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Sökning: onr:"swepub:oai:gup.ub.gu.se/165228" > P2RX7:

  • Backlund, Lena (författare)

P2RX7: Expression Responds to Sleep Deprivation and Associates with Rapid Cycling in Bipolar Disorder Type 1

  • E-artikel/E-kapitelEngelska2012


  • LIBRIS-ID:oai:gup.ub.gu.se/165228
  • 000308213600013isi
  • 84865522885scopus
  • 22952630pmid
  • 10.1371/journal.pone.0043057doi

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  • Ämneskategori:art swepub-publicationtype
  • Ämneskategori:ref swepub-contenttype


  • Published
  • 11
  • not verified at registration
  • Context: Rapid cycling is a severe form of bipolar disorder with an increased rate of episodes that is particularly treatment-responsive to chronotherapy and stable sleep-wake cycles. We hypothesized that the P2RX7 gene would be affected by sleep deprivation and be implicated in rapid cycling. Objectives: To assess whether P2RX7 expression is affected by total sleep deprivation and if variation in P2RX7 is associated with rapid cycling in bipolar patients. Design: Gene expression analysis in peripheral blood mononuclear cells (PBMCs) from healthy volunteers and case-case and case-control SNP/haplotype association analyses in patients. Participants: Healthy volunteers at the sleep research center, University of California, Irvine Medical Center (UCIMC), USA (n = 8) and Swedish outpatients recruited from specialized psychiatric clinics for bipolar disorder, diagnosed with bipolar disorder type 1 (n = 569; rapid cycling: n = 121) and anonymous blood donor controls (n = 1,044). Results: P2RX7 RNA levels were significantly increased during sleep deprivation in PBMCs from healthy volunteers (p = 2.3*10(-9)). The P2RX7 rs2230912_A allele was more common (OR = 2.2, p = 0.002) and the ACGTTT haplotype in P2RX7 (rs1718119 to rs1621388) containing the protective rs2230912_G allele (OR = 0.45-0.49, p = 0.003-0.005) was less common, among rapid cycling cases compared to non-rapid cycling bipolar patients and blood donor controls. Conclusions: Sleep deprivation increased P2RX7 expression in healthy persons and the putatively low-activity P2RX7 rs2230912 allele A variant was associated with rapid cycling in bipolar disorder. This supports earlier findings of P2RX7 associations to affective disorder and is in agreement with that particularly rapid cycling patients have a more vulnerable diurnal system.

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Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Lavebratt, Catharina(SwePub:) (författare)
  • Frisen, Louise(SwePub:) (författare)
  • Nikamo, Pernilla(SwePub:) (författare)
  • Sudic, Dzana Hukic(SwePub:) (författare)
  • Träskman Bendz, Lil,Lunds universitet, Lund University, Medicinska fakulteten, Faculty of Medicine, Institutionen för kliniska vetenskaper, Lund, Department of Clinical Sciences, Lund, Sektion IV, Section IV, Psykiatri, Lund, Psychiatry (Lund)(SwePub:) (författare)
  • Landen, Mikael(SwePub:) (författare)
  • Edman, Gunnar(SwePub:) (författare)
  • Vawter, Marquis P.(SwePub:) (författare)
  • Osby, Urban(SwePub:) (författare)
  • Schalling, Martin(SwePub:) (författare)
  • Traskman-Bendz, L.(SwePub:gu.se)185809 (författare)
  • Landén, Mikael,1966-,Göteborgs universitet, Institutionen för neurovetenskap och fysiologi, Gothenburg University, Institute of Neuroscience and Physiology(SwePub:gu.se)xlandt (författare)
  • Landen, M,Karolinska Institutet(SwePub:ki)95afb9d754c77eb79e82fc241f665426 (författare)
  • Göteborgs universitet.Sahlgrenska akademin.Institutionen för neurovetenskap och fysiologi.(SwePub:gu.se)1384
  • Gothenburg University.Sahlgrenska Academy.Institute of Neuroscience and Physiology.(SwePub:gu.se)1384

Sammanhörande titlar

  • Ingår i:Plos One1932-62037:8


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