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Impact of growth ho...
Impact of growth hormone therapy on quality of life in adults with turner syndrome.
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- Amundson, Emily (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine
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- Wide Boman, Ulla, 1964 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine
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- Barrenäs, Marie-Louise, 1952 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institute of Clinical Sciences, Department of Pediatrics
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- Bryman, Inger (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för obstetrik och gynekologi,Institute of Clinical Sciences, Department of Obstetrics and Gynecology
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- Landin-Wilhelmsen, Kerstin, 1952 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine
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(creator_code:org_t)
- The Endocrine Society, 2010
- 2010
- Engelska.
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Ingår i: The Journal of clinical endocrinology and metabolism. - : The Endocrine Society. - 1945-7197 .- 0021-972X. ; 95:3, s. 1355-9
- Relaterad länk:
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https://academic.oup...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Context: GH and/or oxandrolone are used to promote growth in Turner syndrome (TS). Objective: The aim of this study was to compare quality of life (QoL) in TS women with controls and determine the impact of growth promoting therapy on QoL in TS women. Design: This was a cross-sectional, case-control study. Setting: The study was conducted at an outpatient clinic at Sahlgrenska University Hospital, Göteborg, Sweden. Patients: Patients included 111 TS women (age range 18-59 yr) and 111 randomly selected, age-matched women (25-54 yr) from the World Health Organization Monitoring Trends and Determinants for Cardiovascular Disease project (Göteborg, Sweden) served as controls. Main Outcome Measures: QoL was estimated by the Psychological General Well-Being scale (anxiety, depressed mood, positive well-being, self-control, general health and vitality) and the Nottingham Health Profile (physical mobility, pain, sleep, energy, social isolation, and emotional reactions). Results: TS women reported more social isolation than controls (P < 0.001). After age adjustment, significantly less pain (<0.05) was reported attributable to GH treatment within TS. No significant difference in any other subscales used could be shown. In TS, QoL was negatively affected by higher current age and age at diagnosis and positively affected by better body balance, fine motor function, and higher bone mineral density. Conclusions: Social isolation was more commonly reported in the whole TS cohort than in the population. Except for less pain, no significant impact on QoL attributable to GH treatment could be found, despite the mean +5.1 cm final height.
Nyckelord
- Adolescent
- Adult
- Age Factors
- Anthropometry
- Body Height
- drug effects
- Bone Density
- Case-Control Studies
- Chi-Square Distribution
- Cross-Sectional Studies
- Female
- Health Status
- Human Growth Hormone
- therapeutic use
- Humans
- Middle Aged
- Motor Skills
- Odds Ratio
- Personality Inventory
- Quality of Life
- psychology
- Questionnaires
- Recombinant Proteins
- therapeutic use
- Social Isolation
- Sweden
- Turner Syndrome
- psychology
- therapy
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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