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Disconnectivity of the cortical ocular motor control network in autism spectrum disorders

Kenet, T. (författare)
Orekhova, Elena V, 1967- (författare)
Bharadwaj, H. (författare)
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Shetty, N. R. (författare)
Israeli, E. (författare)
Lee, A. K. C. (författare)
Agam, Y. (författare)
Elam, Mikael, 1956- (författare)
Göteborgs universitet, Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap och rehabilitering, Gothenburg University, Institute of Neuroscience and Physiology, Department of Clinical Neuroscience and Rehabilitation
Joseph, R. M. (författare)
Hamalainen, M. S. (författare)
Manoach, D. S. (författare)
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Göteborgs universitet Sahlgrenska akademin. Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap och rehabilitering. 
2012
Engelska.
Ingår i: Neuroimage. - 1053-8119. ; 61:4, s. 1226-1234
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • Response inhibition, or the suppression of prepotent but contextually inappropriate behaviors, is essential to adaptive, flexible responding. Individuals with autism spectrum disorders (ASD) consistently show deficient response inhibition during antisaccades. In our prior functional MRI study, impaired antisaccade performance was accompanied by reduced functional connectivity between the frontal eye field (FEF) and dorsal anterior cingulate cortex (dACC), regions critical to volitional ocular motor control. Here we employed magnetoencephalography (MEG) to examine the spectral characteristics of this reduced connectivity. We focused on coherence between FEF and dACC during the preparatory period of antisaccade and prosaccade trials, which occurs after the presentation of the task cue and before the imperative stimulus. We found significant group differences in alpha band mediated coherence. Specifically, neurotypical participants showed significant alpha band coherence between the right inferior FEF and right dACC and between the left superior FEF and bilateral dACC across antisaccade, prosaccade, and fixation conditions. Relative to the neurotypical group, ASD participants showed reduced coherence between these regions in all three conditions. Moreover, while neurotypical participants showed increased coherence between the right inferior FEF and the right dACC in preparation for an antisaccade compared to a prosaccade or fixation, ASD participants failed to show a similar increase in preparation for the more demanding antisaccade. These findings demonstrate reduced long-range functional connectivity in ASD, specifically in the alpha band. The failure in the ASD group to increase alpha band coherence with increasing task demand may reflect deficient top-down recruitment of additional neural resources in preparation to perform a difficult task. (C) 2012 Elsevier Inc. All rights reserved.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska grundvetenskaper -- Neurovetenskaper (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Neurosciences (hsv//eng)

Nyckelord

Autism
ASD
Connectivity
Alpha synchrony
MEG
frontal eye-field
anterior cingulate cortex
visually guided saccades
high-functioning autism
positron-emission-tomography
voxel-based
morphometry
space separation method
surface-based analysis
event-related fmri
preparatory set

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