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Surgical menopause in association with cognitive function and risk of dementia : A systematic review and meta-analysis

Georgakis, Marios K., (författare)
Univ Athens, Med Sch, Dept Hyg Epidemiol & Med Stat, 75M Asias Str, Athens 11745, Greece;Ludwig Maximilians Univ Munchen, Univ Hosp, Inst Stroke & Dementia Res ISD, Munich, Germany;Ludwig Maximilians Univ Munchen, Grad Sch System Neurosci GSN, Munich, Germany;LMU, Univ Hosp, Inst Stroke & Dementia Res, Feodor Lynen Str 17, D-81377 Munich, Germany
Beskou-Kontou, Theano, (författare)
Univ Athens, Med Sch, Dept Hyg Epidemiol & Med Stat, 75M Asias Str, Athens 11745, Greece
Theodoridis, Ioannis, (författare)
Univ Athens, Med Sch, Dept Hyg Epidemiol & Med Stat, 75M Asias Str, Athens 11745, Greece
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Skalkidou, Alkistis, 1977- (författare)
Uppsala universitet, Obstetrisk och reproduktiv hälsoforskning
Petridou, Eleni Th., (författare)
Univ Athens, Med Sch, Dept Hyg Epidemiol & Med Stat, 75M Asias Str, Athens 11745, Greece
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Ingår i: Psychoneuroendocrinology. - PERGAMON-ELSEVIER SCIENCE LTD. - 0306-4530 .- 1873-3360. ; 106, s. 9-19
  • Forskningsöversikt (refereegranskat)
Abstract Ämnesord
  • <p>Introduction: Experimental and epidemiological studies suggest female sex hormones to have long-lasting neuroprotective and anti-ageing properties. Surgically-induced menopause leads to a premature cessation of exposure to female sex hormones and could thus impact late-life cognitive function. Yet, evidence remains controversial. Methods: We systematically reviewed literature for articles investigating the association of surgical menopause (defined as bilateral oophorectomy before the onset of menopause) with risk of dementia, cognitive performance, cognitive decline, and Alzheimer's disease neuropathological indices later in life. We evaluated study quality with the Newcastle-Ottawa scale and performed random-effects meta-analyses. Results: We identified 11 eligible studies (N = 18,867). Although surgical menopause at any age was not associated with risk of dementia (4 studies; HR: 1.16, 95%CI: 0.96-1.43), early surgical menopause (&lt;= 45 years of age) was associated with a statistically significantly higher risk (2 studies; HR: 1.70, 95%CI: 1.07-2.69). Surgical menopause at any age was associated with faster decline in verbal memory, semantic memory, and processing speed, whereas early surgical menopause was further associated with faster global cognitive decline. No heterogeneity was noted. Among women undergoing surgical menopause, a younger age at surgery was associated with faster decline in global cognition, semantic and episodic memory, worse performance in verbal fluency and executive function, and accumulation of Alzheimer's neuropathology. Conclusions: Current evidence is limited, but suggests surgical menopause induced by bilateral oophorectomy at &lt;= 45 years of age to be associated with higher risk of dementia and cognitive decline. Additional large-scale cohort studies are necessary to replicate these findings.</p>


MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska grundvetenskaper -- Neurovetenskaper (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Neurosciences (hsv//eng)


Cognitive impairment

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