Univ Southern Calif, Keck Sch Med, USC Mark & Mary Stevens Neuroimaging & Informat I, Imaging Genet Ctr, Los Angeles, CA USA;Univ N Carolina, Dept Genet, Chapel Hill, NC 27515 USA;Univ N Carolina, UNC Neurosci Ctr, Chapel Hill, NC 27515 USA
Scholz, Markus (författare)
Univ Leipzig, Inst Med Informat Stat & Epidemiol, Leipzig, Germany;Univ Leipzig, LIFE Leipzig Res Ctr Civilizat Dis, Leipzig, Germany
Sargurupremraj, Muralidharan (författare)
Univ Bordeaux, Bordeaux Populat Hlth Res Ctr, Team Vintage, INSERM,UMR 1219, Bordeaux, France
Jahanshad, Neda (författare)
Univ Southern Calif, Keck Sch Med, USC Mark & Mary Stevens Neuroimaging & Informat I, Imaging Genet Ctr, Los Angeles, CA USA
Univ Edinburgh, Royal Edinburgh Hosp, Div Psychiat, Edinburgh, Midlothian, Scotland;Univ Bern, Univ Hosp Psychiat, Translat Res Ctr, Div Syst Neurosci Psychopathol, Bern, Switzerland
Axelsson, Tomas (författare)
Uppsala universitet,Molekylär medicin,Science for Life Laboratory, SciLifeLab
Ehrlich, Stefan (författare)
Massachusetts Gen Hosp, Dept Psychiat, Boston, MA 02114 USA;Tech Univ Dresden, Div Psychol & Social Med & Dev Neurosci, Fac Med, Dresden, Germany;Massachusetts Gen Hosp, Martinos Ctr Biomed Imaging, Charlestown, MA USA
Univ Cape Town, Dept Psychiat & Mental Hlth, Cape Town, South Africa;South African Med Res Council, Unit Risk & Resilience Mental Disorders, Cape Town, South Africa
Stevens, Allison (författare)
Massachusetts Gen Hosp, Martinos Ctr Biomed Imaging, Charlestown, MA USA
Bralten, Janita (författare)
Radboud Univ Nijmegen, Dept Human Genet, Med Ctr, Nijmegen, Netherlands;Radboud Univ Nijmegen, Donders Inst Brain Cognit & Behav, Nijmegen, Netherlands
Indiana Univ Sch Med, Ctr Computat Biol & Bioinformat, Indianapolis, IN 46202 USA;Indiana Univ Sch Med, Ctr Neuroimaging Radiol & Imaging Sci, Indianapolis, IN 46202 USA;Indiana Univ Sch Med, Indiana Alzheimer Dis Ctr, Indianapolis, IN 46202 USA
Mirza-Schreiber, Nazanin (författare)
Max Planck Inst Psychiat, Munich, Germany;German Res Ctr Environm Hlth, Inst Neurogen, Helmholtz Zentrum Munchen, Neuherberg, Germany
Arfanakis, Konstantinos (författare)
Rush Univ, Med Ctr, Rush Alzheimers Dis Ctr, Chicago, IL 60612 USA;IIT, Dept Biomed Engn, Chicago, IL 60616 USA;Rush Univ, Med Ctr, Dept Diagnost Radiol & Nucl Med, Chicago, IL 60612 USA
Becker, Diane M. (författare)
Johns Hopkins Univ, Sch Med, Dept Med, GeneSTAR Res Program, Baltimore, MD 21205 USA
Ames, David (författare)
Univ Melbourne, Acad Unit Psychiat Old Age, Melbourne, Vic, Australia;Royal Melbourne Hosp, Natl Ageing Res Inst, Melbourne, Vic, Australia
Goldman, Aaron L. (författare)
Lieber Inst Brain Dev, Baltimore, MD USA
Lee, Phil H. (författare)
Massachusetts Gen Hosp, Dept Psychiat, Boston, MA 02114 USA;Harvard Med Sch, Boston, MA 02115 USA;Harvard Med Sch, Lurie Ctr Autism, Massachusetts Gen Hosp, Lexington, MA USA;Massachusetts Gen Hosp, Psychiat & Neurodev Genet Unit, Ctr Genom Med, Boston, MA 02114 USA;Broad Inst MIT & Harvard, Stanley Ctr Psychiat Res, Boston, MA USA
Univ Edinburgh, Brain Res Imaging Ctr, Edinburgh, Midlothian, Scotland;Lagos State Univ, Dept Comp Sci, Ojo, Nigeria
Schmidt, Helena (författare)
Med Univ Graz, Gottfried Schatz Res Ctr Cell Signaling Metab & A, Res Unit Genet Epidemiol, Graz, Austria
Strike, Lachlan T. (författare)
QIMR Berghofer Med Res Inst, Brisbane, Qld, Australia;Univ Queensland, Queensland Brain Inst, Brisbane, Qld, Australia
Cheng, Ching-Yu (författare)
Singapore Natl Eye Ctr, Singapore Eye Res Inst, Singapore, Singapore;Duke NUS Med Sch, Ophthalmol & Visual Sci Acad Clin Program Eye ACP, Singapore, Singapore
