Brigham & Womens Hosp, Div Urol Surg, Boston, MA 02115 USA.
Vega, Ana (författare)
Fdn Publ Galega Med Xenom SERGAS, CIBERER, IDIS, Grp Med Xenom, Santiago De Compostela 15706, Spain.
Bensen, Jeanette T. (författare)
Univ N Carolina, Gillings Sch Global Publ Hlth, Dept Epidemiol, Columbia, SC 29208 USA.
Kogevinas, Manolis (författare)
Barcelona Inst Global Hlth ISGlobal, Ctr Res Environm Epidemiol CREAL, Barcelona 08003, Spain.;CIBER Epidemiol & Salud Publ CIBERESP, Madrid 28029, Spain.;Hosp del Mar, IMIM, Res Inst, Barcelona 08003, Spain.;UPF, Barcelona 08002, Spain.
Penney, Kathryn L. (författare)
Harvard Med Sch, Dept Med, Channing Div Network Med, Brigham & Womens Hosp, Boston, MA 02184 USA.
Park, Jong Y. (författare)
H Lee Moffitt Canc Ctr & Res Inst, Dept Canc Epidemiol, Tampa, FL 33612 USA.
Stanford, Janet L. (författare)
Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Seattle, WA 98109 USA.;Univ Washington, Sch Publ Hlth, Dept Epidemiol, Seattle, WA 98195 USA.
Cybulski, Cezary (författare)
Pomeranian Med Univ, Int Hereditary Canc Ctr, Dept Genet & Pathol, PL-70115 Szczecin, Poland.
Univ Manchester, Manchester Acad Hlth Sci Ctr, Fac Biol Med & Hlth,Hlth Innovat Manchester, Manchester Canc Res Ctr,NIHR Manchester Biomed Re, Manchester M13 9WL, Lancs, England.
Dominguez, Manuela G. (författare)
Complejo Hosp Univ Santiago, Inst Invest Sanitaria Santiago de Compostela IDIS, SERGAS, Genom Med Grp,Galician Fdn Genom Med,Serv Galego, Santiago De Compostela 15706, Spain.;Univ Calif San Diego, Moores Canc Ctr, La Jolla, CA 92037 USA.
Roobol, Monique J. (författare)
Erasmus Univ, Dept Urol, Med Ctr, NL-3015 CE Rotterdam, Netherlands.
Menegaux, Florence (författare)
Univ Paris Sud, Univ Paris Saclay, Ctr Res Epidemiol & Populat Hlth CESP, INSERM,Canc & Environm Grp, F-94807 Villejuif, France.
Khaw, Kay-Tee (författare)
Univ Cambridge, Clin Gerontol Unit, Cambridge CB2 2QQ, England.
Cannon-Albright, Lisa A. (författare)
Univ Utah, Dept Med, Div Genet Epidemiol, Sch Med, Salt Lake City, UT 84112 USA.;George E Wahlen Dept Vet Affairs Med Ctr, Salt Lake City, UT 84148 USA.
Pandha, Hardev (författare)
Univ Surrey, Guildford GU2 7XH, Surrey, England.
Thibodeau, Stephen N. (författare)
Mayo Clin, Dept Lab Med & Pathol, Rochester, MN 55905 USA.
Schaid, Daniel J. (författare)
Mayo Clin, Div Biomed Stat & Informat, Rochester, MN 55905 USA.
Wiklund, Fredrik (författare)
Karolinska Inst, Dept Med Epidemiol & Biostat, SE-17177 Stockholm, Sweden.
Chanock, Stephen J. (författare)
NCI, Div Canc Epidemiol & Genet, NIH, Bethesda, MD 20892 USA.
Chromosome 8q24 is a susceptibility locus for multiple cancers, including prostate cancer. Here we combine genetic data across the 8q24 susceptibility region from 71,535 prostate cancer cases and 52,935 controls of European ancestry to define the overall contribution of germline variation at 8q24 to prostate cancer risk. We identify 12 independent risk signals for prostate cancer (p < 4.28 x 10(-15)), including three risk variants that have yet to be reported. From a polygenic risk score (PRS) model, derived to assess the cumulative effect of risk variants at 8q24, men in the top 1% of the PRS have a 4-fold (95% CI = 3.62-4.40) greater risk compared to the population average. These 12 variants account for similar to 25% of what can be currently explained of the familial risk of prostate cancer by known genetic risk factors. These findings highlight the overwhelming contribution of germline variation at 8q24 on prostate cancer risk which has implications for population risk stratification.
Ämnesord
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)