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Sökning: onr:"swepub:oai:DiVA.org:uu-363208" > Advanced parental a...

  • Petridou, Eleni Th.Karolinska Inst, Dept Med, Clin Epidemiol Unit, Stockholm, Sweden;Univ Athens, Med Sch, Dept Hyg Epidemiol & Med Stat, 75 Mikras Asias Str, Athens 11527, Greece (författare)

Advanced parental age as risk factor for childhood acute lymphoblastic leukemia : results from studies of the Childhood Leukemia International Consortium

  • Artikel/kapitelEngelska2018

Förlag, utgivningsår, omfång ...

  • SPRINGER,2018
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:uu-363208
  • urn:nbn:se:uu:diva-363208urn
  • https://doi.org/10.1007/s10654-018-0402-zDOI

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  • Språk:engelska
  • Sammanfattning på:engelska

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  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Advanced parental age has been associated with adverse health effects in the offspring including childhood (0-14 years) acute lymphoblastic leukemia (ALL), as reported in our meta-analysis of published studies. We aimed to further explore the association using primary data from 16 studies participating in the Childhood Leukemia International Consortium. Data were contributed by 11 case-control (CC) studies (7919 cases and 12,942 controls recruited via interviews) and five nested case-control (NCC) studies (8801 cases and 29,690 controls identified through record linkage of population-based health registries) with variable enrollment periods (1968-2015). Five-year paternal and maternal age increments were introduced in two meta-analyses by study design using adjusted odds ratios (OR) derived from each study. Increased paternal age was associated with greater ALL risk in the offspring (ORCC 1.05, 95% CI 1.00-1.11; ORNCC 1.04, 95% CI 1.01-1.07). A similar positive association with advanced maternal age was observed only in the NCC results (ORCC 0.99, 95% CI 0.91-1.07, heterogeneity I (2) = 58%, p = 0.002; ORNCC 1.05, 95% CI 1.01-1.08). The positive association between parental age and risk of ALL was most marked among children aged 1-5 years and remained unchanged following mutual adjustment for the collinear effect of the paternal and maternal age variables; analyses of the relatively small numbers of discordant paternal-maternal age pairs were not fully enlightening. Our results strengthen the evidence that advanced parental age is associated with increased childhood ALL risk; collinearity of maternal with paternal age complicates causal interpretation. Employing datasets with cytogenetic information may further elucidate involvement of each parental component and clarify underlying mechanisms.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Georgakis, Marios K.Univ Athens, Med Sch, Dept Hyg Epidemiol & Med Stat, 75 Mikras Asias Str, Athens 11527, Greece (författare)
  • Erdmann, FriederikeDanish Canc Soc Res Ctr, Childhood Canc Survivorship Res Grp, Unit Survivorship, Copenhagen, Denmark;Int Agcy Res Canc, Sect Environm & Radiat, Lyon, France (författare)
  • Ma, XiaomeiYale Sch Med, Yale Comprehens Canc Ctr, Yale Sch Publ Hlth Canc Prevent & Control, Dept Chron Dis Epidemiol, New Haven, CT USA (författare)
  • Heck, Julia E.Univ Calif Los Angeles, Sch Publ Hlth, Dept Epidemiol, Los Angeles, CA 90024 USA (författare)
  • Auvinen, AnssiUniv Tampere, Fac Social Sci, Tampere, Finland (författare)
  • Mueller, Beth A.Univ Washington, Sch Publ Hlth, Dept Epidemiol, Seattle, WA 98195 USA;Fred Hutchinson Canc Res Ctr, Publ Hlth Sci Div, Seattle, WA USA (författare)
  • Spector, Logan G.Univ Minnesota, Dept Pediat, Div Epidemiol & Clin Res, Minneapolis, MN 55455 USA (författare)
  • Roman, EveUniv York, Dept Hlth Sci, Epidemiol & Canc Stat Grp, York, N Yorkshire, England (författare)
  • Metayer, CatherineUniv Calif Berkeley, Sch Publ Hlth, Berkeley, CA 94720 USA (författare)
  • Magnani, CorradoUniv Piemonte Orientale, SCDU Epidemiol Tumori, Dipartimento Med Traslazi, Novara, Italy (författare)
  • Pombo-de-Oliveira, Maria S.Inst Nacl Canc, Pediat Hematol Oncol Program, Rio De Janeiro, Brazil (författare)
  • Ezzat, SameeraMenoufia Univ, Natl Liver Inst, NLI SSI Collaborat Res Ctr, Dept Epidemiol & Prevent Med, Cairo, Egypt (författare)
  • Scheurer, Michael E.Baylor Coll Med, Texas Childrens Canc Ctr, Dept Pediat, Houston, TX 77030 USA (författare)
  • Maria Mora, AnaUniv Nacl, Cent Amer Inst Studies Toxic Subst IRET, Heredia, Costa Rica (författare)
  • Dockerty, John D.Univ Otago, Dunedin Sch Med, Dept Preventat & Social Med, Dunedin, New Zealand (författare)
  • Hansen, JohnniDanish Canc Soc, Res Ctr, Copenhagen, Denmark (författare)
  • Kang, Alice Y.Univ Calif Berkeley, Sch Publ Hlth, Berkeley, CA 94720 USA (författare)
  • Wang, RongYale Sch Med, Yale Comprehens Canc Ctr, Yale Sch Publ Hlth Canc Prevent & Control, Dept Chron Dis Epidemiol, New Haven, CT USA (författare)
  • Doody, David R.Fred Hutchinson Canc Res Ctr, Publ Hlth Sci Div, Seattle, WA USA (författare)
  • Kane, EleanorUniv York, Dept Hlth Sci, Epidemiol & Canc Stat Grp, York, N Yorkshire, England (författare)
  • Rashed, Waffa M.Childrens Canc Hosp Egypt, Res Dept, Cairo, Egypt;Armed Forces Coll Med, Biomed Res Dept, Cairo, Egypt (författare)
  • Dessypris, NickUniv Athens, Med Sch, Dept Hyg Epidemiol & Med Stat, 75 Mikras Asias Str, Athens 11527, Greece (författare)
  • Schuz, JoachimInt Agcy Res Canc, Sect Environm & Radiat, Lyon, France (författare)
  • Infante-Rivard, ClaireMcGill Univ, Fac Med, Dept Epidemiol Biostat & Occupat Hlth, Montreal, PQ, Canada (författare)
  • Skalkidou, Alkistis,1977-Uppsala universitet,Obstetrisk och reproduktiv hälsoforskning(Swepub:uu)alksk607 (författare)
  • Karolinska Inst, Dept Med, Clin Epidemiol Unit, Stockholm, Sweden;Univ Athens, Med Sch, Dept Hyg Epidemiol & Med Stat, 75 Mikras Asias Str, Athens 11527, GreeceUniv Athens, Med Sch, Dept Hyg Epidemiol & Med Stat, 75 Mikras Asias Str, Athens 11527, Greece (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:European Journal of Epidemiology: SPRINGER33:10, s. 965-9760393-29901573-7284

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