Risacher, Shannon L. (författare)
Indiana Univ Sch Med, Ctr Neuroimaging Radiol & Imaging Sci, Indianapolis, IN 46202 USA;Indiana Univ Sch Med, Indiana Alzheimer Dis Ctr, Indianapolis, IN 46202 USA
Puetz, Benno (författare)
Max Planck Inst Psychiat, Munich, Germany
Fleischman, Debra A. (författare)
Rush Univ, Med Ctr, Rush Alzheimers Dis Ctr, Chicago, IL 60612 USA;Rush Univ, Med Ctr, Dept Neurol Sci, Chicago, IL 60612 USA;Rush Univ, Med Ctr, Dept Behav Sci, Chicago, IL 60612 USA
Assareh, Amelia A. (författare)
Univ New South Wales, Ctr Hlth Brain Ageing, Sch Psychiat, Sydney, NSW, Australia
Univ Calif San Diego, Ctr Multimodal Imaging & Genet, San Diego, CA 92103 USA;Univ Calif San Diego, Dept Cognit Sci, San Diego, CA 92103 USA;Univ Calif San Diego, Dept Neurosci, San Diego, CA 92103 USA;Univ Calif San Diego, Dept Psychiat, San Diego, CA 92103 USA;Univ Calif San Diego, Dept Radiol, San Diego, CA 92103 USA
Cichon, Sven (författare)
Univ Basel, Dept Biomed, Div Med Genet, Basel, Switzerland;Univ Bonn, Inst Human Genet, Bonn, Germany;Res Ctr Julich, Inst Neurosci & Med Struct & Funct Org Brain INM, Julich, Germany
Univ New Mexico, Dept ECE, Albuquerque, NM 87131 USA;Mind Res Network, Albuquerque, NM USA;LBERI, Albuquerque, NM USA;Georgia State Univ, Triinst Ctr Translat Res Neuroimaging & Data Sci, Atlanta, GA 30303 USA
Massachusetts Gen Hosp, Dept Psychiat, Boston, MA 02114 USA;Massachusetts Gen Hosp, Martinos Ctr Biomed Imaging, Charlestown, MA USA;Harvard Med Sch, Boston, MA 02115 USA
Bulayeva, Kazima B. (författare)
Dagestan State Univ, Dept Evolut & Genet, Makhachkala, Russia
Bernard, Manon (författare)
Univ Toronto, Lospital Sick Children, Toronto, ON, Canada
German Ctr Neurodegenerat Dis, Greifswald, Germany;Univ Med Greifswald, Inst Community Med, Sect Epidemiol Hlth Care & Community Hlth, Greifswald, Germany
Westlye, Lars T. (författare)
Oslo Univ Hosp, Div Mental Hlth & Addict, CoE NORMENT, Oslo, Norway;Univ Oslo, Inst Clin Med, CoE NORMENT, Oslo, Norway
Univ Iowa, Dept Psychiat, Carver Coll Med, Iowa City, IA 52242 USA
Ching, Christopher R. K. (författare)
Univ Southern Calif, Keck Sch Med, USC Mark & Mary Stevens Neuroimaging & Informat I, Imaging Genet Ctr, Los Angeles, CA USA;UCLA, Sch Med, Interdept Neurosci Grad Program, Los Angeles, CA USA
Univ Washington, Dept Med, Cardiovasc Hlth Res Unit, Seattle, WA USA;Kaiser Permanent Washington Hlth Res Inst, Seattle, WA USA;Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA;Univ Washington, Dept Hlth Serv, Seattle, WA 98195 USA
Kings Coll London, Biomed Res Unit Dementia, London, England;Kings Coll London, Inst Psychiat, Dept Neuroimaging, London, England;Karolinska Inst, Dept Neurobiol Care Sci & Soc, Div Clin Geriatr, Stockholm, Sweden
Meyer-Lindenberg, Andreas (författare)
Heidelberg Univ, Med Fac Mannheim, Cent Inst Mental Hlth, Mannheim, Germany
Univ Cape Town, Dept Psychiat & Mental Hlth, Cape Town, South Africa;South African Med Res Council, Unit Risk & Resilience Mental Disorders, Cape Town, South Africa
Greve, Douglas N. (författare)
Massachusetts Gen Hosp, Martinos Ctr Biomed Imaging, Charlestown, MA USA;Harvard Med Sch, Massachusetts Gen Hosp, Dept Radiol, Boston, MA 02115 USA
Massachusetts Gen Hosp, Dept Psychiat, Boston, MA 02114 USA;Harvard Med Sch, Boston, MA 02115 USA;Massachusetts Gen Hosp, Psychiat & Neurodev Genet Unit, Ctr Genom Med, Boston, MA 02114 USA;Broad Inst MIT & Harvard, Stanley Ctr Psychiat Res, Boston, MA USA
Univ Edinburgh, Royal Edinburgh Hosp, Div Psychiat, Edinburgh, Midlothian, Scotland
