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Association of maternal prenatal smoking GFI1-locus and cardiometabolic phenotypes in 18,212 adults

Parmar, Priyanka, (författare)
Univ Oulu, Ctr Life Course Hlth Res, Oulu, Finland;Univ Oulu, Bioctr Oulu, Oulu, Finland
Lowry, Estelle, (författare)
Univ Oulu, Ctr Life Course Hlth Res, Oulu, Finland;Univ Oulu, Bioctr Oulu, Oulu, Finland
Cugliari, Giovanni, (författare)
Univ Turin, Dept Med Sci, Turin, Italy;IIGM, Turin, Italy
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Suderman, Matthew, (författare)
Univ Bristol, Bristol Med Sch, MRC Integrat Epidemiol Unit, Populat Hlth Sci, Bristol, Avon, England
Wilson, Rory, (författare)
Helmholtz Zentrum Munchen, Res Unit Mol Epidemiol, German Res Ctr Environm Hlth, Neuherberg, Bavaria, Germany;Helmholtz Zentrum Munchen, Inst Epidemiol, German Res Ctr Environm Hlth, Neuherberg, Bavaria, Germany
Karhunen, Ville, (författare)
Imperial Coll London, MRC PHE Ctr Environm & Hlth, Sch Publ Hlth, Dept Epidemiol & Biostat, London, England
Andrew, Toby, (författare)
Imperial Coll London, Dept Med, Genom Common Dis, London, England
Wiklund, Petri, (författare)
Univ Oulu, Ctr Life Course Hlth Res, Oulu, Finland;Imperial Coll London, MRC PHE Ctr Environm & Hlth, Sch Publ Hlth, Dept Epidemiol & Biostat, London, England;Univ Jyvaskyla, Dept Hlth Sci, Jyvaskyla, Finland
Wielscher, Matthias, (författare)
Imperial Coll London, MRC PHE Ctr Environm & Hlth, Sch Publ Hlth, Dept Epidemiol & Biostat, London, England
Guarrera, Simonetta, (författare)
Univ Turin, Dept Med Sci, Turin, Italy;IIGM, Turin, Italy
Teumer, Alexander, (författare)
Univ Med Greifswald, Dept Internal Med B, Greifswald, Germany
Lehne, Benjamin, (författare)
Imperial Coll London, MRC PHE Ctr Environm & Hlth, Sch Publ Hlth, Dept Epidemiol & Biostat, London, England
Milani, Lili, 1981- (författare)
Uppsala universitet, Molekylär medicin, Univ Tartu, Estonian Genome Ctr, Inst Genom, Tartu, Estonia
de Klein, Niek, (författare)
Univ Groningen, Univ Med Ctr Groningen, Dept Genet, Groningen, Netherlands
Mishra, Pashupati P., (författare)
Fimlab Labs, Dept Clin Chem, Tampere, Finland;Univ Tampere, Fac Med & Life Sci, Dept Clin Chem, Finnish Cardiovasc Res Ctr Tampere, Tampere, Finland
Melton, Phillip E., (författare)
Curtin Univ, Sch Pharm & Biomed Sci, Bentley, WA, Australia;Univ Western Australia, Curtin UWA Ctr Genet Origins Hlth & Dis, Sch Biomed Sci, Crawley, Australia
Mandaviya, Pooja R., (författare)
Erasmus Univ, Dept Internal Med, Med Ctr, Rotterdam, Netherlands
Kasela, Silva, (författare)
Univ Tartu, Estonian Genome Ctr, Inst Genom, Tartu, Estonia
Nano, Jana, (författare)
Helmholtz Zentrum Munchen, Inst Epidemiol, German Res Ctr Environm Hlth, Neuherberg, Bavaria, Germany;Erasmus Univ, Dept Epidemiol, Med Ctr, Rotterdam, Netherlands
Zhang, Weihua, (författare)
Imperial Coll London, MRC PHE Ctr Environm & Hlth, Sch Publ Hlth, Dept Epidemiol & Biostat, London, England;North West Healthcare NHS Trust, Dept Cardiol, Ealing Hosp, London, England
Zhang, Yan, (författare)
German Canc Res Ctr, Div Clin Epidemiol & Aging Res, Heidelberg, Germany
Uitterlinden, Andre G., (författare)
Erasmus Univ, Dept Internal Med, Med Ctr, Rotterdam, Netherlands;Erasmus Univ, Dept Epidemiol, Med Ctr, Rotterdam, Netherlands
