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Alcohol intake as a risk factor for fracture.

Kanis, John A (författare)
Johansson, Helena, 1981 (författare)
University of Gothenburg,Göteborgs universitet (GU),Gothenburg University,Göteborgs universitet,Institutionen för samhällsmedicin, Avdelningen för geriatrik,Institute of Community Medicine, Dept of Geriatric Medicine
Johnell, Olof (författare)
Lund University,Lunds universitet,Ortopedi - klinisk och molekylär osteoporosforskning,Forskargrupper vid Lunds universitet,Orthopedics - Clinical and Molecular Osteoporosis Research,Lund University Research Groups
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Odén, Anders, 1942 (författare)
University of Gothenburg,Chalmers University of Technology,Göteborgs universitet (GU),Chalmers tekniska högskola,Gothenburg University,Göteborgs universitet,Institutionen för matematiska vetenskaper, matematisk statistik,Department of Mathematical Sciences, Mathematical Statistics
De Laet, Chris (författare)
Eisman, John A (författare)
Pols, Huibert (författare)
Tenenhouse, Alan (författare)
De Laet, C (författare)
Eisman, JA (författare)
Pols, H (författare)
Kanis, JA (författare)
Tenenhouse, A (författare)
Johansson, H (författare)
Oden, A (författare)
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Springer, 2005
2005
Engelska.
Ingår i: Osteoporosis international. - : Springer. - 0937-941X .- 1433-2965. ; 16:7, s. 737-42
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • High intakes of alcohol have adverse effects on skeletal health, but evidence for the effects of moderate consumption are less secure. The aim of this study was to quantify this risk on an international basis and explore the relationship of this risk with age, sex, and bone mineral density (BMD). We studied 5,939 men and 11,032 women from three prospectively studied cohorts comprising CaMos, DOES, and the Rotterdam Study. Cohorts were followed for a total of 75,433 person-years. The effect of reported alcohol intake on the risk of any fracture, any osteoporotic fracture, and hip fracture alone was examined using a Poisson model for each sex from each cohort. Covariates examined included age and BMD. The results of the different studies were merged using weighted beta-coefficients. Alcohol intake was associated with a significant increase in osteoporotic and hip fracture risk, but the effect was nonlinear. No significant increase in risk was observed at intakes of 2 units or less daily. Above this threshold, alcohol intake was associated with an increased risk of any fracture (risk ratio [RR] = 1.23; 95% CI, 1.06-1.43), any osteoporotic fracture (RR = 1.38; 95% CI, 1.16-1.65), or hip fracture (RR = 1.68; 95% CI, 1.19-2.36). There was no significant interaction with age, BMD, or time since baseline assessment. Risk ratios were moderately but not significantly higher in men than in women, and there was no evidence for a different threshold for effect by gender. We conclude that reported intake of alcohol confers a risk of some importance beyond that explained by BMD. The validation of this risk factor on an international basis permits its use in case-finding strategies.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper (hsv//swe)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine (hsv//eng)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Ortopedi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Orthopedics (hsv//eng)

Nyckelord

Adult
Age Factors
Alcohol Drinking
adverse effects
Bone Density
Female
Follow-Up Studies
Fractures
Bone
etiology
physiopathology
Hip Fractures
etiology
physiopathology
Humans
Male
Middle Aged
Osteoporosis
etiology
physiopathology
Prospective Studies
Risk Assessment
Risk Factors
Sex Factors
risk
factors
osteoporotic fracture
meta-analysis
hip fracture
alcohol
Bone Density

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