)
Groningen Res Inst Asthma & COPD GRIAC, Groningen, Netherlands.;Univ Groningen, Dept Pulmonol, Univ Med Ctr Groningen, Groningen, Netherlands.
Noguchi, Emiko (författare)
Univ Tsukuba, Fac Med, Dept Med Genet, Tsukuba, Ibaraki, Japan.
O'Connor, George T. (författare)
Boston Univ, Sch Med, Dept Med, Pulmonary Ctr, Boston, MA 02118 USA.;Natl Heart Lung & Blood Inst Framingham Heart Stu, Framingham, MA USA.
Ogorodova, Ludmila M. (författare)
Siberian State Med Univ, Dept Fac Pediat, Tomsk, Russia.
Palmer, Cameron D. (författare)
Broad Inst, Cambridge, MA USA.;Boston Childrens Hosp, Div Endocrinol, Boston, MA USA.;Boston Childrens Hosp, Ctr Basic & Translat Obes Res, Boston, MA USA.
Palotie, Aarno (författare)
Univ Helsinki, Inst Mol Med Finland FIMM, Helsinki, Finland.;Massachusetts Gen Hosp, Analyt & Translat Genet Unit, Dept Med, Boston, MA 02114 USA.;Massachusetts Gen Hosp, Analyt & Translat Genet Unit, Dept Neurol, Boston, MA 02114 USA.;Massachusetts Gen Hosp, Analyt & Translat Genet Unit, Dept Psychiat, Boston, MA 02114 USA.;Broad Inst, Stanley Ctr Psychiat Res & Program Med & Populat, Cambridge, MA USA.
Park, Julie E. (författare)
Univ British Columbia, Dept Med, Vancouver, BC, Canada.
Helmholtz Zentrum Munchen, German Res Ctr Environm Hlth, Inst Epidemiol 1, Neuherberg, Germany.;Ludwig Maximilians Univ Munchen, Dr von Hauner Childrens Hosp, Div Metab Dis & Nutrit Med, Munich, Germany.
Torgerson, Dara G. (författare)
Univ Calif San Francisco, Dept Med, San Francisco, CA USA.
Tsunoda, Tatsuhiko (författare)
RIKEN Ctr Integrat Med Sci, Yokohama, Kanagawa, Japan.;Tokyo Med & Dent Univ, Dept Med Sci Math, Med Res Inst, Tokyo, Japan.
Natl Heart & Lung Inst, Sect Genom Med, London, England.
Ober, Carole (författare)
Univ Chicago, Dept Human Genet, Chicago, IL 60637 USA.
Nicolae, Dan L. (författare)
Univ Chicago, Dept Stat, Med Genet Sect, Chicago, IL 60637 USA.;Univ Chicago, Dept Human Genet, Med Genet Sect, Chicago, IL 60637 USA.;Univ Chicago, Dept Med, Med Genet Sect, Chicago, IL 60637 USA.
INSERM, UMR 946, Genet Variat & Human Dis Unit, Paris, France;Univ Paris Diderot, Univ Sorbonne Paris Cite, Inst Univ Hematol, Paris, France. Univ Colorado, Colorado Ctr Personalized Med, Div Biomed Informat & Personalized Med, Denver, CO 80202 USA. (creator_code:org_t)
2018
2018
Engelska.
Ingår i: Nature Genetics. - 1061-4036 .- 1546-1718. ; 50:1, s. 42-
We examined common variation in asthma risk by conducting a meta-analysis of worldwide asthma genome-wide association studies (23,948 asthma cases, 118,538 controls) of individuals from ethnically diverse populations. We identified five new asthma loci, found two new associations at two known asthma loci, established asthma associations at two loci previously implicated in the comorbidity of asthma plus hay fever, and confirmed nine known loci. Investigation of pleiotropy showed large overlaps in genetic variants with autoimmune and inflammatory diseases. The enrichment in enhancer marks at asthma risk loci, especially in immune cells, suggested a major role of these loci in the regulation of immunologically related mechanisms.