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LIBRIS Formathandbok  (Information om MARC21)
00004412naa a22005413a 4500
008080901s2012 xx |||| |0|| 0|eng d
024a 0003095561001152 isi
024a 10.1371/journal.pone.00459942 doi
024a 230499162 pmid
040 a (SwePub)gud (SwePub)ki
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
100a Johansson, V.4 aut0 (SwePub:gu.se)187531
2451 0a Microscopic Particles in Two Fractions of Fresh Cerebrospinal Fluid in Twins with Schizophrenia or Bipolar Disorder and in Healthy Controls
500 a not verified at registration
500 a Published
500 a 8
520a Background: Using scanning electron microscopy, microscopic structures have been identified in fresh cerebrospinal fluid (CSF) in patients with schizophrenia and bipolar disorder, but only rarely in control subjects. However, it has not been determined whether these microscopic particles represent state or trait markers, i.e. if their presence is related to clinical manifestations of the disease or if they also can be found in as yet asymptomatic individuals with a genetic liability. This question can be addressed by studying twins discordant or concordant for schizophrenia or bipolar disorder. Methodology/Principal Findings: We investigated microscopic structures in CSF in 102 individuals: 21 monozygotic and 16 dizygotic twins affected or not affected with schizophrenia, schizoaffective disorder or bipolar disorder and in 65 healthy singleton controls. A first and a second fraction of CSF was freshly applied on filters and examined by scanning electron microscopy technique. Spherical particles with lipid appearance averaging between 0.1 to 8.0 mu m in diameter were detected in the center of the filter as well as located in the margins of larger aggregates binding in a viscous state. Structures were found in 12 of 17 probands, 5 of 12 healthy co-twins and 3 of 73 healthy controls. Thus, a positive microscopic finding significantly increased the likelihood of belonging to the proband group (OR = 48, 95% CL: 8.2-550, p<0.0001) and the co-twin-group (OR = 16, 95% CL: 2.0-218, p = 0.006). Age, sex, history of alcohol abuse or anxiety syndrome, somatic disorder and markers of acute inflammatory activity did not account for group differences; nor did exposure to psychotropic medication. Conclusion: Presence of microscopic particles in CSF may possibly reflect trait dependent genetic or environmental vulnerability in patients with schizophrenia, schizoaffective disorder or bipolar disorder.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicin2 hsv//swe0 (SwePub)302
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicine2 hsv//eng0 (SwePub)302
653 a micrometer-sized particles
653 a central-nervous-system
653 a rating-scale
653 a interview
653 a barrier
653 a csf
653 a pathophysiology
653 a identification
653 a childhood
653 a rationale
700a Nybom, R.4 aut0 (SwePub:gu.se)187532
700a Wetterberg, L.4 aut0 (SwePub:gu.se)187533
700a Hultman, C. M.4 aut0 (SwePub:gu.se)147103
700a Cannon, T. D.4 aut0 (SwePub:gu.se)187534
700a Johansson, A. G. M.4 aut0 (SwePub:gu.se)187535
700a Ekman, C. J.4 aut0 (SwePub:gu.se)187536
700a Landén, Mikael,d 1966-,u Göteborgs universitet, Institutionen för neurovetenskap och fysiologi, Gothenburg University, Institute of Neuroscience and Physiology4 aut0 (SwePub:gu.se)xlandt
700a Landen, M,u Karolinska Institutet4 aut0 (SwePub:ki)95afb9d754c77eb79e82fc241f665426
7108 swea Göteborgs universitet.b Sahlgrenska akademin.b Institutionen för neurovetenskap och fysiologi.0 (SwePub:gu.se)1384
7108 enga Gothenburg University.b Sahlgrenska Academy.b Institute of Neuroscience and Physiology.0 (SwePub:gu.se)1384
773t Plos Onex 1932-6203g 7:9q 7:9
8564 8u https://gup.ub.gu.se/publication/166564y Till lärosätets (gu) databasx lärosäteslänk
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:125482891y Till lärosätets (ki) databasx lärosäteslänk
8564 8u http://dx.doi.org/10.1371/journal.pone.0045994

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