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Sökning: onr:"swepub:oai:DiVA.org:uu-387973" > Survival after radi...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00008156naa a2201021 4500
001oai:DiVA.org:uu-387973
003SwePub
008190627s2019 | |||||||||||000 ||eng|
009oai:DiVA.org:umu-158779
009oai:prod.swepub.kib.ki.se:141034358
009oai:DiVA.org:liu-158578
009oai:lup.lub.lu.se:cea12b58-f15a-4875-b7ae-ab84314a0082
024a urn:nbn:se:uu:diva-3879732 urn
024a https://doi.org/10.1002/cam4.21262 DOI
024a urn:nbn:se:umu:diva-1587792 urn
024a http://kipublications.ki.se/Default.aspx?queryparsed=id:1410343582 URI
024a urn:nbn:se:liu:diva-1585782 urn
024a https://lup.lub.lu.se/record/cea12b58-f15a-4875-b7ae-ab84314a00822 URI
040 a (SwePub)uud (SwePub)umu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
100a Häggström, Christelu Uppsala University,Umeå University,Umeå universitet,Uppsala universitet,Endokrinkirurgi,Umea Univ, Dept Biobank Res, Umea, Sweden,Enheten för biobanksforskning4 aut0 (Swepub:uu)chrha650
2451 0a Survival after radiotherapy versus radical cystectomy for primary muscle-invasive bladder cancer :b A Swedish nationwide population-based cohort study
264 1b WILEY,c 2019
338 a electronic2 rdacarrier
500 a Funding Agencies|Swedish Cancer Society [CAN 2013/472]
506 a gratis
506 a gratis
520 a Background: Studies of survival comparing radical cystectomy (RC) and radiotherapy for muscle-invasive bladder cancer have provided inconsistent results and have methodological limitations. The aim of the study was to investigate risk of death after radiotherapy as compared to RC.Methods: We selected patients with muscle-invasive urothelial carcinoma without distant metastases, treated with radiotherapy or RC from 1997 to 2014 in the Bladder Cancer Data Base Sweden (BladderBaSe) and estimated absolute and relative risk of bladder cancer death and all-cause death. In a group of patients, theoretically eligible for a trial comparing radiotherapy and RC, we calculated risk difference in an instrumental variable analysis. We have not investigated chemoradiotherapy as this treatment was not used in the study time period.Results: The study included 3 309 patients, of those 17% were treated with radiotherapy and 83% with RC. Patients treated with radiotherapy were older, had more advanced comorbidity, and had a higher risk of death as compared to patients treated with RC (relative risks of 1.5-1.6). In the "trial population," all-cause death risk difference was 6 per 100 patients lower after radiotherapy at 5 years of follow-up, 95% confidence interval -41 to 29.Conclusion(s): Patient selection between the treatments make it difficult to evaluate results from conventionally adjusted and propensity-score matched survival analysis. When taking into account unmeasured confounding by instrumental variable analysis, no differences in survival was found between the treatments for a selected group of patients. Further clinical studies are needed to characterize this group of patients, which can serve as a basis for future comparison studies for treatment recommendations.
