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Sökning: onr:"swepub:oai:DiVA.org:uu-399003" > Peritoneal mesothel...

Peritoneal mesothelioma in Sweden : A population-based study

Cashin, Peter, 1984- (författare)
Uppsala universitet,Gastrointestinalkirurgi
Palmer, Gabriella Jansson (författare)
Karolinska Inst, Dept Mol Med & Surg, Stockholm, Sweden
Asplund, Dan (författare)
University of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för kirurgi,Institute of Clinical Sciences, Department of Surgery,Sahlgrenska University Hospital
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Graf, Wilhelm (författare)
Uppsala University,Uppsala universitet,Gastrointestinalkirurgi
Syk, Ingvar (författare)
Lund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups,Skåne University Hospital
Syk, I. (författare)
Graf, W. (författare)
Cashin, P. H. (författare)
Jansson Palmer, G. (författare)
Cashin, Peter H. (författare)
Uppsala University
Jansson Palmer, Gabriella (författare)
Karolinska Institutet
Syk, I (författare)
Graf, W (författare)
Asplund, D (författare)
Palmer, GJ (författare)
Karolinska Institutet
Cashin, PH (författare)
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Wiley-Blackwell, 2019
2019
Engelska.
Ingår i: ; 8:14, s. 6468-6475
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • The study aim was to report survival and morbidity of all patients in Sweden with peritoneal mesothelioma treated with cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) as well as investigate whether the survival has increased on a population level since this treatment was nationalized 2011. Study data were collected from the Swedish HIPEC registry and the Swedish National Cancer Registry. All patients with peritoneal mesothelioma scheduled for CRS/HIPEC treatment in Sweden January 2011 to March 2018 were retrieved from the Swedish HIPEC registry. Clinicopathological and survival data were collected. For population-level analysis, all patients with diffuse malignant peritoneal mesothelioma (DMPM) were identified from the Swedish National Cancer Registry and data were retrieved from two separate 5-year time periods: 1999-2003 and 2011-2015. Thirty-two patients were accepted for CRS/HIPEC. Four were open/close cases. Two-year survival rate was 84% or 59% when excluding borderline peritoneal mesotheliomas (n = 17). Median overall survival was not reached. Grade III-IV Clavien-Dindo events occurred in 22% with no mortality. From the national cancer registry, 102 DMPM cases were retrieved: 40 cases between 1999 and 2003, and 62 cases between 2011 and 2015 (corresponding to an increase from 0.9 to 1.24/million/year, P = .04). Six patients (10%) received CRS/HIPEC in the second period. Median OS increased between periods from 7 to 15 months and 5-year survival from 14% to 29% (P = .03). Peritoneal mesothelioma of both borderline and DMPM subtypes undergoing CRS/HIPEC have good long-term survival. The incidence of DMPM in Sweden has increased. Overall survival has increased alongside the introduction of CRS/HIPEC, which may be a contributing factor.

Ämnesord

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Surgery (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Kirurgi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine (hsv//eng)

Nyckelord

cytoreductive surgery
hyperthermic intraperitoneal chemotherapy
Peritoneal mesothelioma
peritoneal metastases
population-based study
cytoreductive surgery

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