Mayo Clin, Dept Hlth Sci Res, Rochester, MN 55905 USA
Li, Shengchao Alfred (författare)
Leidos Biomed Res Inc, Frederick Natl Lab Canc Res, Canc Genom Res Lab, Frederick, MD 20877 USA
Vajdic, Claire M. (författare)
Univ New South Wales, Ctr Big Data Res Hlth, Sydney, NSW 2052, Australia
Smedby, Karin E. (författare)
Solna Karolinska Inst, Dept Med, S-17176 Stockholm, Sweden;Karolinska Univ Hosp, Hematol Ctr, S-17176 Stockholm, Sweden
Yan, Huihuang (författare)
Mayo Clin, Dept Hlth Sci Res, Rochester, MN 55905 USA
Birmann, Brenda M. (författare)
Brigham & Womens Hosp, Dept Med, Channing Div Network Med, Boston, MA 02115 USA;Harvard Med Sch, Boston, MA 02115 USA
Brown, Elizabeth E. (författare)
Univ Alabama Birmingham, Dept Pathol, Birmingham, AL 35233 USA
Smith, Alex (författare)
Univ York, Dept Hlth Sci, York YO10 5DD, N Yorkshire, England
Kleinstern, Geffen (författare)
Mayo Clin, Dept Hlth Sci Res, Rochester, MN 55905 USA
Fansler, Mervin M. (författare)
Weill Cornell Grad Coll, Triinst Training Program Computat Biol & Med, New York, NY 10021 USA;Mem Sloan Kettering Canc Ctr, Canc Biol & Genet Program, New York, NY 10065 USA
Mayr, Christine (författare)
Mem Sloan Kettering Canc Ctr, Canc Biol & Genet Program, New York, NY 10065 USA
Zhu, Bin (författare)
Leidos Biomed Res Inc, Frederick Natl Lab Canc Res, Canc Genom Res Lab, Frederick, MD 20877 USA
Chung, Charles C. (författare)
Leidos Biomed Res Inc, Frederick Natl Lab Canc Res, Canc Genom Res Lab, Frederick, MD 20877 USA
Park, Ju-Hyun (författare)
Dongguk Univ, Dept Stat, Seoul 100715, South Korea
Burdette, Laurie (författare)
Leidos Biomed Res Inc, Frederick Natl Lab Canc Res, Canc Genom Res Lab, Frederick, MD 20877 USA
Hicks, Belynda D. (författare)
Leidos Biomed Res Inc, Frederick Natl Lab Canc Res, Canc Genom Res Lab, Frederick, MD 20877 USA
Hutchinson, Amy (författare)
Leidos Biomed Res Inc, Frederick Natl Lab Canc Res, Canc Genom Res Lab, Frederick, MD 20877 USA
Teras, Lauren R. (författare)
Amer Canc Soc, Epidemiol Res Program, Atlanta, GA 30303 USA
Adami, Hans-Olov (författare)
Karolinska Inst, Dept Med Epidemiol & Biostat, S-17177 Stockholm, Sweden;Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA;Univ Oslo, Inst Hlth & Soc, Clin Effectiveness Res Grp, NO-0316 Oslo, Norway
Bracci, Paige M. (författare)
Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA 94118 USA
McKay, James (författare)
IARC, F-69372 Lyon, France
Monnereau, Alain (författare)
INSERM, Ctr Res Epidemiol & Stat Sorbonne Paris Cit CRESS, Epidemiol Childhood & Adolescent Canc Grp, F-94807 Paris, France;Univ Paris 05, F-75006 Paris, France;Univ Bordeaux, Inst Bergonie, Registry Hematol Malignancies Gironde, Team EPICENE,Inserm,UMR 1219, F-33000 Bordeaux, France
Link, Brian K. (författare)
Univ Iowa, Carver Coll Med, Dept Internal Med, Iowa City, IA 52242 USA
Vermeulen, Roel C. H. (författare)
Univ Utrecht, Inst Risk Assessment Sci, NL-3508 TD Utrecht, Netherlands;Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, NL-3584 CX Utrecht, Netherlands
Ansell, Stephen M. (författare)
Mayo Clin, Dept Internal Med, Rochester, MN 55905 USA
Maria, Ann (författare)
Mem Sloan Kettering Canc Ctr, Dept Med, New York, NY 10065 USA
Diver, W. Ryan (författare)
Amer Canc Soc, Epidemiol Res Program, Atlanta, GA 30303 USA
Melbye, Mads (författare)
Statens Serum Inst, Dept Epidemiol Res, Div Hlth Surveillance & Res, DK-2300 Copenhagen, Denmark;Stanford Univ, Dept Med, Sch Med, Stanford, CA 94305 USA
Ojesina, Akinyemi, I (författare)
Univ Alabama Birmingham, Sch Publ Hlth, Dept Epidemiol, Birmingham, AL 35233 USA;Univ Alabama Birmingham, Comprehens Canc Ctr, Birmingham, AL 35233 USA
Kraft, Peter (författare)
Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA;Harvard TH Chan Sch Publ Hlth, Dept Biostat, Boston, MA 02115 USA
Boffetta, Paolo (författare)
Icahn Sch Med Mt Sinai, Tisch Canc Inst, New York, NY 10029 USA
Clavel, Jacqueline (författare)
INSERM, Ctr Res Epidemiol & Stat Sorbonne Paris Cit CRESS, Epidemiol Childhood & Adolescent Canc Grp, F-94807 Paris, France;Univ Paris 05, F-75006 Paris, France
Giovannucci, Edward (författare)
Brigham & Womens Hosp, Dept Med, Channing Div Network Med, Boston, MA 02115 USA;Harvard Med Sch, Boston, MA 02115 USA;Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA;Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA
Besson, Caroline M. (författare)
Inserm U1018, Ctr Rech Epidmiol St Populat CESP, Serv Hematol & Oncol, Ctr Hosp Versailles, F-78157 Villejuif, France
Canzia, Federico (författare)
German Canc Res Ctr, Genom Epidemiol Grp, D-69120 Heidelberg, Germany
Travis, Ruth C. (författare)
Univ Oxford, Canc Epidemiol Unit, Oxford OX3 7LF, England
Waldenstrom macroglobulinemia (WM)/lymphoplasmacytic lymphoma (LPL) is a rare, chronic B-cell lymphoma with high heritability. We conduct a two-stage genome-wide association study of WM/LPL in 530 unrelated cases and 4362 controls of European ancestry and identify two high-risk loci associated with WM/LPL at 6p25.3 (rs116446171, near EXOC2 and IRF4; OR = 21.14, 95% CI: 14.40-31.03, P=1.36 x 10(-)(54)) and 14q32.13 (rs117410836, near TCL1; OR = 4.90, 95% CI: 3.45-6.96, P = 8.75 x 10(-)(19)) . Both risk alleles are observed at a low frequency among controls (similar to 2-3%) and occur in excess in affected cases within families. In silico data suggest that rs116446171 may have functional importance, and in functional studies, we demonstrate increased reporter transcription and proliferation in cells transduced with the 6p25.3 risk allele. Although further studies are needed to fully elucidate underlying biological mechanisms, together these loci explain 4% of the familial risk and provide insights into genetic susceptibility to this malignancy.
Ämnesord
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)