SwePub
Sök i LIBRIS databas

  Utökad sökning

onr:"swepub:oai:DiVA.org:uu-77806"
 

Sökning: onr:"swepub:oai:DiVA.org:uu-77806" > Amphiphysin autoimm...

Amphiphysin autoimmunity : paraneoplastic accompaniments

Pittock, Sean J (författare)
Lucchinetti, Claudia F (författare)
Parisi, Jospeh E (författare)
visa fler...
Benarroch, Eduardo E (författare)
Mokri, Bahram (författare)
Stephan, Christina L (författare)
Kim, Kwang-Kuk (författare)
Kilimann, Manfred W (författare)
Uppsala universitet,Institutionen för neurovetenskap
Lennon, Vanda A (författare)
visa färre...
 (creator_code:org_t)
2005
2005
Engelska.
Ingår i: Annals of Neurology. - 0364-5134 .- 1531-8249. ; 58:1, s. 96-107
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Amphiphysin-IgG was identified in 71 patients among 120,000 evaluated serologically for paraneoplastic autoantibodies. Clinical information was available for 63 patients. Cancer was detected in 50 (mostly limited), proven histologically in 46, and was imaged intrathoracically in 4 patients (lung, small-cell [27] and non-small cell [1]), breast [16] and melanoma [2]). Neurological accompaniments included (decreasing frequency): neuropathy, encephalopathy, myelopathy, stiff-man phenomena, and cerebellar syndrome. In a case examined neuropathologically, parenchymal T-lymphocyte infiltration (predominantly CD8(+)) was prominent in lower brainstem, spinal cord, and dorsal root ganglion. Coexisting paraneoplastic autoantibodies, identified in 74% of patients, predicted a common neoplasm and indicated other neuronal autoantigen targets that plausibly explained several neurological manifestations; for example, P/Q-type Ca(2+)-channel antibody with Lambert-Eaton syndrome (n = 5), anti-neuronal nuclear antibody type 1 with sensory neuronopathy (n = 7), K(+)-channel antibody with limbic encephalitis (n = 1) or neuromyotonia (n = 1), and collapsin response-mediator protein-5-IgG with optic neuritis (n = 3). Patients with isolated amphiphysin-IgG (n = 19) were more likely to be women (with breast cancer, p < 0.05) and to have myelopathy or stiff-man phenomena (p < 0.01). Overall, a minority of women (39%) and men (12%) had stiff-man phenomena. Only 10% of women (some with lung carcinoma) and 4% of men fulfilled diagnostic criteria for stiff-man syndrome.

Nyckelord

MEDICINE
MEDICIN

Publikations- och innehållstyp

ref (ämneskategori)
art (ämneskategori)

Hitta via bibliotek

Till lärosätets databas

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy