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Blood inflammatory and endothelial markers in women with von Willebrand disease

Govorov, Igor (författare)
Karolinska Institutet, Department of Women's and Children's Health, Stockholm, Sweden
Bremme, Katarina (författare)
Karolinska Institutet, Department of Women's and Children's Health, Stockholm, Sweden
Larsson, Anders (författare)
Uppsala universitet,Klinisk kemi
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Holmström, Margareta (författare)
Karolinska University Hospital Solna, Department of Medicine, Stockholm, Sweden
Komlichenko, Eduard (författare)
Almazov National Medical Research Centre, Institution of Pediatrics and Perinatology, Saint-Petersburg, Russia
Chaireti, Roza (författare)
Karolinska Institutet, Department of Molecular Medicine and Surgery, Stockholm, Sweden
Mints, Miriam (författare)
Karolinska Institutet, Department of Women's and Children's Health, Stockholm, Sweden
Bremme, K (författare)
Karolinska Institutet
Mints, M (författare)
Karolinska Institutet
Holmstrom, M (författare)
Karolinska Institutet
Larsson, A (författare)
Chaireti, R (författare)
Karolinska Institutet
Govorov, I (författare)
Karolinska Institutet
Komlichenko, E (författare)
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Ingår i: PLoS ONE. - 1932-6203 .- 1932-6203. ; 14:1
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
  • Introduction: VWD-affected females often experience menorrhagia. Periodical fluctuations of the sex steroids during the menstrual cycle cause changes both in the coagulation and immune system. The aim of the current study was to assess the changes in selected inflammatory and endothelial markers in women with VWD during two phases of the menstrual cycle (follicular and luteal) and to compare it with corresponding data from healthy controls.Materials and methods: The study group included 12 VWD-affected females with regular menstrual cycle, with none of them being prescribed hormone treatment. They were not pregnant or breastfeeding. The control group consisted of 102 healthy females, matched for age and BMI.Results: Within the VWD group, endostatin was higher during the follicular phase, compared to the luteal phase, although the difference was not significant (p = 0.062). sICAM-1 and IL-6 were higher in VWD-affected females, compared to the controls, sVCAM-1, cathepsin S and sP-selectin were lower (p<0.003 for all cases). The pattern was constant throughout the menstrual cycle.Conclusions: Higher levels of endostatin during early follicular phase could potentially predispose women with VWD to the development of heavy menstrual bleeding, due to antiangiogenic properties and ability to suppress several coagulation factors. Lower p-selectin levels in VWD group, compared to controls, may also contribute to the bleeding tendency. Changes in other proteins, involved in angiogenesis are hypothetically related to the formation of angiodysplasia—common complication of VWF deficiency. The latter statement requires confirmation in larger studies.


MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Obstetrics, Gynecology and Reproductive Medicine (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine (hsv//eng)

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