Peters, Annette, (författare)
Helmholtz Zentrum Munchen, Res Unit Mol Epidemiol, German Res Ctr Environm Hlth, Neuherberg, Bavaria, Germany;Helmholtz Zentrum Munchen, Inst Epidemiol, German Res Ctr Environm Hlth, Neuherberg, Bavaria, Germany;German Ctr Cardiovasc Res DZHK, Partner Site Munich Heart Alliance, Munich, Germany
Schoettker, Ben, (författare)
German Canc Res Ctr, Div Clin Epidemiol & Aging Res, Heidelberg, Germany;Heidelberg Univ, Network Aging Res, Bergheimer Str, Heidelberg, Germany
Gieger, Christian, (författare)
Helmholtz Zentrum Munchen, Res Unit Mol Epidemiol, German Res Ctr Environm Hlth, Neuherberg, Bavaria, Germany;Helmholtz Zentrum Munchen, Inst Epidemiol, German Res Ctr Environm Hlth, Neuherberg, Bavaria, Germany;German Ctr Cardiovasc Res DZHK, Partner Site Munich Heart Alliance, Munich, Germany
Anderson, Denise, (författare)
Univ Western Australia, Telethon Kids Inst, Perth, WA, Australia
Boomsma, Dorret, I, (författare)
Vrije Univ Amsterdam, Sch Publ Hlth, Dept Biol Psychol, Amsterdam, Netherlands
Grabe, Hans J., (författare)
Univ Med Greifswald, Dept Psychiat & Psychotherapy, Greifswald, Germany;German Ctr Neurodegenerat Dis DZNF, Site Rostock Greifswald, Greifswald, Germany
Panico, Salvatore, (författare)
Univ Naples Federico II, Dept Clin Med & Surg, Naples, Italy
Veldink, Jan H., (författare)
Univ Med Ctr Utrecht, Brain Ctr Rudolf Magnus, Dept Neurol, Utrecht, Netherlands
van Meurs, Joyce B. J., (författare)
Erasmus Univ, Dept Internal Med, Med Ctr, Rotterdam, Netherlands
van den Berg, Leonard, (författare)
Univ Med Ctr Utrecht, Brain Ctr Rudolf Magnus, Dept Neurol, Utrecht, Netherlands
Beilin, Lawrence J., (författare)
Univ Western Australia, Med Sch, Perth, WA, Australia
Franke, Lude, (författare)
Univ Groningen, Univ Med Ctr Groningen, Dept Genet, Groningen, Netherlands
Loh, Marie, (författare)
Imperial Coll London, MRC PHE Ctr Environm & Hlth, Sch Publ Hlth, Dept Epidemiol & Biostat, London, England;ASTAR, TLGM, 8A Biomed Grove,Level 5, Singapore, Singapore;Univ Oulu, Inst Hlth Sci, Oulu, Finland
van Greevenbroek, Marleen M. J., (författare)
Maastricht Univ, Dept Internal Med, Med Ctr, Maastricht, Netherlands;Maastricht Univ, Sch Cardiovasc Dis CARIM, Med Ctr, Maastricht, Netherlands
Nauck, Matthias, (författare)
DZHK German Ctr Cardiovasc Res, Partner Site Greifswald, Greifswald, Germany;Univ Med Greifswald, Inst Clin Chem & Lab Med, Greifswald, Germany
Kahonen, Mika, (författare)
Tampere Univ Hosp, Dept Clin Physiol, Tampere, Finland;Univ Tampere, Fac Med & Life Sci, Finnish Cardiovasc Res Ctr Tampere, Dept Clin Physiol, Tampere, Finland
Hurme, Mikko A., (författare)
Fac Med & Life Sci Univ Tampere, Dept Microbiol & Immunol, Tampere, Finland
Raitakari, Olli T., (författare)
Turku Univ Hosp, Dept Clin Physiol & Nucl Med, Turku, Finland;Univ Turku, Res Ctr Appl & Prevent Cardiovasc Med, Turku, Finland
Franco, Oscar H., (författare)
Erasmus Univ, Dept Epidemiol, Med Ctr, Rotterdam, Netherlands
Slagboom, P. Eline, (författare)
Leiden Univ, Dept Biomed Data Sci, Mol Epidemiol, Med Ctr, Leiden, Netherlands
van der Harst, Pim, (författare)
Univ Groningen, Univ Med Ctr Groningen, Dept Genet, Groningen, Netherlands;Univ Groningen, Univ Med Ctr Groningen, Dept Cardiol, Groningen, Netherlands;ICIN Netherlands Heart Inst, Durrer Ctr Cardiogenet Res, Utrecht, Netherlands
