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In vivo evidence of...
In vivo evidence of a functional association between immune cells in blood and brain in healthy human subjects
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- Kanegawa, Naoki (författare)
- Karolinska Inst, Ctr Psychiat Res, Dept Clin Neurosci, Stockholm, Sweden.
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- Collste, Karin (författare)
- Karolinska Institutet
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- Forsberg, Anton (författare)
- Karolinska Institutet
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- Schain, Martin (författare)
- Karolinska Institutet
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- Arakawa, Ryosuke (författare)
- Karolinska Institutet
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- Jucaite, Aurelija (författare)
- Karolinska Institutet
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- Lekander, Mats (författare)
- Stockholms universitet,Stressforskningsinstitutet,Karolinska Institutet, Sweden,Karolinska Inst, Osher Ctr Integrat Med, Dept Clin Neurosci, Stockholm, Sweden.;Stockholm Univ, Stress Res Inst, S-10691 Stockholm, Sweden.
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- Hoglund, Caroline Olgart (författare)
- Karolinska Inst, Dept Physiol & Pharmacol, Stockholm, Sweden.;Karolinska Inst, Dept Med Solna, Stockholm, Sweden.;Karolinska Inst, CMM, Stockholm, Sweden.;Karolinska Univ, Hosp Solna, Stockholm, Sweden.
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- Kosek, Eva (författare)
- Karolinska Institutet
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- Lampa, Jon (författare)
- Karolinska Institutet
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- Halldin, Christer (författare)
- Karolinska Institutet
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- Farde, Lars (författare)
- Karolinska Institutet
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- Varrone, Andrea (författare)
- Karolinska Institutet
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- Cervenka, Simon (författare)
- Karolinska Institutet
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Karolinska Institutet Karolinska Inst, Ctr Psychiat Res, Dept Clin Neurosci, Stockholm, Sweden (creator_code:org_t)
- ACADEMIC PRESS INC ELSEVIER SCIENCE, 2016
- 2016
- Engelska.
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Ingår i: Brain, behavior, and immunity. - : ACADEMIC PRESS INC ELSEVIER SCIENCE. - 0889-1591 .- 1090-2139. ; 54, s. 149-157
- Relaterad länk:
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https://zenodo.org/r...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Microglia, the resident macrophages in the central nervous system, are thought to be maintained by a local self-renewal mechanism. Although preclinical and in vitro studies have suggested that the brain may contain immune cells also from peripheral origin, the functional association between immune cells in the periphery and brain at physiological conditions is poorly understood. We examined 32 healthy individuals using positron emission tomography (PET) and [C-11]PBR28, a radioligand for the 18-kDa translocator protein (TSPO) which is expressed both in brain microglia and blood immune cells. In 26 individuals, two measurements were performed with varying time intervals. In a subgroup of 19 individuals, of which 12 had repeat examinations, leukocyte numbers in blood was measured on each day of PET measurements. All individuals were genotyped for TSPO polymorphism and categorized as high, mixed, and low affinity binders. We assessed TSPO binding expressed as total distribution volume of [C-11]PBR28 in brain and in blood cells. TSPO binding in brain was strongly and positively correlated to binding in blood cells both at baseline and when analyzing change between two PET examinations. Furthermore, there was a significant correlation between change of leukocyte numbers and change in TSPO binding in brain, and a trend level correlation to change in TSPO binding in blood cells. These in vivo findings indicate an association between immunological cells in blood and brain via intact BBB, suggesting a functional interaction between these two compartments, such as interchange of peripherally derived cells or a common regulatory mechanism. Measurement of radioligand binding in blood cells may be a way to control for peripheral immune function in PET studies using TSPO as a marker of brain immune activation. (C) 2016 Elsevier Inc. All rights reserved.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Nyckelord
- PET
- [C-11]PBR28
- Translocator protein
- Microglia
- Blood immune cells
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Kanegawa, Naoki
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Collste, Karin
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Forsberg, Anton
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Schain, Martin
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Arakawa, Ryosuke
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Jucaite, Aurelij ...
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visa fler...
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Lekander, Mats
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Hoglund, Carolin ...
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Kosek, Eva
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Lampa, Jon
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Halldin, Christe ...
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Farde, Lars
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Varrone, Andrea
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Cervenka, Simon
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Neurologi
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinska och f ...
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och Neurovetenskaper
- Artiklar i publikationen
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Brain, behavior, ...
- Av lärosätet
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Uppsala universitet
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Stockholms universitet
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Karolinska Institutet