Antoni van Leeuwenhoek Hosp, Netherlands Canc Inst, Div Mol Pathol, Amsterdam, Netherlands.;Antoni van Leeuwenhoek Hosp, Netherlands Canc Inst, Div Mol Carcinogenesis, Amsterdam, Netherlands.
Keeman, Renske (författare)
Antoni van Leeuwenhoek Hosp, Netherlands Canc Inst, Div Mol Pathol, Amsterdam, Netherlands.
Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Oncol, Cambridge, England.;Cambridge Expt Canc Med Ctr, Cambridge, England.;Univ Cambridge NHS Fdn Hosp, Cambridge Breast Unit, Cambridge, England.;Univ Cambridge NHS Fdn Hosp, NIHR Cambridge Biomed Res Ctr, Cambridge, England.
Andrulis, Irene L. (författare)
Mt Sinai Hosp, Fred A Litwin Ctr Canc Genet, Lunenfeld Tanenbaum Res Inst, Toronto, ON, Canada.;Univ Toronto, Dept Mol Genet, Toronto, ON, Canada.
Anton-Culver, Hoda (författare)
Univ Calif Irvine, Dept Epidemiol, Genet Epidemiol Res Inst, Irvine, CA USA.
Arndt, Volker (författare)
German Canc Res Ctr, Div Clin Epidemiol & Aging Res, Heidelberg, Germany.
Auer, Paul L. (författare)
Fred Hutchinson Canc Res Ctr, Canc Prevent Program, 1124 Columbia St, Seattle, WA 98104 USA.;Univ Wisconsin, Zilber Sch Publ Hlth, Milwaukee, WI 53201 USA.
Beckmann, Matthias W. (författare)
Friedrich Alexander Univ Erlangen Nuremberg, Univ Hosp Erlangen, Comprehens Canc Ctr ER EMN, Dept Gynecol & Obstet, Erlangen, Germany.
Behrens, Sabine (författare)
German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Germany.
Benitez, Javier (författare)
Spanish Natl Canc Res Ctr CNIO, Human Canc Genet Programme, Madrid, Spain.;Biomed Network Rare Dis CIBERER, Madrid, Spain.
Cambridge Expt Canc Med Ctr, Cambridge, England.;Univ Cambridge NHS Fdn Hosp, Cambridge Breast Unit, Cambridge, England.;Univ Cambridge NHS Fdn Hosp, NIHR Cambridge Biomed Res Ctr, Cambridge, England.;Inst Canc Res, Sect Canc Genet, London, England.
Caldes, Trinidad (författare)
Hosp Cln San Carlos, Ctr Invest Biorned Red Canc CIBERONC, Inst Invest Sanitaria San Carlos IdISSC, Med Oncol Dept, Madrid, Spain.
Campa, Daniele (författare)
German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Germany.;Univ Pisa, Dept Biol, Pisa, Italy.
Canzian, Federico (författare)
German Canc Res Ctr, Mol Epidemiol Grp, C080, Heidelberg, Germany.
Carracedo, Angel (författare)
Galician Fdn Genom Med, Inst Invest Sanitaria Santiago Compostela IDIS, SERGAS, Genom Med Grp, Santiago De Compostela, Spain.;Univ Santiago Compostela, Ctr Invest Red Enfermedades Raras CIBERER, Santiago De Compostela, Spain.;King Abdulaziz Univ, Ctr Excellence Genom Med, Jeddah, Saudi Arabia.
Carter, Brian D. (författare)
Amer Canc Soc, Epidemiol Res Program, Atlanta, GA 30329 USA.
Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden.
Gago-Dominguez, Manuela (författare)
Galician Fdn Genom Med, Inst Invest Sanitaria Santiago Compostela IDIS, SERGAS, Genom Med Grp, Santiago De Compostela, Spain.;Univ Calif San Diego, Moores Canc Ctr, La Jolla, CA 92093 USA.
NCI, Radiat Epidemiol Branch, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA.
Knight, Julia A. (författare)
Prosserman Ctr Populat Hlth Res, Lunenfeld Tanenbaum Res Inst, Sinai Hlth Syst, Toronto, ON, Canada.;Univ Toronto, Dalla Lana Sch Publ Hlth, Div Epidemiol, Toronto, ON, Canada.
Inst Canc Res, Div Genet & Epidemiol, London, England.;Inst Canc Res, Div Breast Canc Res, London, England.
Talhouk, Aline (författare)
BC Canc Agcy, Vancouver Gen Hosp, British Columbias Ovarian Canc Res OVCARE Program, Vancouver, BC, Canada.;Univ British Columbia, Vancouver, BC, Canada.;Univ British Columbia, Dept Pathol & Lab Med, Vancouver, BC, Canada.;Univ British Columbia, Dept Obstet & Gynaecol, Vancouver, BC, Canada.