Kunze, Sonja, (författare)
Helmholtz Zentrum Munchen, Res Unit Mol Epidemiol, German Res Ctr Environm Hlth, Neuherberg, Bavaria, Germany;Helmholtz Zentrum Munchen, Inst Epidemiol, German Res Ctr Environm Hlth, Neuherberg, Bavaria, Germany
Felix, Stephan B., (författare)
DZHK German Ctr Cardiovasc Res, Partner Site Greifswald, Greifswald, Germany
Zhang, Tao, (författare)
Tulane Univ, Sch Publ Hlth & Trop Med, Dept Epidemiol, New Orleans, LA USA;Shandong Univ, Sch Publ Hlth, Dept Biostat, Jinan, Shandong, Peoples R China
Chen, Wei, (författare)
Tulane Univ, Sch Publ Hlth & Trop Med, Dept Epidemiol, New Orleans, LA USA
Mori, Trevor A., (författare)
Univ Western Australia, Med Sch, Perth, WA, Australia
Bonnefond, Amelie, (författare)
Imperial Coll London, Dept Med, Genom Common Dis, London, England;Univ Lille, EGID, Inst Pasteur Lille, CMS UMR 8199, Lille, France
Heijmans, Bastiaan T., (författare)
Leiden Univ, Dept Biomed Data Sci, Mol Epidemiol, Med Ctr, Leiden, Netherlands
Muka, Taulant, (författare)
Erasmus Univ, Dept Epidemiol, Med Ctr, Rotterdam, Netherlands
Kooner, Jaspal S., (författare)
Imperial Coll London, MRC PHE Ctr Environm & Hlth, Sch Publ Hlth, Dept Epidemiol & Biostat, London, England;North West Healthcare NHS Trust, Dept Cardiol, Ealing Hosp, London, England;Imperial Coll London, Natl Heart & Lung Inst, London, England;Childrens Minnesota Res Inst, Childrens Hosp & Clin, Minneapolis, MN 55404 USA
Fischer, Krista, (författare)
Univ Tartu, Estonian Genome Ctr, Inst Genom, Tartu, Estonia
Waldenberger, Melanie, (författare)
Helmholtz Zentrum Munchen, Res Unit Mol Epidemiol, German Res Ctr Environm Hlth, Neuherberg, Bavaria, Germany;Helmholtz Zentrum Munchen, Inst Epidemiol, German Res Ctr Environm Hlth, Neuherberg, Bavaria, Germany;German Ctr Cardiovasc Res DZHK, Partner Site Munich Heart Alliance, Munich, Germany
Froguel, Philippe, (författare)
Imperial Coll London, Dept Med, Genom Common Dis, London, England;Univ Lille, EGID, Inst Pasteur Lille, CMS UMR 8199, Lille, France
Huang, Rae-Chi, (författare)
Univ Western Australia, Telethon Kids Inst, Perth, WA, Australia
Lehtimaki, Terho, (författare)
Fimlab Labs, Dept Clin Chem, Tampere, Finland;Univ Tampere, Fac Med & Life Sci, Dept Clin Chem, Finnish Cardiovasc Res Ctr Tampere, Tampere, Finland
Rathmann, Wolfgang, (författare)
Heine Univ, Inst Biometr & Epidemiol, Leibniz Ctr Diabet Res Heinrich, German Diabet Ctr, Dusseldorf, Germany
Relton, Caroline L., (författare)
Univ Bristol, Bristol Med Sch, MRC Integrat Epidemiol Unit, Populat Hlth Sci, Bristol, Avon, England
Matullo, Giuseppe, (författare)
Univ Turin, Dept Med Sci, Turin, Italy;IIGM, Turin, Italy
Brenner, Hermann, (författare)
German Canc Res Ctr, Div Clin Epidemiol & Aging Res, Heidelberg, Germany;Heidelberg Univ, Network Aging Res, Bergheimer Str, Heidelberg, Germany
Verweij, Niek, (författare)
Univ Groningen, Univ Med Ctr Groningen, Dept Cardiol, Groningen, Netherlands
Li, Shengxu, (författare)
Childrens Minnesota Res Inst, Childrens Hosp & Clin, Minneapolis, MN 55404 USA
Chambers, John C., (författare)
