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UVB-induced melanocyte proliferation and 5-S-cysteinyldopa excretion in dysplastic nevus syndrome.

Stierner, Ulrika, 1952- (författare)
Göteborgs universitet, Medicinska institutionen, Gothenburg University, Department medicine
Augustsson, A, (författare)
Göteborgs universitet, Medicinska institutionen, Gothenburg University, Department medicine
Rosdahl, Inger, 1943- (författare)
Göteborgs universitet, Medicinska institutionen, Gothenburg University, Department medicine
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Kågedal, B (författare)
Suurküla, Madis (författare)
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Göteborgs universitet Sahlgrenska akademin. Medicinska institutionen. 
1988
Engelska.
Ingår i: Photo-dermatology. - 0108-9684. ; 5:5, s. 218-23
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • This is the first in vivo study of the effects of UV on the epidermal melanocytes in dysplastic nevus syndrome (DNS). Eleven DNS patients and 22 healthy subjects were given total body UVB irradiation 8 times during 17 days and the melanocyte population was estimated in biopsies from shielded and irradiated skin. There was a doubling of the melanocyte counts in irradiated skin and a less pronounced but significant increase in the shielded skin area. The urinary excretion of 5-S-cysteinyldopa (5-S-CD) was measured before, during and after the irradiation period. The 5-S-CD excretion reached a maximum after 2 weeks of irradiation and returned towards the basal value after the irradiation period. We were not able to document any abnormal melanocytic UV response in DNS patients before, during or after the irradiation.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

Nyckelord

Adult
Aged
Cell Count
Cell Division
radiation effects
Chromatography
High Pressure Liquid
Cysteinyldopa
analysis
urine
Dihydroxyphenylalanine
analogs & derivatives
Dysplastic Nevus Syndrome
pathology
urine
Female
Humans
Male
Melanocytes
pathology
radiation effects
Middle Aged
Skin
pathology
Ultraviolet Rays

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