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Preclinical atherosclerosis in adolescents with psychotic or bipolar disorders investigated with carotid high-frequency ultrasound.

Bohman, Hannes, 1965- (författare)
Uppsala universitet,Barn- och ungdomspsykiatri
Agartz, Ingrid (författare)
Department of Psychiatric Research, Diakonhjemmet Hospital, Oslo, Norway
Mansouri, Shiva (författare)
Department of Clinical Science and Education Södersjukhuset, Karolinska Institutet, Stockholm, Sweden
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Naessén, Tord (författare)
Uppsala universitet,Institutionen för kvinnors och barns hälsa
Lundberg, Mathias (författare)
Department of Clinical Science and Education Södersjukhuset, Karolinska Institutet, Stockholm, Sweden
Mansouri, S (författare)
Karolinska Institutet
Bohman, H (författare)
Karolinska Institutet
Agartz, I (författare)
Karolinska Institutet
Lundberg, M (författare)
Karolinska Institutet
Naessen, T (författare)
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 (creator_code:org_t)
2020
2020
Engelska.
Ingår i: Brain and Behavior. - 2162-3279 .- 2162-3279. ; 10:12
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • OBJECTIVE: Early-onset psychosis (EOP) and bipolar disorder (EOBP) (at <18 years of age), are associated with an increased future risk of cardiovascular disease (CVD) and premature death. Yet it is unknown whether the arteries show visible signs of atherosclerosis in EOP and EOBP. This study investigated whether having EOP or EOBP was associated with detectable signs of preclinical atherosclerosis.METHOD: By using 22 MHz high-frequency ultrasound, different layers of the arterial wall of the left common carotid artery (LCCA) were assessed in 77 individuals with EOP (n = 25), EOBP (n = 22), and in age-matched healthy controls (n = 30). Conventional CVD confounders were included in the analyses.RESULTS: Adolescents with EOP and EOBP, compared to controls, had a significantly thicker LCCA intima thickness (0.132 vs. 0.095 mm, p < .001) and intima/media ratio (0.24 vs. 0.17 p < .001). There was a nonsignificant intima difference between EOP and EOBP. Conventional CVD risk factors did not explain the association between EOP/EOBP and intima thickness. In the group of EOP/EOBP, there was a significant correlation between the dose of current antipsychotic medication and intima thickness; however, the correlation was attenuated to a nonsignificant level when adjusted for global function.CONCLUSIONS: Adolescents with EOP or EOBP had an increased LCCA intima thickness, interpreted as a sign of preclinical atherosclerosis. Global function of the disorders was the strongest determinant of intima thickness. The findings, if replicated, might have implications for long-term treatment of EOP and EOBP in order to reduce a future risk of CVD.

Ämnesord

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Kardiologi (hsv//swe)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine (hsv//eng)

Nyckelord

adolescents
atherosclerosis
bipolar disorder
psychosis
ultrasound

Publikations- och innehållstyp

ref (ämneskategori)
art (ämneskategori)

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