SwePub
Sök i LIBRIS databas

  Utökad sökning

onr:"swepub:oai:DiVA.org:uu-97138"
 

Sökning: onr:"swepub:oai:DiVA.org:uu-97138" > Reliability of cycl...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003954naa a2200517 4500
001oai:DiVA.org:uu-97138
003SwePub
008080429s2006 | |||||||||||000 ||eng|
024a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-971382 URI
024a https://doi.org/10.1038/sj.bjc.66031472 DOI
040 a (SwePub)uu
041 a engb engb -1
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
100a Aaltonen, Kirsimari4 aut
2451 0a Reliability of cyclin A assessment on tissue microarrays in breast cancer compared to conventional histological slides
264 c 2006-05-02
264 1b Springer Science and Business Media LLC,c 2006
338 a print2 rdacarrier
520 a Cyclin A has in some studies been associated with poor breast cancer survival, although all studies have not confirmed this. Its prognostic significance in breast cancer needs evaluation in larger studies. Tissue microarray (TMA) technique allows a simultaneous analysis of large amount of tumours on a single microscopic slide. This makes a rapid screening of molecular markers in large amount of tumours possible. Because only a small tissue sample of each tumour is punched on an array, the question has arisen about the representativeness of TMA when studying markers that are expressed in only a small proportion of cells. For this reason, we wanted to compare cyclin A expression on TMA and on traditional large sections. Two breast cancer TMAs were constructed of 200 breast tumours diagnosed between 1997-1998. TMA slides and traditional large section slides of these 200 tumours were stained with cyclin A antibody and analysed by two independent readers. The reproducibility of the two readers' results was good or even very good, with kappa values 0.71-0.87. The agreement of TMA and large section results was good with kappa value 0.62-0.75. Cyclin A overexpression was significantly (P<0.001) associated with oestrogen receptor and progesterone receptor negativity and high grade both on TMA and large sections. Cyclin A overexpression was significantly associated with poor metastasis-free survival both on TMA and large sections. The relative risks for metastasis were similar on TMA and large sections. This study suggests that TMA technique could be useful to study histological correlations and prognostic significance of cyclin A on breast cancer on a large scale.
520 a 
653 a breast cancer
653 a cyclin A
653 a tissue microarray
653 a Biopsy/methods
653 a Breast Neoplasms/*pathology/radiotherapy
653 a Cyclin A/analysis/*genetics
653 a Female
653 a Humans
653 a Reproducibility of Results
653 a Tissue Array Analysis/*methods
653 a MEDICINE
653 a MEDICIN
700a Ahlin, Ceciliau Uppsala universitet,Institutionen för onkologi, radiologi och klinisk immunologi4 aut0 (Swepub:uu)cecah403
700a Amini, Rose-Marieu Uppsala universitet,Institutionen för genetik och patologi4 aut0 (Swepub:uu)roseamin
700a Salonen, Laura4 aut
700a Fjällskog, Marie Louiseu Uppsala universitet,Institutionen för onkologi, radiologi och klinisk immunologi4 aut0 (Swepub:uu)marifjal
700a Heikkilä, Pävi4 aut
700a Nevanlinna, Heli4 aut
700a Blomqvist, Carlu Uppsala universitet,Institutionen för onkologi, radiologi och klinisk immunologi4 aut0 (Swepub:uu)carlblom
710a Uppsala universitetb Institutionen för onkologi, radiologi och klinisk immunologi4 org
773t British Journal of Cancerd : Springer Science and Business Media LLCg 94:11, s. 1697-1702q 94:11<1697-1702x 0007-0920x 1532-1827
856u https://www.nature.com/articles/6603147.pdf
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-97138
8564 8u https://doi.org/10.1038/sj.bjc.6603147

Hitta via bibliotek

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy