Fimlab Labs, Dept Clin Chem, Tampere 33520, Finland;Univ Tampere, Fac Med & Life Sci, Finnish Cardiovasc Res Ctr Tampere, Dept Clin Chem, Tampere 33014, Finland
Iceland Heart Assoc, IS-201 Kopavogur, Iceland;Univ Iceland, Fac Med, IS-101 Reykjavik, Iceland;Univ Michigan, Dept Biostat, Ann Arbor, MI 48109 USA
Steri, Maristella (författare)
CNR, Ist Ric Genet & Biomed, I-00185 Cagliari, Italy
Tanaka, Toshiko (författare)
NIA, Translat Gerontol Branch, Bethesda, MD 20892 USA
Teumer, Alexander (författare)
Univ Med Greifswald, Inst Community Med, D-17489 Greifswald, Germany;DZHK German Ctr Cardiovasc Res, Partner Site Greifswald, D-17475 Greifswald, Germany
Broad Inst MIT & Harvard, Program Med & Populat Genet, Cambridge, MA 02142 USA;Massachusetts Gen Hosp, Cardiovasc Res Ctr, Boston, MA 02114 USA;Massachusetts Gen Hosp, Cardiac Arrhythmia Serv, Boston, MA 02114 USA
Felix, Stephan B. (författare)
DZHK German Ctr Cardiovasc Res, Partner Site Greifswald, D-17475 Greifswald, Germany;Univ Med Greifswald, Dept Internal Med B, D-17489 Greifswald, Germany
Tampere Univ Hosp, Dept Clin Physiol, Tampere 33521, Finland;Univ Tampere, Finnish Cardiovasc Res Ctr Tampere, Fac Med & Life Sci, Dept Clin Physiol, Tampere 33014, Finland
Kolcic, Ivana (författare)
Univ Split, Fac Med, Split 21000, Croatia
Kors, Jan A. (författare)
Erasmus Univ, Med Ctr, Dept Med Informat, NL-3015 GD Rotterdam, Netherlands
Lakatta, Edward G. (författare)
NIA, Lab Cardiovasc Sci, NIH, Bethesda, MD 20892 USA
Launer, Lenore J. (författare)
NIA, Lab Epidemiol & Populat Sci, Intramural Res Program, NIH, Bethesda, MD 20892 USA
Lin, Honghuang (författare)
Boston Univ, Sch Med, Dept Med, Boston, MA 02118 USA
Lin, Henry J. (författare)
Harbor UCLA Med Ctr, Los Angeles Biomed Res Inst, Inst Translat Genom & Populat Sci, Dept Pediat, Torrance, CA 90502 USA
Loos, Ruth J. F. (författare)
Icahn Sch Med Mt Sinai, Charles Bronfman Inst Personalized Med, New York, NY 10029 USA;Icahn Sch Med Mt Sinai, Mindich Child Hlth & Dev Inst, New York, NY 10029 USA
Lubitz, Steven A. (författare)
Broad Inst MIT & Harvard, Program Med & Populat Genet, Cambridge, MA 02142 USA;Massachusetts Gen Hosp, Cardiovasc Res Ctr, Boston, MA 02114 USA;Massachusetts Gen Hosp, Cardiac Arrhythmia Serv, Boston, MA 02114 USA
Macfarlane, Peter W. (författare)
Univ Glasgow, Inst Hlth & Wellbeing, Coll Med Vet & Life Sci, Glasgow G12 8QQ, Lanark, Scotland
Magnani, Jared W. (författare)
Univ Pittsburgh, Med Ctr, Heart & Vasc Inst, Dept Med,Div Cardiol, Pittsburgh, PA 15260 USA
Turku Univ Hosp, Dept Clin Physiol & Nucl Med, Turku 20521, Finland;Univ Turku, Res Ctr Appl & Prevent Cardiovasc Med, Turku 20014, Finland
Rotter, Jerome I. (författare)
Harbor UCLA Med Ctr, Los Angeles Biomed Res Inst, Inst Translat Genom & Populat Sci, Dept Pediat, Torrance, CA 90502 USA;Harbor UCLA Med Ctr, Los Angeles Biomed Res Inst, Inst Translat Genom & Populat Sci, Dept Med, Torrance, CA 90502 USA
DZHK German Ctr Cardiovasc Res, Partner Site Greifswald, D-17475 Greifswald, Germany;Univ Med Greifswald, Interfac Inst Genet & Funct Genom, D-17489 Greifswald, Germany
Voelzke, Henry (författare)
Univ Med Greifswald, Inst Community Med, D-17489 Greifswald, Germany;DZHK German Ctr Cardiovasc Res, Partner Site Greifswald, D-17475 Greifswald, Germany
Waldenberger, Melanie (författare)
