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Sökning: onr:"swepub:oai:DiVA.org:uu-431310" > Preclinical atheros...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004421naa a2200553 4500
001oai:DiVA.org:uu-431310
003SwePub
008210114s2020 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:144777045
024a urn:nbn:se:uu:diva-4313102 urn
024a https://doi.org/10.1002/brb3.18622 DOI
024a http://kipublications.ki.se/Default.aspx?queryparsed=id:1447770452 URI
040 a (SwePub)uud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
100a Bohman, Hannes,d 1965-u Uppsala universitet,Barn- och ungdomspsykiatri4 aut0 (Swepub:uu)hanbo757
2451 0a Preclinical atherosclerosis in adolescents with psychotic or bipolar disorders investigated with carotid high-frequency ultrasound.
264 1c 2020
338 a electronic2 rdacarrier
506 a gratis
506 a gratis
520 a OBJECTIVE: Early-onset psychosis (EOP) and bipolar disorder (EOBP) (at <18 years of age), are associated with an increased future risk of cardiovascular disease (CVD) and premature death. Yet it is unknown whether the arteries show visible signs of atherosclerosis in EOP and EOBP. This study investigated whether having EOP or EOBP was associated with detectable signs of preclinical atherosclerosis.METHOD: By using 22 MHz high-frequency ultrasound, different layers of the arterial wall of the left common carotid artery (LCCA) were assessed in 77 individuals with EOP (n = 25), EOBP (n = 22), and in age-matched healthy controls (n = 30). Conventional CVD confounders were included in the analyses.RESULTS: Adolescents with EOP and EOBP, compared to controls, had a significantly thicker LCCA intima thickness (0.132 vs. 0.095 mm, p < .001) and intima/media ratio (0.24 vs. 0.17 p < .001). There was a nonsignificant intima difference between EOP and EOBP. Conventional CVD risk factors did not explain the association between EOP/EOBP and intima thickness. In the group of EOP/EOBP, there was a significant correlation between the dose of current antipsychotic medication and intima thickness; however, the correlation was attenuated to a nonsignificant level when adjusted for global function.CONCLUSIONS: Adolescents with EOP or EOBP had an increased LCCA intima thickness, interpreted as a sign of preclinical atherosclerosis. Global function of the disorders was the strongest determinant of intima thickness. The findings, if replicated, might have implications for long-term treatment of EOP and EOBP in order to reduce a future risk of CVD.
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicin0 (SwePub)3022 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicine0 (SwePub)3022 hsv//eng
653 a adolescents
653 a atherosclerosis
653 a bipolar disorder
653 a psychosis
653 a ultrasound
700a Agartz, Ingridu Department of Psychiatric Research, Diakonhjemmet Hospital, Oslo, Norway4 aut
700a Mansouri, Shivau Department of Clinical Science and Education Södersjukhuset, Karolinska Institutet, Stockholm, Sweden4 aut
700a Naessén, Tordu Uppsala universitet,Institutionen för kvinnors och barns hälsa4 aut0 (Swepub:uu)tordnaes
700a Lundberg, Mathiasu Department of Clinical Science and Education Södersjukhuset, Karolinska Institutet, Stockholm, Sweden4 aut
700a Agartz, Iu Karolinska Institutet4 aut
700a Lundberg, Mu Karolinska Institutet4 aut
700a Bohman, Hu Karolinska Institutet4 aut
700a Naessen, T4 aut
700a Mansouri, Su Karolinska Institutet4 aut
710a Uppsala universitetb Barn- och ungdomspsykiatri4 org
773t Brain and Behaviorg 10:12q 10:12x 2162-3279x 2162-3279
856u https://doi.org/10.1002/brb3.1862
856u http://uu.diva-portal.org/smash/get/diva2:1517433/FULLTEXT01.pdf
8564 8u http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-431310x lärosäteslänky Till lärosätets (uu) databas
8564 8u https://doi.org/10.1002/brb3.1862
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:144777045

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