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Sökning: onr:"swepub:oai:DiVA.org:uu-393745" > Long-Term Safety Ex...

Long-Term Safety Experience with Telotristat Ethyl Across Five Clinical Studies in Patients with Carcinoid Syndrome

Anthony, Lowell B. (författare)
Univ Kentucky, Markey Canc Ctr, Lexington, KY USA
Kulke, Matthew H. (författare)
Boston Univ, Med Ctr, Boston, MA USA
Caplin, Martyn E. (författare)
Royal Free Hosp, ENETS Ctr Excellence, Neuroendocrine Tumor Unit, London, England
visa fler...
Bergsland, Emily (författare)
Univ Calif San Francisco, Dept Med, San Francisco, CA USA
Öberg, Kjell, 1946- (författare)
Uppsala universitet,Endokrin tumörbiologi
Pavel, Marianne (författare)
Charite, Dept Hepatol & Gastroenterol, Berlin, Germany
Hoersch, Dieter (författare)
Zentralklin Bad Berka, Ctr Neuroendocrine Tumors, Dept Gastroenterol Endocrinol, Bad Berka, Germany
Warner, Richard R. P. (författare)
Icahn Sch Med Mt Sinai, Div Gastroenterol, New York, NY 10029 USA
O'Dorisio, Thomas M. (författare)
Univ Iowa, Dept Internal Med Endocrinol & Metab, Iowa City, IA USA
Dillon, Joseph S. (författare)
Univ Iowa, Dept Internal Med Endocrinol & Metab, Iowa City, IA USA
Lapuerta, Pablo (författare)
Lexicon Pharmaceut Inc, The Woodlands, TX USA
Kassler-Taub, Kenneth (författare)
Lexicon Pharmaceut Inc, The Woodlands, TX USA
Liang, Wenjun (författare)
Lexicon Pharmaceut Inc, The Woodlands, TX USA
visa färre...
 (creator_code:org_t)
WILEY, 2019
2019
Engelska.
Ingår i: The Oncologist. - : WILEY. - 1083-7159 .- 1549-490X. ; 24:8, s. E662-E670
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • Background Patients with neuroendocrine tumors (NETs) and carcinoid syndrome experience considerable morbidity and mortality; carcinoid syndrome may be associated with shorter survival. Carcinoid syndrome is linked to tumoral secretion of serotonin and other bioactive substances. The subsequent debilitating diarrhea and urgency to defecate pose significant health risks. In previous studies, telotristat ethyl, a tryptophan hydroxylase inhibitor, was effective and well tolerated in treating carcinoid syndrome diarrhea. We present pooled safety data from five clinical trials with telotristat ethyl in patients with carcinoid syndrome. Subjects, Materials, and Methods Adverse events reported during telotristat ethyl treatment were pooled from two phase II and three phase III clinical trials in 239 patients with carcinoid syndrome. Long-term safety of telotristat ethyl and causes of hospitalization and death were reviewed; overall survival was estimated. Results Mean (median; range) duration of exposure and follow-up was 1.3 years (1.1 years; 1 week to 5.7 years), with 309 total patient-years of exposure. Leading causes of hospitalization were gastrointestinal disorders or were related to the underlying tumor and related treatment. Survival estimates at 1, 2, and 3 years were 93%, 88%, and 77%. Nearly all deaths were due to progression or complication of the underlying disease; none were attributable to telotristat ethyl. There was one death in year 4. Conclusion Based on long-term safety data, telotristat ethyl is well tolerated and has a favorable long-term safety profile in patients with carcinoid syndrome. Implications for Practice Carcinoid syndrome can cause persistent diarrhea, even in patients treated with somatostatin analogs. Across five clinical trials in patients with carcinoid syndrome, telotristat ethyl has been well tolerated and efficacious, providing clinicians with a new approach to help control carcinoid syndrome diarrhea, in addition to somatostatin analog therapy. By reducing the stool frequency in patients with carcinoid syndrome whose diarrhea is refractory to anticholinergics, such as loperamide and atropine/diphenoxylate, and somatostatin analog dose escalation, improvement in quality of life becomes an achievable goal.

Ämnesord

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine (hsv//eng)

Nyckelord

Malignant carcinoid syndrome
Tryptophan hydroxylase
Telotristat ethyl
Serotonin
Diarrhea
Neuroendocrine tumors

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