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Rapid and sustained relief from the symptoms of carcinoid syndrome : results from an open 6-month study of the 28-day prolonged-release formulation of lanreotide

Ruszniewski, Philippe (författare)
Ish-Shalom, Sofia (författare)
Wymenga, Machteld (författare)
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O'Toole, Dermot (författare)
Arnold, Rudolf (författare)
Tomassetti, Paola (författare)
Bax, Nigel (författare)
Caplin, Martyn (författare)
Eriksson, Barbro (författare)
Uppsala universitet,Institutionen för medicinska vetenskaper
Glaser, Benjamin (författare)
Ducreux, Michel (författare)
Lombard-Bohas, Catherine (författare)
de Herder, Wouter W. (författare)
Delle Fave, Gianfranco (författare)
Reed, Nick (författare)
Seitz, Jean Francois (författare)
Van Cutsem, Eric (författare)
Grossman, Ashley (författare)
Rougier, Philippe (författare)
Schmidt, Wolfgang (författare)
Wiedenmann, Bertram (författare)
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Ingår i: Neuroendocrinology. - 0028-3835 .- 1423-0194. ; 80:4, s. 244-251
  • Tidskriftsartikel (övrigt vetenskapligt)
Abstract Ämnesord
  • This 6-month, open, non-controlled, multicenter, dose-titration study evaluated the efficacy and safety of 28-day prolonged-release (PR) lanreotide in the treatment of carcinoid syndrome. Eligible patients had a carcinoid tumor with > or =3 stools/day and/or > or =1 moderate/severe flushing episodes/day. Six treatments of 28-day PR lanreotide were administered by deep subcutaneous injection. The dose for the first two injections was 90 mg. Subsequent doses could be titrated (60, 90, 120 mg) according to symptom response. Seventy-one patients were treated. Flushing decreased from a mean of 3.0 at baseline to 2.3 on day 1, and 2.0 on day 2, with a daily mean of 2.1 for the first week post-treatment (p < 0.05). Diarrhea decreased from a mean of 5.0 at baseline to 4.3 on day 1 (p < 0.05), and 4.5 on day 2, with a daily mean of 4.4 for the first week post-treatment (p < 0.001). Symptom frequency decreased further after the second and third injections, and reached a plateau after the fourth injection. By month 6, flushing and diarrhea had significantly decreased from baseline by a mean of 1.3 and 1.1 episodes/day, respectively (both p < or = 0.001); 65% of patients with flushing as the target symptom and 18% of diarrhea-target patients achieved > or =50% reduction from baseline. Median urinary 5-hydroxyindoleacetic acid and chromogranin A levels decreased by 24 and 38%, respectively. Treatment was well tolerated. 28-day PR lanreotide was effective in reducing the symptoms and biochemical markers associated with carcinoid syndrome.


Aged; 80 and over
Comparative Study
Delayed-Action Preparations/*therapeutic use
Dose-Response Relationship; Drug
Drug Administration Schedule
Drug Evaluation/methods
Flushing/drug therapy/physiopathology
Hydroxyindoleacetic Acid/urine
Malignant Carcinoid Syndrome/complications/*drug therapy/metabolism
Middle Aged
Peptides; Cyclic/blood/*therapeutic use
Quality of Life
Research Support; Non-U.S. Gov't
Somatostatin/*analogs & derivatives/blood/*therapeutic use
Time Factors
Treatment Outcome
Vipoma/drug therapy/physiopathology

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