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Sökning: onr:"swepub:oai:DiVA.org:uu-97138" > Reliability of cycl...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00004504naa a22005653a 4500
001oai:DiVA.org:uu-97138
003SwePub
008080901s2006 xx |||| |0|| 0|eng d
009oai:prod.swepub.kib.ki.se:112054827
024a 10.1038/sj.bjc.66031472 doi
024a 166707182 pmid
024a urn:nbn:se:uu:diva-971382 urn
040 a (SwePub)uud (SwePub)ki
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
100a Aaltonen, Kirsimari4 aut0 (SwePub:)
2451 0a Reliability of cyclin A assessment on tissue microarrays in breast cancer compared to conventional histological slides
500 a 8
500 a Published
5208 enga Cyclin A has in some studies been associated with poor breast cancer survival, although all studies have not confirmed this. Its prognostic significance in breast cancer needs evaluation in larger studies. Tissue microarray (TMA) technique allows a simultaneous analysis of large amount of tumours on a single microscopic slide. This makes a rapid screening of molecular markers in large amount of tumours possible. Because only a small tissue sample of each tumour is punched on an array, the question has arisen about the representativeness of TMA when studying markers that are expressed in only a small proportion of cells. For this reason, we wanted to compare cyclin A expression on TMA and on traditional large sections. Two breast cancer TMAs were constructed of 200 breast tumours diagnosed between 1997-1998. TMA slides and traditional large section slides of these 200 tumours were stained with cyclin A antibody and analysed by two independent readers. The reproducibility of the two readers' results was good or even very good, with kappa values 0.71-0.87. The agreement of TMA and large section results was good with kappa value 0.62-0.75. Cyclin A overexpression was significantly (P<0.001) associated with oestrogen receptor and progesterone receptor negativity and high grade both on TMA and large sections. Cyclin A overexpression was significantly associated with poor metastasis-free survival both on TMA and large sections. The relative risks for metastasis were similar on TMA and large sections. This study suggests that TMA technique could be useful to study histological correlations and prognostic significance of cyclin A on breast cancer on a large scale.
650 7a MEDICIN OCH HÄLSOVETENSKAP2 hsv//swe0 (SwePub)3
650 7a MEDICAL AND HEALTH SCIENCES2 hsv//eng0 (SwePub)3
653 a MEDICINE
653 a MEDICIN
653 a breast cancer
653 a cyclin A
653 a tissue microarray
653 a Biopsy/methods
653 a Breast Neoplasms/*pathology/radiotherapy
653 a Cyclin A/analysis/*genetics
653 a Female
653 a Humans
653 a Reproducibility of Results
653 a Tissue Array Analysis/*methods
700a Ahlin, Cecilia,u Uppsala universitet, Institutionen för onkologi, radiologi och klinisk immunologi4 aut0 (SwePub:uu)cecah403
700a Amini, Rose-Marie,u Uppsala universitet, Institutionen för genetik och patologi4 aut0 (SwePub:uu)roseamin
700a Salonen, Laura4 aut0 (SwePub:)
700a Fjällskog, Marie Louise,u Uppsala universitet, Institutionen för onkologi, radiologi och klinisk immunologi4 aut0 (SwePub:uu)marifjal
700a Heikkilä, Pävi4 aut0 (SwePub:)
700a Nevanlinna, Heli4 aut0 (SwePub:)
700a Blomqvist, Carl,u Uppsala universitet, Institutionen för onkologi, radiologi och klinisk immunologi4 aut0 (SwePub:uu)carlblom
700a Fjallskog, ML4 aut0 (SwePub:ki)
700a Heikkila, P4 aut0 (SwePub:ki)
710a Uppsala universitet.b Medicinska och farmaceutiska vetenskapsområdet.b Medicinska fakulteten.b Institutionen för onkologi, radiologi och klinisk immunologi.4 org0 (SwePub:uu)1396
710a Uppsala universitet.b Medicinska och farmaceutiska vetenskapsområdet.b Medicinska fakulteten.b Institutionen för genetik och patologi.4 org0 (SwePub:uu)1343
773t British Journal of Cancerx 0007-0920x 1532-1827g 94:11, s. 1697-1702q 94:11<1697-1702
8564 8u http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-97138y Till lärosätets (uu) databasx lärosäteslänk
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:112054827y Till lärosätets (ki) databasx lärosäteslänk
8564 8u http://dx.doi.org/10.1038/sj.bjc.6603147

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