Progression from mild to pronounced MCI is not associated with cerebrospinal fluid biomarker deviations.

• Background/Aim: Detection of cerebrospinal fluid (CSF) biomarker deviations improve prediction of progression from mild cognitive impairment (MCI) to dementia. However, it is not settled whether the same pattern exists in patients progressing from very mild to more pronounced MCI. Given that neurodegenerative processes occur very early in the disease course, we also expected to find biomarker deviations in these patients. Methods: A total of 246 memory clinic patients with non-progressive (n = 161), progressive (n = 19), or converting (n = 66) MCI, 67 with stable dementia, and 80 controls were followed for 24 months. At baseline, CSF total tau (T-tau), β-amyloid 1–42 (Aβ42) and the light subunit of neurofilament protein (NFL) were determined. Results: Patients with converting MCI and stable dementia had lower CSF Aβ42 concentrations and higher T-tau concentrations and NFL in comparison with controls and non-progressive/progressive MCI (p < 0.0005). No differences were found between progressive and non-progressive MCI. Conclusion: As expected, biomarker deviations predicted progression from MCI to dementia. Contrary to our hypothesis, progression from very mild MCI to more pronounced MCI was not reflected by biomarker deviations. The results suggest that the measured biomarkers are not early disease markers, or alternatively Alzheimer or vascular pathology is not the underlying cause in this patient group.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine (hsv//eng)

Nyckelord

Aged

Alzheimer Disease

cerebrospinal fluid

psychology

Amyloid beta-Peptides

cerebrospinal fluid

Apolipoproteins E

blood

Biological Markers

cerebrospinal fluid

Dementia

cerebrospinal fluid

psychology

Disease Progression

Educational Status

Electroencephalography

Female

Humans

Magnetic Resonance Imaging

Male

Middle Aged

Mild Cognitive Impairment

cerebrospinal fluid

psychology

Neurofilament Proteins

cerebrospinal fluid

Neuropsychological Tests

Peptide Fragments

cerebrospinal fluid

Tomography

Emission-Computed

Single-Photon

tau Proteins

cerebrospinal fluid

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