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Sökning: onr:"swepub:oai:DiVA.org:uu-360434" > Risk of Fractures i...

Risk of Fractures in Youths with Celiac Disease-A Population-Based Study

Canova, Cristina, (författare)
Department of Cardiological, Thoracic and Vascular Sciences, University of Padua, Padua, Italy
Pitter, Gisella, (författare)
Department of Cardiological, Thoracic and Vascular Sciences, University of Padua, Padua, Italy
Zanier, Loris, (författare)
Epidemiological Service, Health Directorate, Friuli Venezia-Giulia Region, Udine, Italy
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Simonato, Lorenzo, (författare)
Department of Cardiological, Thoracic and Vascular Sciences, University of Padua, Padua, Italy
Michaelsson, Karl, (författare)
Department of Surgical Sciences, Uppsala University, Uppsala, Sweden
Ludvigsson, Jonas F., 1969- (författare)
Örebro universitet, Institutionen för medicinska vetenskaper, Region Örebro län, Department Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; Department of Pediatrics, Örebro University Hospital, Örebro University, Örebro, Sweden; Division of Epidemiology and Public Health, School of Medicine, University of Nottingham, Nottingham, United Kingdom; Department of Medicine, Columbia University College of Physicians and Surgeons, New York NY, USA
Michaëlsson, Karl, 1959- (författare)
Uppsala universitet, Ortopedi
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Örebro universitet Institutionen för medicinska vetenskaper. (creator_code:org_t)
Region Örebro län (creator_code:org_t)
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Uppsala universitet Medicinska och farmaceutiska vetenskapsområdet. Medicinska fakulteten. Institutionen för kirurgiska vetenskaper. Ortopedi. (creator_code:org_t)
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2018
Engelska.
Ingår i: Journal of Pediatric Surgery Case Reports. - MOSBY-ELSEVIER. - 0022-3476 .- 2213-5766. ; 198, s. 117-120
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • Objective To assess the risk of any fracture requiring hospital care in a cohort of individuals with celiac disease diagnosed in childhood/adolescence compared with reference individuals matched by age and sex. Study design Our study cohort consisted of 213 635 people born and residing in Friuli-Venezia Giulia Region, Italy, in 1989-2011. We selected, through pathology reports, hospital discharge records, or co-payment exemptions, 1233 individuals with celiac disease (aged 0-17 years at diagnosis) and compared them with 6167 reference individuals matched by sex and year of birth. Fractures were identified through hospital discharge records. We calculated hazard ratios (HRs) for any fracture after celiac disease diagnosis (or index date for reference individuals) with Cox regression and ORs for any fracture before celiac disease diagnosis with conditional logistic regression. Results During the follow-up period (maximum 23 years), 22 individuals with celiac disease (9394 person-years) and 128 reference individuals (47 308 person-years) experienced a fracture. giving an overall HR of 0.87 (95% CI 0.55-1.37). The risk was not modified by sex, age at diagnosis, or calendar period of diagnosis. We obtained similar HRs when excluding fractures occurring after the age of 18 years and adjusting for maternal education or vitamin D supplementation. The odds of previous fracture also did not differ between subjects with celiac disease and reference individuals (22 and 96 cases, respectively: OR 1.15: 95% CI 0.72-1.84). Conclusions We did not find any evidence of an increased risk of fractures during childhood and youth among patients with celiac disease.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Pediatrik (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Pediatrics (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Hälsovetenskaper -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)

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