Imperial Coll London, MRC PHE Ctr Environm & Hlth, Sch Publ Hlth, Dept Epidemiol & Biostat, London, England;North West Healthcare NHS Trust, Dept Cardiol, Ealing Hosp, London, England;Imperial Coll Healthcare NHS Trust, London, England;Nanyang Technol Univ Singapore, Lee Kong Chian Sch Med, Singapore, Singapore
Jarvelin, Marjo-Riitta, (författare)
Univ Oulu, Ctr Life Course Hlth Res, Oulu, Finland;Univ Oulu, Bioctr Oulu, Oulu, Finland;Imperial Coll London, MRC PHE Ctr Environm & Hlth, Sch Publ Hlth, Dept Epidemiol & Biostat, London, England;Brunel Univ London, Dept Life Sci, Coll Hlth & Life Sci, Uxbridge, Middx, England
Sebert, Sylvain, (författare)
Univ Oulu, Ctr Life Course Hlth Res, Oulu, Finland;Univ Oulu, Bioctr Oulu, Oulu, Finland;Univ Oulu, Med Res Ctr MRC Oulu, Oulu Univ Hosp, Oulu, Finland
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Uppsala universitet Medicinska och farmaceutiska vetenskapsområdet. Medicinska fakulteten. Institutionen för medicinska vetenskaper. Molekylär medicin. (creator_code:org_t)
2018
Engelska.
Ingår i: EBioMedicine. - 2352-3964. ; 38, s. 206-216
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • Background: DNA methylation at the GFI1-locus has been repeatedly associated with exposure to smoking from the foetal period onwards. We explored whether DNA methylation may be a mechanism that links exposure to maternal prenatal smoking with offspring's adult cardio-metabolic health. Methods: We meta-analysed the association between DNA methylation at GFI1-locus with maternal prenatal smoking, adult own smoking, and cardio-metabolic phenotypes in 22 population-based studies from Europe, Australia, and USA (n= 18,212). DNA methylation at the GFI1-locus was measured in whole-blood. Multivariable regression models were fitted to examine its association with exposure to prenatal and own adult smoking. DNA methylation levels were analysed in relation to body mass index (BMI), waist circumference (WC), fasting glucose (FG), high-density lipoprotein cholesterol (HDL-C), triglycerides (TG), diastolic, and systolic blood pressure (BP). Findings: Lower DNA methylation at three out of eight GFI1-CpGs was associated with exposure to maternal prenatal smoking, whereas, all eight CpGs were associated with adult own smoking. Lower DNA methylation at cg14179389, the strongest maternal prenatal smoking locus, was associated with increased WC and BP when adjusted for sex, age, and adult smoking with Bonferroni-corrected P < 0.012. In contrast, lower DNA methylation at cg09935388, the strongest adult own smoking locus, was associated with decreased BMI, WC, and BP (adjusted 1 x 10(-7) < P < 0.01). Similarly, lower DNA methylation at cg12876356, cg18316974, cg09662411, and cg18146737 was associated with decreased BMI and WC (5 x 10(-8) < P < 0.001). Lower DNA methylation at all the CpGs was consistently associated with higher TG levels. Interpretation: Epigenetic changes at the GFI1 were linked to smoking exposure in-utero/in-adulthood and robustly associated with cardio-metabolic risk factors. Fund: European Union's Horizon 2020 research and innovation programme under grant agreement no. 633595 DynaHEALTH.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska grundvetenskaper -- Medicinsk genetik (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Medical Genetics (hsv//eng)

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