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Urology and Nephrology0 (SwePub)302142 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Urologi och njurmedicin0 (SwePub)302142 hsv//swe
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicin0 (SwePub)3022 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicine0 (SwePub)3022 hsv//eng
653 a bladder cancer
653 a muscle-invasive
653 a radical cystectomy
653 a radiotherapy
653 a urothelial carcinoma
653 a bladder cancer; muscle-invasive; radical cystectomy; radiotherapy; urothelial carcinoma
653 a bladder cancer
700a Garmo, Hansu Kings Coll London, Sch Canc & Pharmaceut Sci, TOUR, London, England;Reg Canc Ctr Uppsala Orebro, Uppsala, Sweden,Kings Coll London, England; Reg Canc Ctr Uppsala Orebro, Sweden,King's College London4 aut
700a de Luna, Xavieru Umeå University,Umeå universitet,Statistik,Umea Univ, Dept Stat, USBE, Umea, Sweden,Umea Univ, Sweden4 aut
700a Van Hemelrijck, Miekeu Karolinska Institutet,King's College London4 aut
700a Söderkvist, Karinu Umeå University,Umeå universitet,Onkologi,Umea Univ, Dept Radiat Sci, Oncol, Umea, Sweden4 aut
700a Aljabery, Firasu Linköping University,Linköpings universitet,Institutionen för klinisk och experimentell medicin,Medicinska fakulteten,Region Östergötland, Urologiska kliniken i Östergötland4 aut
700a Ströck, Vivekau Sahlgrens Univ Hosp, Dept Urol, Gothenburg, Sweden,Sahlgrenska University Hospital4 aut
700a Hosseini, Abolfazlu Karolinska Univ Hosp, Dept Urol, Stockholm, Sweden,Karolinska Univ Hosp, Sweden,Karolinska University Hospital4 aut
700a Gårdmark, Trulsu Danderyd Hosp, Dept Clin Sci, Karolinska Inst, Stockholm, Sweden,Danderyd Hospital4 aut
700a Malmström, Per-Unou Uppsala universitet,Urologkirurgi4 aut0 (Swepub:uu)perunoms
700a Jahnson, Staffanu Linköping University,Linköpings universitet,Avdelningen för Kirurgi, Ortopedi och Onkologi,Medicinska fakulteten,Region Östergötland, Urologiska kliniken i Östergötland4 aut
700a Liedberg, Fredriku Lund University,Lunds universitet,Urologi - blåscancer, Malmö,Forskargrupper vid Lunds universitet,Urology - urothelial cancer, Malmö,Lund University Research Groups,Skåne University Hospital4 aut
700a Holmberg, Larsu Uppsala University,Uppsala universitet,Endokrinkirurgi,Kings Coll London, Sch Canc & Pharmaceut Sci, TOUR, London, England,Uppsala Univ, Sweden; Kings Coll London, England,King's College London4 aut0 (Swepub:uu)larsholmb
700a Haggstrom, C4 aut
700a Jahnson, S4 aut
700a Liedberg, F4 aut
700a Hosseini, A4 aut
700a Strock, V4 aut
700a Aljabery, F4 aut
700a Van Hemelrijck, M4 aut
700a Gardmark, Tu Karolinska Institutet4 aut0 (Swepub:ki)d7f28d2561f6f221cba6f4db9b7336ce
700a Holmberg, L4 aut
700a de Luna, X4 aut
700a Garmo, H4 aut
700a Malmstrom, PU4 aut
700a Soderkvist, K4 aut
700a Gardmark, Trulsu Danderyd Hosp, Sweden4 aut
700a Haggstrom, Christelu Uppsala Univ, Sweden; Umea Univ, Sweden4 aut
700a Malmstrom, Per-Unou Uppsala Univ, Sweden4 aut
700a Soderkvist, Karinu Umea Univ, Sweden4 aut
700a Strock, Vivekau Sahlgrens Univ Hosp, Sweden4 aut
700a Malmström, Per Unou Uppsala University4 aut
710a Uppsala universitetb Endokrinkirurgi4 org
773t Cancer Medicined : WILEYg 8:5, s. 2196-2204q 8:5<2196-2204x 2045-7634x 2045-7634
856u https://doi.org/10.1002/cam4.2126
856u http://uu.diva-portal.org/smash/get/diva2:1331644/FULLTEXT01.pdf
856u http://umu.diva-portal.org/smash/get/diva2:1314312/FULLTEXT02.pdf
856u http://liu.diva-portal.org/smash/get/diva2:1334867/FULLTEXT01.pdf
856u http://dx.doi.org/10.1002/cam4.2126x freey FULLTEXT
8564 8u http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-387973x lärosäteslänky Till lärosätets (uu) databas
8564 8u https://doi.org/10.1002/cam4.2126
8564 8u http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-158779x lärosäteslänky Till lärosätets (umu) databas
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:141034358
8564 8u http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-158578x lärosäteslänky Till lärosätets (liu) databas
8564 8u https://lup.lub.lu.se/record/cea12b58-f15a-4875-b7ae-ab84314a0082

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