Genome-Wide Meta-Analyses of Breast, Ovarian, and Prostate Cancer Association Studies Identify Multiple New Susceptibility Loci Shared by at Least Two Cancer Types
Helsinki Univ Hosp, Dept Oncol, Helsinki, Finland.;Univ Helsinki, Helsinki, Finland.
Phelan, Catherine (författare)
H Lee Moffitt Canc Ctr & Res Inst, Dept Canc Epidemiol, Tampa, FL USA.
McLean, Catriona (författare)
Alfred Hosp, Anat Pathol, Melbourne, Vic, Australia.
Pearce, Celeste Leigh (författare)
Univ Michigan, Sch Publ Hlth, Dept Epidemiol, Ann Arbor, MI 48109 USA.
Vachon, Celine (författare)
Mayo Clin, Div Epidemiol, Dept Hlth Sci Res, Rochester, MN USA.
Cybulski, Cezary (författare)
Pomeranian Med Univ, Dept Genet & Pathol, Int Hereditary Canc Ctr, Szczecin, Poland.
Slavov, Chavdar (författare)
Med Univ, Alexandrovska Univ Hosp, Dept Urol, Sofia, Bulgaria.
Stegmaier, Christa (författare)
Saarland Canc Registry, Saarbrucken, Germany.
Maier, Christiane (författare)
Univ Hosp Ulm, Dept Urol, Ulm, Germany.
Ambrosone, Christine B. (författare)
Roswell Pk Canc Inst, Buffalo, NY 14263 USA.
Hogdall, Claus K. (författare)
Univ Copenhagen, Dept Gynecol, Juliane Marie Ctr, Rigshosp, Copenhagen, Denmark.
Teerlink, Craig C. (författare)
Univ Utah, Sch Med, Dept Internal Med, Div Genet Epidemiol, Salt Lake City, UT USA.
Kang, Daehee (författare)
Seoul Natl Univ, Canc Res Inst, Seoul, South Korea.;Seoul Natl Univ, Coll Med, Dept Prevent Med, Seoul, South Korea.;Seoul Natl Univ, Coll Med, Dept Surg, Seoul, South Korea.
Kings Coll London, Guys Hosp, Res Oncol, London, England.
Bandera, Elisa V. (författare)
State Univ New Jersey, Rutgers Canc Inst New Jersey, Canc Prevent & Control Program, New Brunswick, NJ USA.
Poole, Elizabeth M. (författare)
Brigham & Womens Hosp, Channing Div Network Med, 75 Francis St, Boston, MA 02115 USA.;Harvard Med Sch, Boston, MA USA.;Harvard Sch Publ Hlth, Dept Epidemiol, Boston, MA USA.
Goode, Ellen L. (författare)
Mayo Clin, Div Epidemiol, Dept Hlth Sci Res, Rochester, MN USA.
Univ Pittsburgh, Sch Med, Dept Obstet Gynecol & Reprod Sci, Div Gynecol Oncol, Pittsburgh, PA USA.;Univ Pittsburgh, Grad Sch Publ Hlth, Dept Epidemiol, Pittsburgh, PA USA.;Magee Womens Res Inst, Womens Canc Res Program, Pittsburgh, PA USA.;Univ Pittsburgh, Inst Canc, Pittsburgh, PA USA.
Hamdy, Freddie C. (författare)
Univ Oxford, Nuffield Dept Surg Sci, Oxford, England.;Univ Oxford, John Radcliffe Hosp, Fac Med Sci, Oxford, England.
Wiklund, Fredrik (författare)
Karolinska Institutet,Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden.
Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden.
Brenner, Hermann (författare)
German Canc Res Ctr, Div Clin Epidemiol & Aging Res, Heidelberg, Germany.;German Canc Res Ctr, German Canc Consortium DKTK, Heidelberg, Germany.;Natl Ctr Tumor Dis NCT, Div Prevent Oncol, Heidelberg, Germany.;German Canc Res Ctr, Heidelberg, Germany.
Brauch, Hiltrud (författare)
German Canc Res Ctr, German Canc Consortium DKTK, Heidelberg, Germany.;Dr Margarete Fischer Bosch Inst Clin Pharmacol, Stuttgart, Germany.;Univ Tubingen, Tubingen, Germany.
Anton-Culver, Hoda (författare)
Univ Calif Irvine, Sch Med, Dept Epidemiol, UCI Ctr Canc Genet Res & Prevent, Irvine, CA 92717 USA.
Pomeranian Med Univ, Dept Genet & Pathol, Int Hereditary Canc Ctr, Szczecin, Poland.
Lubinski, Jan (författare)
Pomeranian Med Univ, Dept Genet & Pathol, Int Hereditary Canc Ctr, Szczecin, Poland.
Stanford, Janet L. (författare)
Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Program Epidemiol, 1124 Columbia St, Seattle, WA 98104 USA.;Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA.
Bentez, Javier (författare)
Spanish Natl Canc Res Ctr CNIO, Human Canc Genet Program, Madrid, Spain.;Spanish Natl Genotyping Ctr CEGEN, Madrid, Spain.
Doherty, Jennifer A. (författare)
Geisel Sch Med Dartmouth, Dept Epidemiol, Hanover, NH USA.
Permuth, Jennifer B. (författare)
H Lee Moffitt Canc Ctr & Res Inst, Dept Canc Epidemiol, Tampa, FL USA.
Chang-Claude, Jenny (författare)
German Canc Res Ctr, Div Canc Epidemiol, Heidelberg, Germany.
Donovan, Jenny L. (författare)
Univ Bristol, Sch Social & Community Med, Bristol, Avon, England.
Mt Sinai Hosp, Lunenfeld Tanenbaum Res Inst, Prosserman Ctr Hlth Res, Toronto, ON, Canada.;Univ Toronto, Dalla Lana Sch Publ Hlth, Div Epidemiol, Toronto, ON, Canada.
Univ Cambridge, Clin Gerontol Unit, Cambridge, England.
Matsuo, Keitaro (författare)
Kyushu Univ, Fac Med Sci, Dept Prevent Med, Nagoya, Aichi, Japan.
Muir, Kenneth (författare)
Univ Manchester, Inst Populat Hlth, Manchester, Lancs, England.;Univ Warwick, Warwick Med Sch, Coventry, W Midlands, England.
Offitt, Kenneth (författare)
Mem Sloan Kettering Canc Ctr, Clin Genet Res Lab, Dept Canc Biol & Genet, 1275 York Ave, New York, NY 10021 USA.;Mem Sloan Kettering Canc Ctr, Dept Med, Clin Genet Serv, 1275 York Ave, New York, NY 10021 USA.
Chen, Kexin (författare)
Tianjin Med Univ Canc Inst & Hosp, Natl Clin Res Ctr Canc, Key Lab Canc Prevent & Therapy, Dept Epidemiol & Biostat, Tianjin, Peoples R China.
Moysich, Kirsten B. (författare)
Roswell Pk Canc Inst, Dept Canc Prevent & Control, Buffalo, NY 14263 USA.
Cedars Sinai Med Ctr, Samuel Oschin Comprehens Canc Inst, Canc Prevent & Control, Los Angeles, CA 90048 USA.;Cedars Sinai Med Ctr, Dept Biomed Sci, Community & Populat Hlth Res Inst, Los Angeles, CA 90048 USA.
Schmidt, Marjanka K. (författare)
Antoni van Leeuwenhoek Hosp, Netherlands Canc Inst, Amsterdam, Netherlands.
Riggan, Marjorie (författare)
Duke Univ, Med Ctr, Dept Obstet & Gynecol, Durham, NC 27710 USA.
Aly, Markus (författare)
Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden.;Danderyd Hosp, Dept Clin Sci, Stockholm, Sweden.
Rossing, Mary Anne (författare)
Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Program Epidemiol, 1124 Columbia St, Seattle, WA 98104 USA.;Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA.
Mem Sloan Kettering Canc Ctr, Dept Epidemiol & Biostat, New York, NY 10021 USA.
McDonnell, Shannon K. (författare)
Mayo Clin, Rochester, MN USA.
Tworoger, Shelley S. (författare)
Brigham & Womens Hosp, Channing Div Network Med, 75 Francis St, Boston, MA 02115 USA.;Harvard Med Sch, Boston, MA USA.;Harvard Sch Publ Hlth, Dept Epidemiol, Boston, MA USA.
Lund University,Lunds universitet,Medicinsk onkologi,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumörmikromiljö,Institutionen för kliniska vetenskaper, Lund,Lunds Melanomstudiegrupp,Forskargrupper vid Lunds universitet,Medical oncology,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Tumor microenvironment,Department of Clinical Sciences, Lund,Lund Melanoma Study Group,Lund University Research Groups,Skåne University Hospital
Breast, ovarian, and prostate cancers are hormone-related and may have a shared genetic basis, but this has not been investigated systematically by genome-wide association (GWA) studies. Meta-analyses combining the largest GWA meta-analysis data sets for these cancers totaling 112,349 cases and 116,421 controls of European ancestry, all together and in pairs, identified at P < 10 -8 seven new cross-cancer loci: three associated with susceptibility to all three cancers (rs17041869/2q13/BCL2L11; rs7937840/11q12/INCENP; rs1469713/19p13/GATAD2A), two breast and ovarian cancer risk loci (rs200182588/9q31/SMC2; rs8037137/15q26/RCCD1), and two breast and prostate cancer risk loci (rs5013329/1p34/NSUN4; rs9375701/6q23/L3MBTL3). Index variants in five additional regions previously associated with only one cancer also showed clear association with a second cancer type. Cell-type-specific expression quantitative trait locus and enhancer-gene interaction annotations suggested target genes with potential cross-cancer roles at the new loci. Pathway analysis revealed significant enrichment of death receptor signaling genes near loci with P < 10(-5) in the three-cancer meta-analysis. SIGNIFICANCE: We demonstrate that combining large-scale GWA meta-analysis findings across cancer types can identify completely new risk loci common to breast, ovarian, and prostate cancers. We show that the identification of such cross-cancer risk loci has the potential to shed new light on the shared biology underlying these hormone-related cancers. (C) 2016 AACR.
Ämnesord
MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper (hsv//swe)
MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Basic Medicine (hsv//eng)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)