SwePub
Sök i LIBRIS databas

  Utökad sökning

onr:"swepub:oai:DiVA.org:uu-407324"
 

Sökning: onr:"swepub:oai:DiVA.org:uu-407324" > Individual Patient ...

Individual Patient Data Pooled Analysis of Randomized Trials of Bivalirudin versus Heparin in Acute Myocardial Infarction : Rationale and Methodology

Bikdeli, Behnood (författare)
Columbia Univ, Dept Med, NewYork Presbyterian Hosp, Med Ctr,Div Cardiol, New York, NY USA;Yale Univ, Yale Sch Med, Ctr Outcomes Res & Evaluat, New Haven, CT USA;Cardiovasc Res Fdn, Clin Trials Ctr, New York, NY 10019 USA,New York Presbyterian Hospital/Columbia University Medical Center,Yale University,Cardiovascular Research Foundation, New York
McAndrew, Thomas (författare)
Cardiovasc Res Fdn, Clin Trials Ctr, New York, NY 10019 USA,Cardiovascular Research Foundation, New York
Crowley, Aaron (författare)
Cardiovasc Res Fdn, Clin Trials Ctr, New York, NY 10019 USA,Cardiovascular Research Foundation, New York
visa fler...
Chen, Shmuel (författare)
Columbia Univ, Dept Med, NewYork Presbyterian Hosp, Med Ctr,Div Cardiol, New York, NY USA;Cardiovasc Res Fdn, Clin Trials Ctr, New York, NY 10019 USA,New York Presbyterian Hospital/Columbia University Medical Center,Cardiovascular Research Foundation, New York
Mehdipoor, Ghazaleh (författare)
Cardiovasc Res Fdn, Clin Trials Ctr, New York, NY 10019 USA,Cardiovascular Research Foundation, New York
Redfors, Bjorn (författare)
Columbia Univ, Dept Med, NewYork Presbyterian Hosp, Med Ctr,Div Cardiol, New York, NY USA;Cardiovasc Res Fdn, Clin Trials Ctr, New York, NY 10019 USA;Sahlgrens Univ Hosp, Dept Cardiol, Gothenburg, Sweden
Liu, Yangbo (författare)
Cardiovasc Res Fdn, Clin Trials Ctr, New York, NY 10019 USA,Cardiovascular Research Foundation, New York
Zhang, Zixuan (författare)
Cardiovasc Res Fdn, Clin Trials Ctr, New York, NY 10019 USA,Cardiovascular Research Foundation, New York
Liu, Mengdan (författare)
Cardiovasc Res Fdn, Clin Trials Ctr, New York, NY 10019 USA,Cardiovascular Research Foundation, New York
Zhang, Yiran (författare)
Cardiovasc Res Fdn, Clin Trials Ctr, New York, NY 10019 USA,Cardiovascular Research Foundation, New York
Francese, Dominic P. (författare)
Cardiovasc Res Fdn, Clin Trials Ctr, New York, NY 10019 USA,Cardiovascular Research Foundation, New York
Erlinge, David (författare)
Lund University,Lunds universitet,Molekylär kardiologi,Forskargrupper vid Lunds universitet,Molecular Cardiology,Lund University Research Groups
James, Stefan, 1964- (författare)
Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR)
Han, Yaling (författare)
Gen Hosp Northern Theater Command, Dept Cardiol, Shenyang, Peoples R China,Shenyang General Hospital of PLA
Li, Yi (författare)
Gen Hosp Northern Theater Command, Dept Cardiol, Shenyang, Peoples R China,Shenyang General Hospital of PLA
Kastrati, Adnan (författare)
Tech Univ, Deutsch Herzzentrum Munchen, Dept Cardiol, Munich, Germany,German Heart Centre, Munich,Technical University of Munich
Schuepke, Stefanie (författare)
Tech Univ, Deutsch Herzzentrum Munchen, Dept Cardiol, Munich, Germany
Stables, Rod H. (författare)
Liverpool Heart & Chest Hosp, Liverpool, Merseyside, England;Univ Liverpool, Liverpool, Merseyside, England,Liverpool Heart and Chest Hospital,University of Liverpool
Shahzad, Adeel (författare)
Liverpool Heart & Chest Hosp, Liverpool, Merseyside, England,Liverpool Heart and Chest Hospital
Steg, Philippe Gabriel (författare)
Hop Bichat Claude Bernard, Paris, France;Royal Brompton Hosp, Imperial Coll, London, England,Royal Brompton Hospital,Hopital Bichat-Claude-Bernard AP-HP
Goldstein, Patrick (författare)
Lille Univ Hosp, Lille, France,Lille University Hospital
Frigoli, Enrico (författare)
Univ Bern, Bern Univ Hosp, Dept Cardiol, Bern, Switzerland,University of Bern,Bern University Hospital
Mehran, Roxana (författare)
Cardiovasc Res Fdn, Clin Trials Ctr, New York, NY 10019 USA;Icahn Sch Med Mt Sinai, Zena & Michael A Wiener Cardiovasc Inst, New York, NY 10029 USA,Cardiovascular Research Foundation, New York,Icahn School of Medicine at Mount Sinai
Valgimigli, Marco (författare)
Univ Bern, Bern Univ Hosp, Dept Cardiol, Bern, Switzerland,University of Bern,Bern University Hospital
Stone, Gregg W. (författare)
Cardiovasc Res Fdn, Clin Trials Ctr, New York, NY 10019 USA;Icahn Sch Med Mt Sinai, Zena & Michael A Wiener Cardiovasc Inst, New York, NY 10029 USA,Cardiovascular Research Foundation, New York,Icahn School of Medicine at Mount Sinai
Francese, Dominic P (författare)
James, Stefan K (författare)
Stone, Gregg W (författare)
Redfors, Björn (författare)
Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine,Sahlgrenska University Hospital,New York Presbyterian Hospital/Columbia University Medical Center,Cardiovascular Research Foundation, New York
Schupke, Sefanie (författare)
Liu, Yanbgo (författare)
Stables, Rod H (författare)
Kastarti, Adnan (författare)
Bikdeli, Benhnood (författare)
James, Stefan K. (författare)
Uppsala University
Schüpke, Stefanie (författare)
German Heart Centre, Munich,Technical University of Munich
visa färre...
 (creator_code:org_t)
 
