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Sökning: onr:"swepub:oai:DiVA.org:uu-97138" > Reliability of cycl...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003954naa a2200517 4500
001oai:DiVA.org:uu-97138
003SwePub
008080429s2006 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-971382 URI
0247 a https://doi.org/10.1038/sj.bjc.66031472 DOI
040 a (SwePub)uu
041 a engb engb -1
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Aaltonen, Kirsimari4 aut
2451 0a Reliability of cyclin A assessment on tissue microarrays in breast cancer compared to conventional histological slides
264 c 2006-05-02
264 1b Springer Science and Business Media LLC,c 2006
338 a print2 rdacarrier
520 a Cyclin A has in some studies been associated with poor breast cancer survival, although all studies have not confirmed this. Its prognostic significance in breast cancer needs evaluation in larger studies. Tissue microarray (TMA) technique allows a simultaneous analysis of large amount of tumours on a single microscopic slide. This makes a rapid screening of molecular markers in large amount of tumours possible. Because only a small tissue sample of each tumour is punched on an array, the question has arisen about the representativeness of TMA when studying markers that are expressed in only a small proportion of cells. For this reason, we wanted to compare cyclin A expression on TMA and on traditional large sections. Two breast cancer TMAs were constructed of 200 breast tumours diagnosed between 1997-1998. TMA slides and traditional large section slides of these 200 tumours were stained with cyclin A antibody and analysed by two independent readers. The reproducibility of the two readers' results was good or even very good, with kappa values 0.71-0.87. The agreement of TMA and large section results was good with kappa value 0.62-0.75. Cyclin A overexpression was significantly (P<0.001) associated with oestrogen receptor and progesterone receptor negativity and high grade both on TMA and large sections. Cyclin A overexpression was significantly associated with poor metastasis-free survival both on TMA and large sections. The relative risks for metastasis were similar on TMA and large sections. This study suggests that TMA technique could be useful to study histological correlations and prognostic significance of cyclin A on breast cancer on a large scale.
520 a 
653 a breast cancer
653 a cyclin A
653 a tissue microarray
653 a Biopsy/methods
653 a Breast Neoplasms/*pathology/radiotherapy
653 a Cyclin A/analysis/*genetics
653 a Female
653 a Humans
653 a Reproducibility of Results
653 a Tissue Array Analysis/*methods
653 a MEDICINE
653 a MEDICIN
7001 a Ahlin, Ceciliau Uppsala universitet,Institutionen för onkologi, radiologi och klinisk immunologi4 aut0 (Swepub:uu)cecah403
7001 a Amini, Rose-Marieu Uppsala universitet,Institutionen för genetik och patologi4 aut0 (Swepub:uu)roseamin
7001 a Salonen, Laura4 aut
7001 a Fjällskog, Marie Louiseu Uppsala universitet,Institutionen för onkologi, radiologi och klinisk immunologi4 aut0 (Swepub:uu)marifjal
7001 a Heikkilä, Pävi4 aut
7001 a Nevanlinna, Heli4 aut
7001 a Blomqvist, Carlu Uppsala universitet,Institutionen för onkologi, radiologi och klinisk immunologi4 aut0 (Swepub:uu)carlblom
7102 a Uppsala universitetb Institutionen för onkologi, radiologi och klinisk immunologi4 org
7730 t British Journal of Cancerd : Springer Science and Business Media LLCg 94:11, s. 1697-1702q 94:11<1697-1702x 0007-0920x 1532-1827
8564 u https://www.nature.com/articles/6603147.pdf
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-97138
8564 8u https://doi.org/10.1038/sj.bjc.6603147

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