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Immunological monit...
Immunological monitoring of newly diagnosed CML patients treated with bosutinib or imatinib first-line
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- Kreutzman, Anna (författare)
- Univ Helsinki, Hematol Res Unit Helsinki, Haartmaninkatu 8, FIN-00290 Helsinki, Finland;Helsinki Univ Hosp, Dept Hematol, Comprehens Canc Ctr, Haartmaninkatu 8, FIN-00290 Helsinki, Finland;Univ Helsinki, Dept Clin Chem, Helsinki, Finland,University of Helsinki
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- Yadav, Bhagwan (författare)
- Univ Helsinki, Hematol Res Unit Helsinki, Haartmaninkatu 8, FIN-00290 Helsinki, Finland;Helsinki Univ Hosp, Dept Hematol, Comprehens Canc Ctr, Haartmaninkatu 8, FIN-00290 Helsinki, Finland;Univ Helsinki, Dept Clin Chem, Helsinki, Finland,University of Helsinki
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- Brummendorf, Tim H. (författare)
- Univ Klinikum RWTH Aachen, Dept Hematol & Oncol, Aachen, Germany,Universitätsklinikum der RWTH Aachen
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visa fler...
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- Gjertsen, Bjorn Tore (författare)
- Univ Bergen, Haukeland Univ Hosp, Dept Internal Med, Hematol Sect, Bergen, Norway;Univ Bergen, Dept Clin Sci, Bergen, Norway,University of Bergen,Haukeland University Hospital
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- Hee, Moon Lee (författare)
- Univ Helsinki, Hematol Res Unit Helsinki, Haartmaninkatu 8, FIN-00290 Helsinki, Finland;Helsinki Univ Hosp, Dept Hematol, Comprehens Canc Ctr, Haartmaninkatu 8, FIN-00290 Helsinki, Finland;Univ Helsinki, Dept Clin Chem, Helsinki, Finland,University of Helsinki
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- Janssen, Jeroen (författare)
- Vrije Univ Amsterdam Med Ctr, Dept Hematol, Amsterdam, Netherlands,Amsterdam UMC - Vrije Universiteit Amsterdam
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- Kasanen, Tiina (författare)
- Univ Helsinki, Hematol Res Unit Helsinki, Haartmaninkatu 8, FIN-00290 Helsinki, Finland;Helsinki Univ Hosp, Dept Hematol, Comprehens Canc Ctr, Haartmaninkatu 8, FIN-00290 Helsinki, Finland,University of Helsinki
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- Koskenvesa, Perttu (författare)
- Univ Helsinki, Hematol Res Unit Helsinki, Haartmaninkatu 8, FIN-00290 Helsinki, Finland;Helsinki Univ Hosp, Dept Hematol, Comprehens Canc Ctr, Haartmaninkatu 8, FIN-00290 Helsinki, Finland,University of Helsinki
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- Lotfi, Kourosh, 1966- (författare)
- Linköpings universitet,Linköping University,Östergötland County Council,Avdelningen för läkemedelsforskning,Medicinska fakulteten,Region Östergötland, Hematologiska kliniken US
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- Markevarn, Berit (författare)
- Umea Univ Hosp, Dept Hematol, Umea, Sweden,Norrland University Hospital
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- Stromberg, Ulla Ohlsson (författare)
- Uppsala University,Uppsala universitet,Hematologi,Uppsala University Hospital,Uppsala Univ, Sweden; Uppsala Univ Hosp, Sweden
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- Stentoft, Jesper (författare)
- Aarhus Univ Hosp, Dept Hematol, Aarhus, Denmark,Aarhus University Hospital
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- Stenke, Leif (författare)
- Karolinska Institutet,Karolinska Institute,Karolinska University Hospital,Karolinska Univ Hosp, Sweden; Karolinska Inst, Sweden
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- Söderlund, Stina (författare)
- Uppsala University,Uppsala universitet,Hematologi,Klinisk immunologi,Uppsala University Hospital,Uppsala Univ Hosp, Sweden
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- Udby, Lene (författare)
- Zealand Univ Hosp, Dept Hematol, Roskilde, Denmark,Zealand University Hospital
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- Richter, Johan (författare)
- Lund University,Lunds universitet,Skåne University Hospital,Skane Univ Hosp, Sweden
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- Hjorth-Hansen, Henrik (författare)
- St Olavs Hosp, Dept Hematol, Trondheim, Norway;Norwegian Univ Sci & Technol NTNU, Dept Clin & Mol Med IKOM, Trondheim, Norway,St. Olav’s University Hospital,Norwegian University of Science and Technology
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- Mustjoki, Satu (författare)
- Univ Helsinki, Hematol Res Unit Helsinki, Haartmaninkatu 8, FIN-00290 Helsinki, Finland;Helsinki Univ Hosp, Dept Hematol, Comprehens Canc Ctr, Haartmaninkatu 8, FIN-00290 Helsinki, Finland;Univ Helsinki, Dept Clin Chem, Helsinki, Finland,University of Helsinki
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(creator_code:org_t)
- TAYLOR & FRANCIS INC, 2019
- 2019
- Engelska.
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Ingår i: Oncoimmunology. - : TAYLOR & FRANCIS INC. - 2162-4011 .- 2162-402X. ; 8:9
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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http://dx.doi.org/10... (free)
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https://liu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://lup.lub.lu.s...
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http://kipublication...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Changes in the immune system induced by tyrosine kinase inhibitors (TKI) have been shown to positively correlate with therapy responses in chronic myeloid leukemia (CML). However, only a few longitudinal studies exist and no randomized comparisons between two TKIs have been reported. Therefore, we prospectively analyzed the immune system of newly diagnosed CML patients treated with imatinib (n = 20) or bosutinib (n = 13), that participated in the randomized BFORE trial (NCT02130557). Comprehensive immunophenotyping, plasma protein profiling, and functional assays to determine activation levels of T and NK cells were performed at diagnosis, 3, and 12 months after therapy start. All results were correlated with clinical parameters such as Sokal risk and BCR-ABL load measured according to IS%. At diagnosis, low Sokal risk CML patients had a higher frequency of cytotoxic cells (CD8 + T and NK cells), increased cytotoxic potential of NK cells and lower frequency of naive and central memory CD4 + T cells. Further, soluble plasma protein profile divided patients into two distinct clusters with different disease burden at diagnosis. During treatment, BCR-ABL IS% correlated with immunological parameters such as plasma proteins, together with different memory subsets of CD4+ and CD8 + T cells. Interestingly, the proportion and cytotoxic potential of NK cells together with several soluble proteins increased during imatinib treatment. In contrast, no major immunological changes were observed during bosutinib treatment. In conclusion, imatinib and bosutinib were shown to have differential effects on the immune system in this randomized clinical trial. Increased number and function of NK cells were especially observed during imatinib therapy.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
Nyckelord
- CML
- imatinib
- bosutinib
- Sokal
- BCR-ABL
- BCR-ABL
- bosutinib
- CML
- imatinib
- Sokal
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Kreutzman, Anna
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Yadav, Bhagwan
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Brummendorf, Tim ...
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Gjertsen, Bjorn ...
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Hee, Moon Lee
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Janssen, Jeroen
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visa fler...
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Kasanen, Tiina
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Koskenvesa, Pert ...
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Lotfi, Kourosh, ...
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Markevarn, Berit
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Stromberg, Ulla ...
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Stentoft, Jesper
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Stenke, Leif
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Söderlund, Stina
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Udby, Lene
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Richter, Johan
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Hjorth-Hansen, H ...
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Mustjoki, Satu
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Hematologi
- Artiklar i publikationen
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Oncoimmunology
- Av lärosätet
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Uppsala universitet
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Lunds universitet
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Karolinska Institutet
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Linköpings universitet