visa fler...
 
visa färre...
Schattauer GmbH, 2020
2020
Engelska.
Ingår i: Thrombosis and Haemostasis. - : Schattauer GmbH. - 0340-6245. ; 120:2, s. 348-361
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Background Individual randomized controlled trials (RCTs) of periprocedural anticoagulation with bivalirudin versus heparin during percutaneous coronary intervention (PCI) have reported conflicting results. Study-level meta-analyses lack granularity to adjust for confounders, explore heterogeneity, or identify subgroups that may particularly benefit or be harmed.Objective To overcome these limitations, we sought to develop an individual patient-data pooled database of RCTs comparing bivalirudin versus heparin.Methods We conducted a systematic review to identify RCTs in which ≥1,000 patients with acute myocardial infarction (AMI) undergoing PCI were randomized to bivalirudin versus heparin.Results From 738 identified studies, 8 RCTs met the prespecified criteria. The principal investigators of each study agreed to provide patient-level data. The data were pooled and checked for accuracy against trial publications, with discrepancies addressed by consulting with the trialists. Consensus-based definitions were created to resolve differing antithrombotic, procedural, and outcome definitions. The project required 3.5 years to complete, and the final database includes 27,409 patients (13,346 randomized to bivalirudin and 14,063 randomized to heparin).Conclusion We have created a large individual patient database of bivalirudin versus heparin RCTs in patients with AMI undergoing PCI. This endeavor may help identify the optimal periprocedural anticoagulation regimen for patient groups with different relative risks of adverse ischemic versus bleeding events, including those with ST-segment and non-ST-segment elevation MI, radial versus femoral access, use of a prolonged bivalirudin infusion or glycoprotein inhibitors, and others. Adherence to standardized techniques and rigorous validation processes should increase confidence in the accuracy and robustness of the results..

Ämnesord

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Kardiologi (hsv//swe)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine (hsv//eng)

Nyckelord

bivalirudin
heparin
pooled analysis
percutaneous coronary intervention
acute myocardial infarction

Publikations- och innehållstyp

ref (ämneskategori)
art (ämneskategori)

Hitta via bibliotek

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy