Brown Univ, Sch Publ Hlth, Dept Hlth Serv Policy & Practice, Providence, RI 02912 USA;Brown Univ, Sch Publ Hlth, Ctr Gerontol & Healthcare Res, Providence, RI 02912 USA
Teras, Lauren R. (författare)
Amer Canc Soc, Epidemiol Res Program, Atlanta, GA 30329 USA
Monnereau, Alain (författare)
INSERM, Epidemiol Childhood & Adolescent Canc Grp, Ctr Res Epidemiol & Stat Sorbonne Paris Cite CRES, Paris, France;Univ Paris 05, Paris, France;Inst Bergonie, Registre Hemopathies Malignes Gironde, Bordeaux, France
Wong Doo, Nicole (författare)
Canc Council Victoria, Canc Epidemiol & Intelligence Div, Melbourne, Vic, Australia
Machiela, Mitchell J. (författare)
NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA
Skibola, Christine F. (författare)
Emory Univ, Sch Med, Dept Hematol & Med Oncol, Atlanta, GA USA
Slager, Susan L. (författare)
Mayo Clin, Dept Hlth Sci Res, Rochester, MN USA
Salles, Gilles (författare)
Hosp Civils Lyon, Dept Hematol, Lyon, France;Univ Lyon 1, Dept Hematol, Lyon, France;Inst Natl Sante & Rech Med UMR1052 Pierre Benite, Canc Res Ctr Lyon, Equipe Expt & Clin Models Lymphomagenesis, Lyon, France
Camp, Nicola J. (författare)
Univ Utah, Sch Med, Dept Internal Med, Div Hematol & Hematol Malignancies, Salt Lake City, UT USA;Univ Utah, Sch Med, Huntsman Canc Inst, Salt Lake City, UT USA
Bracci, Paige M. (författare)
Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA USA
Nieters, Alexandra (författare)
Univ Med Ctr Freiburg, Ctr Chron Immunodeficiency, Freiburg, Germany
Vermeulen, Roel C. H. (författare)
Univ Utrecht, Inst Risk Assessment Sci, Div Environm Epidemiol, Utrecht, Netherlands;Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands
Vijai, Joseph (författare)
Mem Sloan Kettering Canc Ctr, Dept Med, Clin Genet Serv, 1275 York Ave, New York, NY 10021 USA
Smedby, Karin E. (författare)
Karolinska Inst, Dept Med, Solna, Solna, Sweden;Karolinska Univ Hosp, Hematol Ctr, Stockholm, Sweden
Zhang, Yawei (författare)
Yale Sch Publ Hlth, Dept Environm Hlth Sci, New Haven, CT USA
Vajdic, Claire M. (författare)
Univ New South Wales, Ctr Big Data Res Hlth, Sydney, NSW, Australia
Cozen, Wendy (författare)
Univ Southern Calif, Keck Sch Med, Dept Prevent Med, Los Angeles, CA 90007 USA;Univ Southern Calif, Keck Sch Med, Norris Comprehens Canc Ctr, Los Angeles, CA 90007 USA
Spinelli, John J. (författare)
BC Canc, Canc Control Res, Vancouver, BC, Canada;Univ British Columbia, Sch Populat & Publ Hlth, Vancouver, BC, Canada
Canc Council Victoria, Canc Epidemiol & Intelligence Div, Melbourne, Vic, Australia;Univ Melbourne, Melbourne Sch Populat & Global Hlth, Ctr Epidemiol & Biostat, Melbourne, Vic, Australia
Link, Brian K. (författare)
Univ Iowa, Carver Coll Med, Dept Internal Med, Iowa City, IA USA
Clavel, Jacqueline (författare)
INSERM, Epidemiol Childhood & Adolescent Canc Grp, Ctr Res Epidemiol & Stat Sorbonne Paris Cite CRES, Paris, France;Univ Paris 05, Paris, France
Arslan, Alan A. (författare)
NYU, Sch Med, Dept Obstet & Gynecol, New York, NY USA;NYU, Sch Med, Dept Environm Med, New York, NY USA;NYU, Langone Med Ctr, Perlmutter Canc Ctr, New York, NY USA
Purdue, Mark P. (författare)
Ontario Hlth Study, Toronto, ON, Canada
Tinker, Lesley F. (författare)
Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA
Albanes, Demetrius (författare)
NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA
Amer Canc Soc, Epidemiol Res Program, Atlanta, GA 30329 USA
Ghesquieres, Herve (författare)
Inst Natl Sante & Rech Med UMR1052 Pierre Benite, Canc Res Ctr Lyon, Equipe Expt & Clin Models Lymphomagenesis, Lyon, France;Ctr Leon Berard, Dept Hematol, Lyon, France
Glenn, Martha (författare)
Huntsman Canc Inst, Dept Internal Med, Salt Lake City, UT USA
Glimelius, Bengt (författare)
Uppsala universitet,Experimentell och klinisk onkologi
Jackson, Rebecca D. (författare)
Ohio State Univ, Div Endocrinol Diabet & Metab, Columbus, OH USA
Lan, Qing (författare)
NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA
Liebow, Mark (författare)
Mayo Clin, Coll Med & Sci, Div Gen Internal Med, Rochester, MN USA
Although the evidence is not consistent, epidemiologic studies have suggested that taller adult height may be associated with an increased risk of some non-Hodgkin lymphoma (NHL) subtypes. Height is largely determined by genetic factors, but how these genetic factors may contribute to NHL risk is unknown. We investigated the relationship between genetic determinants of height and NHL risk using data from eight genome-wide association studies (GWAS) comprising 10,629 NHL cases, including 3,857 diffuse large B-cell lymphoma (DLBCL), 2,847 follicular lymphoma (FL), 3,100 chronic lymphocytic leukemia (CLL), and 825 marginal zone lymphoma (MZL) cases, and 9,505 controls of European ancestry. We evaluated genetically predicted height by constructing polygenic risk scores using 833 height-associated SNPs. We used logistic regression to estimate odds ratios (OR) and 95% confidence intervals (CI) for association between genetically determined height and the risk of four NHL subtypes in each GWAS and then used fixed-effect meta-analysis to combine subtype results across studies. We found suggestive evidence between taller genetically determined height and increased CLL risk (OR = 1.08, 95% CI = 1.00-1.17, p = 0.049), which was slightly stronger among women (OR = 1.15, 95% CI: 1.01-1.31, p = 0.036). No significant associations were observed with DLBCL, FL, or MZL. Our findings suggest that there may be some shared genetic factors between CLL and height, but other endogenous or environmental factors may underlie reported epidemiologic height associations with other subtypes.
Ämnesord
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)