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Association between Class III Obesity (BMI of 40-59 kg/m(2)) and Mortality : A Pooled Analysis of 20 Prospective Studies

Kitahara, Cari M. (författare)
NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA.
Flint, Alan J. (författare)
Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA.;Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA.
de Gonzalez, Amy Berrington (författare)
NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA.
visa fler...
Bernstein, Leslie (författare)
City Hope Natl Med Ctr, Beckman Res Inst, Dept Populat Sci, Div Canc Etiol, Duarte, CA USA.
Brotzman, Michelle (författare)
WESTAT Corp, Rockville, MD 20850 USA.
MacInnis, Robert J. (författare)
Canc Council Victoria, Canc Epidemiol Ctr, Melbourne, Vic, Australia.;Univ Melbourne, Ctr Mol Environm Genet & Analyt Epidemiol, Melbourne, Vic, Australia.
Moore, Steven C. (författare)
NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA.
Robien, Kim (författare)
George Washington Univ, Dept Epidemiol & Biostat, Sch Publ Hlth & Hlth Serv, Washington, DC USA.
Rosenberg, Philip S. (författare)
NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA.
Singh, Pramil N. (författare)
Loma Linda Univ, Sch Publ Hlth, Ctr Hlth Res, Loma Linda, CA 92350 USA.
Weiderpass, Elisabete (författare)
Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden.;Univ Tromso, Fac Hlth Sci, Dept Community Med, Tromso, Norway.;Canc Registry Norway, Dept Res, Oslo, Norway.;Samfundet Folkhalsan, Helsinki, Finland.
Adami, Hans Olov (författare)
Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA.;Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden.
Anton-Culver, Hoda (författare)
Univ Calif Irvine, Sch Med, Dept Epidemiol, Irvine, CA 92717 USA.
Ballard-Barbash, Rachel (författare)
NCI, Div Canc Control & Populat Sci, Bethesda, MD 20892 USA.
Buring, Julie E. (författare)
Harvard Univ, Brigham & Womens Hosp, Sch Med, Div Prevent Med, Boston, MA 02115 USA.;Harvard Univ, Brigham & Womens Hosp, Sch Med, Div Aging, Boston, MA 02115 USA.
Freedman, D. Michal (författare)
NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA.
Fraser, Gary E. (författare)
Loma Linda Univ, Sch Publ Hlth, Dept Epidemiol Biostat & Populat Med, Loma Linda, CA 92350 USA.
Freeman, Laura E. Beane (författare)
NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA.
Gapstur, Susan M. (författare)
Amer Canc Soc, Epidemiol Res Program, Atlanta, GA 30329 USA.
Gaziano, John Michael (författare)
Harvard Univ, Brigham & Womens Hosp, Sch Med, Div Prevent Med, Boston, MA 02115 USA.;Harvard Univ, Brigham & Womens Hosp, Sch Med, Div Aging, Boston, MA 02115 USA.;VA Boston Healthcare Syst, Geriatr Res Educ & Clin Ctr, Massachusetts Vet Epidemiol Res & Informat Ctr, Boston, MA USA.
Giles, Graham G. (författare)
Canc Council Victoria, Canc Epidemiol Ctr, Melbourne, Vic, Australia.;Univ Melbourne, Ctr Mol Environm Genet & Analyt Epidemiol, Melbourne, Vic, Australia.
Hakansson, Niclas (författare)
Karolinska Inst, Natl Inst Environm Med, Div Nutr Epidemiol, Stockholm, Sweden.
Hoppin, Jane A. (författare)
NIEHS, Epidemiol Branch, NIH, US Dept HHS, Res Triangle Pk, NC 27709 USA.
Hu, Frank B. (författare)
Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA.;Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA.
Koenig, Karen (författare)
NYU, Sch Med, Dept Populat Hlth, Div Epidemiol, New York, NY USA.;NYU, Sch Med, Inst Canc, New York, NY USA.
Linet, Martha S. (författare)
NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA.
Park, Yikyung (författare)
NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA.
Patel, Alpa V. (författare)
Amer Canc Soc, Epidemiol Res Program, Atlanta, GA 30329 USA.
Purdue, Mark P. (författare)
NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA.
Schairer, Catherine (författare)
NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA.
Sesso, Howard D. (författare)
Harvard Univ, Brigham & Womens Hosp, Sch Med, Div Prevent Med, Boston, MA 02115 USA.;Harvard Univ, Brigham & Womens Hosp, Sch Med, Div Aging, Boston, MA 02115 USA.
Visvanathan, Kala (författare)
Johns Hopkins Sidney Kimmel Comprehens Canc Ctr, Baltimore, MD USA.;Johns Hopkins Bloomberg Sch Publ Hlth, Baltimore, MD USA.
White, Emily (författare)
Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USA.
Wolk, Alicja (författare)
Karolinska Inst, Natl Inst Environm Med, Div Nutr Epidemiol, Stockholm, Sweden.
Zeleniuch-Jacquotte, Anne (författare)
NYU, Sch Med, Dept Populat Hlth, Div Epidemiol, New York, NY USA.;NYU, Sch Med, Inst Canc, New York, NY USA.
Hartge, Patricia (författare)
NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA.
visa färre...
NCI, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA.;Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA. (creator_code:org_t)
PUBLIC LIBRARY SCIENCE, 2014
2014
Engelska.
Ingår i: ; 11:7
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Background: The prevalence of class III obesity (body mass index [BMI]>= 40 kg/m(2)) has increased dramatically in several countries and currently affects 6% of adults in the US, with uncertain impact on the risks of illness and death. Using data from a large pooled study, we evaluated the risk of death, overall and due to a wide range of causes, and years of life expectancy lost associated with class III obesity. Methods and Findings: In a pooled analysis of 20 prospective studies from the United States, Sweden, and Australia, we estimated sex-and age-adjusted total and cause-specific mortality rates (deaths per 100,000 persons per year) and multivariable-adjusted hazard ratios for adults, aged 19-83 y at baseline, classified as obese class III (BMI 40.0-59.9 kg/m(2)) compared with those classified as normal weight (BMI 18.5-24.9 kg/m(2)). Participants reporting ever smoking cigarettes or a history of chronic disease (heart disease, cancer, stroke, or emphysema) on baseline questionnaires were excluded. Among 9,564 class III obesity participants, mortality rates were 856.0 in men and 663.0 in women during the study period (19762009). Among 304,011 normal-weight participants, rates were 346.7 and 280.5 in men and women, respectively. Deaths from heart disease contributed largely to the excess rates in the class III obesity group (rate differences = 238.9 and 132.8 in men and women, respectively), followed by deaths from cancer (rate differences = 36.7 and 62.3 in men and women, respectively) and diabetes (rate differences = 51.2 and 29.2 in men and women, respectively). Within the class III obesity range, multivariable-adjusted hazard ratios for total deaths and deaths due to heart disease, cancer, diabetes, nephritis/nephrotic syndrome/nephrosis, chronic lower respiratory disease, and influenza/pneumonia increased with increasing BMI. Compared with normal-weight BMI, a BMI of 40-44.9, 45-49.9, 50-54.9, and 55-59.9 kg/m(2) was associated with an estimated 6.5 (95% CI: 5.7-7.3), 8.9 (95% CI: 7.4-10.4), 9.8 (95% CI: 7.4-12.2), and 13.7 (95% CI: 10.5-16.9) y of life lost. A limitation was that BMI was mainly ascertained by self-report. Conclusions: Class III obesity is associated with substantially elevated rates of total mortality, with most of the excess deaths due to heart disease, cancer, and diabetes, and major reductions in life expectancy compared with normal weight.

Ämnesord

MEDICAL AND HEALTH SCIENCES  -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Hälsovetenskaper -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
MEDICIN OCH HÄLSOVETENSKAP  -- Hälsovetenskaper (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Health Sciences (hsv//eng)

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