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Sökning: onr:"swepub:oai:DiVA.org:uu-348318" > Evolution of neurop...

Evolution of neuropeptide signalling systems

Elphick, Maurice R. (författare)
Queen Mary Univ London, Sch Biol & Chem Sci, London E1 4NS, England.
Mirabeau, Olivier (författare)
Paris Sci & Lettres Res Univ, INSERM U830, Inst Curie, Genet & Biol Canc Unit, F-75005 Paris, France.
Larhammar, Dan, 1956- (författare)
Uppsala universitet,Farmakologi,Science for Life Laboratory, SciLifeLab
Queen Mary Univ London, Sch Biol & Chem Sci, London E1 4NS, England Paris Sci & Lettres Res Univ, INSERM U830, Inst Curie, Genet & Biol Canc Unit, F-75005 Paris, France. (creator_code:org_t)
COMPANY OF BIOLOGISTS LTD, 2018
2018
Engelska.
Ingår i: ; 221:3
  • Forskningsöversikt (refereegranskat)
Abstract Ämnesord
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  • Neuropeptides are a diverse class of neuronal signalling molecules that regulate physiological processes and behaviour in animals. However, determining the relationships and evolutionary origins of the heterogeneous assemblage of neuropeptides identified in a range of phyla has presented a huge challenge for comparative physiologists. Here, we review revolutionary insights into the evolution of neuropeptide signalling that have been obtained recently through comparative analysis of genome/transcriptome sequence data and by 'deorphanisation' of neuropeptide receptors. The evolutionary origins of at least 30 neuropeptide signalling systems have been traced to the common ancestor of protostomes and deuterostomes. Furthermore, two rounds of genome duplication gave rise to an expanded repertoire of neuropeptide signalling systems in the vertebrate lineage, enabling neofunctionalisation and/or subfunctionalisation, but with lineage-specific gene loss and/or additional gene or genome duplications generating complex patterns in the phylogenetic distribution of paralogous neuropeptide signalling systems. We are entering a new era in neuropeptide research where it has become feasible to compare the physiological roles of orthologous and paralogous neuropeptides in a wide range of phyla. Moreover, the ambitious mission to reconstruct the evolution of neuropeptide function in the animal kingdom now represents a tangible challenge for the future.

Ämnesord

NATURAL SCIENCES  -- Biological Sciences -- Evolutionary Biology (hsv//eng)
NATURVETENSKAP  -- Biologiska vetenskaper -- Evolutionsbiologi (hsv//swe)
NATURVETENSKAP  -- Biologi (hsv//swe)
NATURAL SCIENCES  -- Biological Sciences (hsv//eng)

Nyckelord

Evolution
Invertebrate
Neuropeptide
Phylogeny
Receptor
Vertebrate

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Elphick, Maurice ...
Mirabeau, Olivie ...
Larhammar, Dan, ...
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NATURVETENSKAP
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och Biologiska veten ...
och Evolutionsbiolog ...
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och Biologi
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Journal of Exper ...
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Uppsala universitet

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