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Wood smoke particle...
Wood smoke particles from different combustion phases induce similar pro-inflammatory effects in a co-culture of monocyte and pneumocyte cell lines.
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Bølling, Anette Kocbach (författare)
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Totlandsdal, Annike Irene (författare)
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- Sällsten, Gerd, 1952 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa,Institute of Medicine, School of Public Health and Community Medicine
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Braun, Artur (författare)
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- Westerholm, Roger (författare)
- Stockholms universitet,Institutionen för analytisk kemi
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- Bergvall, Christoffer (författare)
- Stockholms universitet,Institutionen för analytisk kemi
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- Boman, Johan, 1955 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för kemi och molekylärbiologi,Department of Chemistry and Molecular Biology
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Dahlman, Hans Jørgen (författare)
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- Sehlstedt, Maria (författare)
- Umeå universitet,Lungmedicin
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Cassee, Flemming (författare)
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- Sandström, Thomas (författare)
- Umeå universitet,Lungmedicin
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Schwarze, Per E (författare)
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Herseth, Jan Inge (författare)
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(creator_code:org_t)
- Springer Science and Business Media LLC, 2012
- 2012
- Engelska.
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Ingår i: Particle and fibre toxicology. - : Springer Science and Business Media LLC. - 1743-8977. ; 9:1
- Relaterad länk:
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https://gup.ub.gu.se... (primary) (free)
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https://particleandf...
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https://doi.org/10.1...
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https://gup.ub.gu.se...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- ABSTRACT: BACKGROUND: Exposure to particulate matter (PM) has been linked to several adverse cardiopulmonary effects, probably via biological mechanisms involving inflammation. The pro-inflammatory potential of PM depends on the particles' physical and chemical characteristics, which again depend on the emitting source. Wood combustion is a major source of ambient air pollution in northern countries during the winter season. The overall aim of this study was therefore to investigate the cellular responses to wood smoke particles (WSPs) collected from different phases of the combustion cycle, and from combustion at different temperatures. RESULTS: WSPs from different phases of the combustion cycle induced very similar effects on pro-inflammatory mediator release, cytotoxicity and cell number, whereas WSPs from medium-temperature combustion were more cytotoxic than WSPs from high-temperature incomplete combustion. Furthermore, comparisons of effects induced by native WSPs with the corresponding organic extracts and washed particles revealed that the organic fraction was the most important determinant for the WSP-induced effects. However, the responses induced by the organic fraction could generally not be linked to the content of the measured polycyclic aromatic hydrocarbons (PAHs), suggesting that also other organic compounds were involved. CONCLUSION: The toxicity of WSPs seems to a large extent to be determined by stove type and combustion conditions, rather than the phase of the combustion cycle. Notably, this toxicity seems to strongly depend on the organic fraction, and it is probably associated with organic components other than the commonly measured unsubstituted PAHs.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
- NATURVETENSKAP -- Kemi -- Analytisk kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Analytical Chemistry (hsv//eng)
Nyckelord
- Particulate matter
- Inflammation
- Wood smoke
- Combustion phase
- Combustion temperature
- Organic fraction
- Particulate matter
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Bølling, Anette ...
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Totlandsdal, Ann ...
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Sällsten, Gerd, ...
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Braun, Artur
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Westerholm, Roge ...
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Bergvall, Christ ...
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visa fler...
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Boman, Johan, 19 ...
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Dahlman, Hans Jø ...
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Sehlstedt, Maria
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Cassee, Flemming
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Sandström, Thoma ...
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Schwarze, Per E
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Herseth, Jan Ing ...
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visa färre...
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NATURVETENSKAP
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och Analytisk kemi
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Particle and fib ...
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Göteborgs universitet
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Umeå universitet
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Stockholms universitet