Paus, Tomas (författare)
Holland Bloorview Kids Rehabil Hosp, Bloorview Res Inst, Toronto, ON, Canada;Univ Toronto, Dept Psychol, Toronto, ON, Canada;Univ Toronto, Dept Psychiat, Toronto, ON, Canada
Lemaitre, Herve (författare)
Paris Saclay Univ, INSERM, Res Unit Neuroimaging & Psychiat 1000, Gif Sur Yvette, France;Paris Descartes Univ, DIGITEO Labs, Gif Sur Yvette, France
Schroeter, Matthias L. (författare)
Univ Leipzig, LIFE Leipzig Res Ctr Civilizat Dis, Leipzig, Germany;Max Planck Inst Human Cognit & Brain Sci, Dept Neurol, Leipzig, Germany;Univ Clin Leipzig, Clin Cognit Neurol, Leipzig, Germany
Mazoyer, Bernard (författare)
Univ Bordeaux, Neurodegeneratives Dis Inst, CNRS UMR 5293, Bordeaux, France
Andreassen, Ole A. (författare)
Oslo Univ Hosp, Div Mental Hlth & Addict, CoE NORMENT, Oslo, Norway;Univ Oslo, Inst Clin Med, CoE NORMENT, Oslo, Norway
Holsboer, Florian (författare)
Max Planck Inst Psychiat, Munich, Germany;HMNC Brain Hlth, Munich, Germany
Depondt, Chantal (författare)
Univ Libre Bruxelles, Dept Neurol, Hop Erasme, Brussels, Belgium
Mind Res Network, Albuquerque, NM USA;LBERI, Albuquerque, NM USA;Georgia State Univ, Triinst Ctr Translat Res Neuroimaging & Data Sci, Atlanta, GA 30303 USA;Georgia State Univ, Dept Psychol, Univ Plaza, Atlanta, GA 30303 USA
Pausova, Zdenka (författare)
Univ Toronto, Lospital Sick Children, Toronto, ON, Canada
Univ Calif San Francisco, Ctr Imaging Neurodegenerat Dis, San Francisco VA Med Ctr, San Francisco, CA 94143 USA;Univ Calif San Francisco, Dept Radiol & Biomed Imaging, San Francisco, CA 94143 USA
Walter, Henrik (författare)
Freie Univ Berliepartment Psychiat & Psychotherap, Div Mind & Brain Res D, Berlin, Germany;Charite Univ Med Berlin, Berlin, Germany;Humboldt Univ, Berlin, Germany;Berlin Inst Hlth, Berlin, Germany
Hoekstra, Pieter J. (författare)
Univ Groningen, Univ Med Ctr Groningen, Dept Psychiat, Groningen, Netherlands
Nyquist, Paul A. (författare)
Johns Hopkins Univ, Sch Med, Dept Med, GeneSTAR Res Program, Baltimore, MD 21205 USA
Franke, Barbara (författare)
Radboud Univ Nijmegen, Dept Human Genet, Med Ctr, Nijmegen, Netherlands;Radboud Univ Nijmegen, Dept Psychiat, Med Ctr, Nijmegen, Netherlands;Radboud Univ Nijmegen, Donders Inst Brain Cognit & Behav, Nijmegen, Netherlands
Bennett, David A. (författare)
Rush Univ, Med Ctr, Rush Alzheimers Dis Ctr, Chicago, IL 60612 USA;Rush Univ, Med Ctr, Dept Neurol Sci, Chicago, IL 60612 USA
Subcortical brain structures are integral to motion, consciousness, emotions and learning. We identified common genetic variation related to the volumes of the nucleus accumbens, amygdala, brainstem, caudate nucleus, globus pallidus, putamen and thalamus, using genome-wide association analyses in almost 40,000 individuals from CHARGE, ENIGMA and UK Biobank. We show that variability in subcortical volumes is heritable, and identify 48 significantly associated loci (40 novel at the time of analysis). Annotation of these loci by utilizing gene expression, methylation and neuropathological data identified 199 genes putatively implicated in neurodevelopment, synaptic signaling, axonal transport, apoptosis, inflammation/infection and susceptibility to neurological disorders. This set of genes is significantly enriched for Drosophila orthologs associated with neurodevelopmental phenotypes, suggesting evolutionarily conserved mechanisms. Our findings uncover novel biology and potential drug targets underlying brain development and disease.
Ämnesord
MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Basic Medicine (hsv//eng)