Tamimi, Rulla M. (författare)
Harvard Med Sch, Dept Med, Brigham & Womens Hosp, Channing Div Network Med, Boston, MA 02115 USA.;Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA.;Harvard TH Chan Sch Publ Hlth, Program Genet Epidemiol & Stat Genet, Boston, MA USA.
Tapper, William J. (författare)
Univ Southampton, Fac Med, Southampton, Hants, England.
Univ Manchester, Manchester Acad Hlth Sci Ctr, Fac Biol, Sch Biol Sci, Manchester, Lancs, England.;Cent Manchester Univ Hosp NHS Fdn Trust, St Marys Hosp, Manchester Acad Hlth Sci Ctr, Manchester Ctr Genom Med, Manchester, Lancs, England.
Wendt, Camilla (författare)
Karolinska Inst, Dept Clin Sci & Educ, Sodersjukhuset, Stockholm, Sweden.
Whittemore, Alice S. (författare)
Stanford Univ, Sch Med, Dept Hlth Res & Policy Epidemiol, Stanford, CA 94305 USA.;Stanford Univ, Sch Med, Dept Biomed Data Sci, Stanford, CA 94305 USA.
Willett, Walter (författare)
Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA.;Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA USA.;Brigham & Womens Hosp, Channing Div Network Med, 75 Francis St, Boston, MA 02115 USA.;Harvard Med Sch, Boston, MA 02115 USA.
Winqvist, Robert (författare)
Univ Oulu, Bioctr Oulu, Canc & Translat Med Res Unit, Lab Canc Genet & Tumour Biol, Oulu, Finland.;Northern Finland Lab Ctr Oulu, Lab Canc Genet & Tumour Biol, Oulu, Finland.
Wolk, Alicja (författare)
Karolinska Inst, Dept Environm Med, Div Nutr Epidemiol, Stockholm, Sweden.
Yang, Xiaohong R. (författare)
NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA.
Zhang, Yan (författare)
German Canc Res Ctr, Div Clin Epidemiol & Aging Res, Heidelberg, Germany.;German Canc Consortium DKTK, German Canc Res Ctr DKFZ, Heidelberg, Germany.
Friedrich Alexander Univ Erlangen Nuremberg, Univ Hosp Erlangen, Comprehens Canc Ctr ER EMN, Dept Gynecol & Obstet, Erlangen, Germany.;Univ Calif Los Angeles, David Geffen Sch Med, Dept Med Div Hematol & Oncol, Los Angeles, CA 90095 USA.
Antoni van Leeuwenhoek Hosp, Netherlands Canc Inst, Div Mol Pathol, Amsterdam, Netherlands.;Antoni van Leeuwenhoek Hosp, Div Psychosocial Res & Epidemiol, Netherlands Canc Inst, Amsterdam, Netherlands.
Schmidt, Marjanka K (författare)
Antoni Van Leeuwenhoek Hospital,Netherlands Cancer Institute
Olsson, Håkan (författare)
Lund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Lunds Melanomstudiegrupp,Forskargrupper vid Lunds universitet,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund Melanoma Study Group,Lund University Research Groups
Krüger, Ute (författare)
Lund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine
BACKGROUND: We examined the associations between germline variants and breast cancer mortality using a large meta-analysis of women of European ancestry. METHODS: Meta-analyses included summary estimates based on Cox models of twelve datasets using similar to 10.4 million variants for 96,661 women with breast cancer and 7697 events (breast cancer-specific deaths). Oestrogen receptor (ER)-specific analyses were based on 64,171 ER-positive (4116) and 16,172 ER-negative (2125) patients. We evaluated the probability of a signal to be a true positive using the Bayesian false discovery probability (BFDP). RESULTS: We did not find any variant associated with breast cancer-specific mortality at P<5 x 10(-8). For ER-positive disease, the most significantly associated variant was chr7:rs4717568 (BFDP = 7%, P = 1.28 x 10(-7), hazard ratio [HR] = 0.88, 95% confidence interval [ CI] = 0.84-0.92); the closest gene is AUTS2. For ER-negative disease, the most significant variant was chr7: rs67918676 (BFDP = 11%, P = 1.38 x 10(-7), HR = 1.27, 95% CI = 1.16-1.39); located within a long intergenic non-coding RNA gene (AC004009.3), close to the HOXA gene cluster. CONCLUSIONS: We uncovered germline variants on chromosome 7 at BFDP <15% close to genes for which there is biological evidence related to breast cancer outcome. However, the paucity of variants associated with mortality at genome-wide significance underpins the challenge in providing genetic-based individualised prognostic information for breast cancer patients.
Ämnesord
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper (hsv//swe)
MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Basic Medicine (hsv//eng)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)