DZHK German Ctr Cardiovasc Res, Partner Site Munich Heart Alliance, D-80802 Munich, Germany;German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Inst Epidemiol, D-85764 Neuherberg, Germany;German Res Ctr Environm Hlth, Helmholtz Zentrum Munchen, Res Unit Mol Epidemiol, D-85764 Neuherberg, Germany
CNR, Ist Ric Genet & Biomed, I-00185 Cagliari, Italy
Doerr, Marcus (författare)
DZHK German Ctr Cardiovasc Res, Partner Site Greifswald, D-17475 Greifswald, Germany;Univ Med Greifswald, Dept Internal Med B, D-17489 Greifswald, Germany
Ferrucci, Luigi (författare)
NIA, Translat Gerontol Branch, Bethesda, MD 20892 USA
Hosp Ludwig Maximilians Univ LMU Munich, Dept Internal Med Cardiol 1, D-81377 Munich, Germany;DZHK German Ctr Cardiovasc Res, Partner Site Munich Heart Alliance, D-80802 Munich, Germany
Lehtimaki, Terho (författare)
Fimlab Labs, Dept Clin Chem, Tampere 33520, Finland;Univ Tampere, Fac Med & Life Sci, Finnish Cardiovasc Res Ctr Tampere, Dept Clin Chem, Tampere 33014, Finland
Liu, Yongmei (författare)
Wake Forest Univ, Div Publ Hlth Sci, Dept Epidemiol & Prevent, Winston Salem, NC 27101 USA
Munroe, Patricia B. (författare)
Queen Mary Univ London, William Harvey Res Inst, Clin Pharmacol, London E1 4NS, England;Barts Hlth NHS Trust & Queen Mary Univ London, NIHR Biomed Res Ctr, London E1 4NS, England
Parsa, Afshin (författare)
Univ Maryland, Sch Med, Dept Med, Baltimore, MD 21201 USA;Baltimore VA Med Ctr, Baltimore, MD 21201 USA
Polasek, Ozren (författare)
Univ Split, Fac Med, Split 21000, Croatia;Psychiat Hosp Sveti Ivan, Zagreb 10000, Croatia;Gen Info Ltd, Zagreb 10000, Croatia
Psaty, Bruce M. (författare)
Univ Washington, Cardiovasc Hlth Res Unit, Dept Med, Seattle, WA 98195 USA;Univ Washington, Cardiovasc Hlth Res Unit, Dept Epidemiol & Hlth Serv, Seattle, WA 98195 USA;Kaiser Permanente Washington Hlth Res Inst, Seattle, WA 98101 USA
Roden, Dan M. (författare)
Fimlab Labs, Dept Clin Chem, Tampere 33520, Finland;Vanderbilt Univ, Med Pharmacol & Biomed Informat, Nashville, TN 37235 USA
Univ Washington, Cardiovasc Hlth Res Unit, Div Cardiol, Dept Med, Seattle, WA 98101 USA;Univ Washington, Cardiovasc Hlth Res Unit, Div Cardiol, Dept Epidemiol, Seattle, WA 98101 USA
Electrocardiographic PR interval measures atrio-ventricular depolarization and conduction, and abnormal PR interval is a risk factor for atrial fibrillation and heart block. Our genomewide association study of over 92,000 European-descent individuals identifies 44 PR interval loci (34 novel). Examination of these loci reveals known and previously not-yet-reported biological processes involved in cardiac atrial electrical activity. Genes in these loci are overrepresented in cardiac disease processes including heart block and atrial fibrillation. Variants in over half of the 44 loci were associated with atrial or blood transcript expression levels, or were in high linkage disequilibrium with missense variants. Six additional loci were identified either by meta-analysis of similar to 105,000 African and European-descent individuals and/or by pleiotropic analyses combining PR interval with heart rate, QRS interval, and atrial fibrillation. These findings implicate developmental pathways, and identify transcription factors, ionchannel genes, and cell-junction/cell-signaling proteins in atrio-ventricular conduction, identifying potential targets for drug development.
Ämnesord
MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Basic Medicine (hsv//eng)